Ramhorst, R.; Calo, G.; Paparini, D.; Vota, D.; Hauk, V.; Gallino, L.; Merech, F.; Grasso, E.; Leirós, C.P. "Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide" (2019) Annals of the New York Academy of Sciences. 1437(1):15-21
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A network of cell–cell communications through contact and soluble factors supports the maternal–placental interaction and provides a suitable environment for fetal growth. Trophoblast cells take center stage at these loops: they interact with maternal leukocytes to sustain the varying demands of gestation, and they synthesize hormones, cytokines among other factors that contribute to the maintenance of immune homeostasis. Here, we discuss vasoactive intestinal peptide (VIP) and its potential as a regulatory neuropeptide in pregnancy. VIP is synthesized by trophoblast cells; it regulates trophoblast cell function and interaction with the major immune cell populations present in the pregnant uterus. VIP activity produces an anti-inflammatory microenvironment by modulating the functional profile of monocytes, macrophages, and regulatory T cells. Trophoblast VIP inhibits neutrophil extracellular trap formation and accelerates neutrophil apoptosis, enabling their silent clearance by phagocytic cells. The effects of VIP on the trophoblast–immune interaction are consistent with its regulatory role throughout pregnancy for immune homeostasis maintenance. These observations may provide new clues for pharmacological targeting of pregnancy complications associated with exacerbated inflammation. © 2018 New York Academy of Sciences.


Documento: Artículo
Título:Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide
Autor:Ramhorst, R.; Calo, G.; Paparini, D.; Vota, D.; Hauk, V.; Gallino, L.; Merech, F.; Grasso, E.; Leirós, C.P.
Filiación:Laboratory of Immunopharmacology, Department of Biological Chemistry, School of Sciences, University of Buenos Aires, Buenos Aires, Argentina
IQUIBICEN-CONICET, Ciudad Universitaria, Buenos Aires, Argentina
Palabras clave:Immune homeostasis; Pregnancy; Trophoblast cell lines; Vasoactive intestinal polypeptide; vasoactive intestinal polypeptide; apoptosis; cell population; disease control; extracellular trap; homeostasis; human; inflammation; macrophage; monocyte; neutrophil; phagocyte; pregnancy; pregnancy complication; regulatory T lymphocyte; Review; trophoblast
Página de inicio:15
Página de fin:21
Título revista:Annals of the New York Academy of Sciences
Título revista abreviado:Ann. New York Acad. Sci.
CAS:vasoactive intestinal polypeptide, 37221-79-7


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---------- APA ----------
Ramhorst, R., Calo, G., Paparini, D., Vota, D., Hauk, V., Gallino, L., Merech, F.,..., Leirós, C.P. (2019) . Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide. Annals of the New York Academy of Sciences, 1437(1), 15-21.
---------- CHICAGO ----------
Ramhorst, R., Calo, G., Paparini, D., Vota, D., Hauk, V., Gallino, L., et al. "Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide" . Annals of the New York Academy of Sciences 1437, no. 1 (2019) : 15-21.
---------- MLA ----------
Ramhorst, R., Calo, G., Paparini, D., Vota, D., Hauk, V., Gallino, L., et al. "Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide" . Annals of the New York Academy of Sciences, vol. 1437, no. 1, 2019, pp. 15-21.
---------- VANCOUVER ----------
Ramhorst, R., Calo, G., Paparini, D., Vota, D., Hauk, V., Gallino, L., et al. Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide. Ann. New York Acad. Sci. 2019;1437(1):15-21.