Abstract:
Unlike their protein "roommates" and their nucleic acid "cousins," carbohydrates remain an enigmatic arm of biology. The central reason for the difficulty in fully understanding how carbohydrate structure and biological function are tied is the nontemplate nature of their synthesis and the resulting heterogeneity. The goal of this collection of expert reviews is to highlight what is known about how carbohydrates and their binding partners-the microbial (non-self), tumor (altered-self), and host (self)-cooperate within the immune system, while also identifying areas of opportunity to those willing to take up the challenge of understanding more about how carbohydrates influence immune responses. In the end, these reviews will serve as specific examples of how carbohydrates are as integral to biology as are proteins, nucleic acids, and lipids. Here, we attempt to summarize general concepts on glycans and glycan-binding proteins (mainly C-type lectins, siglecs, and galectins) and their contributions to the biology of immune responses in physiologic and pathologic settings. © 2012 New York Academy of Sciences.
Registro:
Documento: |
Artículo
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Título: | Glycobiology of immune responses |
Autor: | Rabinovich, G.A.; van Kooyk, Y.; Cobb, B.A. |
Filiación: | Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina Laboratorio de Glicómica Funcional, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428 Ciudad de Buenos Aires, Argentina Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, Netherlands Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States
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Palabras clave: | C-type lectins; Galectins; Glycans; Glycobiology; Glycoimmunology; Lectins; Siglecs; binding protein; carbohydrate; galectin; glycan; glycan binding protein; glycoprotein; lectin; lipid; major histocompatibility antigen class 2; nucleic acid; nucleotide binding oligomerization domain like receptor; unclassified drug; autoimmunity; chronic inflammation; glycobiology; human; Human immunodeficiency virus; immune response; immune system; innate immunity; nonhuman; pathogenesis; protein expression; review; tumor immunity |
Año: | 2012
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Volumen: | 1253
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Número: | 1
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Página de inicio: | 1
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Página de fin: | 15
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DOI: |
http://dx.doi.org/10.1111/j.1749-6632.2012.06492.x |
Título revista: | Annals of the New York Academy of Sciences
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Título revista abreviado: | Ann. New York Acad. Sci.
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ISSN: | 00778923
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CODEN: | ANYAA
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CAS: | lipid, 66455-18-3
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1253_n1_p1_Rabinovich |
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Citas:
---------- APA ----------
Rabinovich, G.A., van Kooyk, Y. & Cobb, B.A.
(2012)
. Glycobiology of immune responses. Annals of the New York Academy of Sciences, 1253(1), 1-15.
http://dx.doi.org/10.1111/j.1749-6632.2012.06492.x---------- CHICAGO ----------
Rabinovich, G.A., van Kooyk, Y., Cobb, B.A.
"Glycobiology of immune responses"
. Annals of the New York Academy of Sciences 1253, no. 1
(2012) : 1-15.
http://dx.doi.org/10.1111/j.1749-6632.2012.06492.x---------- MLA ----------
Rabinovich, G.A., van Kooyk, Y., Cobb, B.A.
"Glycobiology of immune responses"
. Annals of the New York Academy of Sciences, vol. 1253, no. 1, 2012, pp. 1-15.
http://dx.doi.org/10.1111/j.1749-6632.2012.06492.x---------- VANCOUVER ----------
Rabinovich, G.A., van Kooyk, Y., Cobb, B.A. Glycobiology of immune responses. Ann. New York Acad. Sci. 2012;1253(1):1-15.
http://dx.doi.org/10.1111/j.1749-6632.2012.06492.x