Abstract:
Highly sophisticated mechanisms confer upon the immune system the capacity to respond with a certain degree of autonomy. However, the final outcome of an adaptative immune response depends on the interaction with other systems of the organism. The immune-neuroendocrine systems have an intimate cross-communication, making possible a satisfactory response to environmental changes. Part of this interaction occurs through cytokines and steroid hormones. The last step of this crosstalk is at the molecular level. In this article we will focus on the physical and functional interrelationship between cytokine signaling pathway-activated transcription factors (TFs) and steroid receptors in different cell models, where the signals triggered by cytokines and steroid hormones have major roles: (1) the ligand-dependent-activated glucocorticoid receptor (GR) influence the genetic program that specifies lineage commitment in T helper (Th) cell differentiation. How posttranslational modifications of several TFs as well as nuclear hormone receptors could be implicated in the molecular crosstalk between the immune-neuroendocrine messengers is discussed. (2) glucocorticoid (GC) antagonism on the TCR-induced T cell apoptosis. (3) estrogen receptor/TGF-β family proteins molecular interaction implicated on pituitary prolactinomas pathogenesis. The functional crosstalk at the molecular level between immune and steroids signals is essential to determine an integrative response to both mediators (which in the last instance results in a new gene activation/repression profile) and constitutes the ultimate integrative level of interaction between the immune and neuroendocrine systems. © 2006 New York Academy of Sciences.
Registro:
Documento: |
Artículo
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Título: | Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases |
Autor: | Druker, J.; Liberman, A.C.; Acuña, M.; Giacomini, D.; Refojo, D.; Silberstein, S.; Pereda, M.P.; Stalla, G.K.; Holsboer, F.; Arzt, E. |
Filiación: | Laboratorio de Fisiología Y Biología Molecular, Departamento de Fisiología Y Biología Molecular Y Celular, Pabellón II, (C1428EHA), Buenos Aires, Argentina IFYBINE-Argentine National Research Council (CONICET), Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina Affectis Pharmaceuticals, Kraepelinstrasse 2, 80804 Munich, Germany Max-Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany Laboratorio de Fisiología Y Biología Molecular, FCEN-Universidad de Buenos Aires, Pabellón II, (C1428EHA), Buenos Aires, Argentina
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Palabras clave: | Apoptosis; BMP-4; cAMP; Estrogens; GATA-3; Glucocorticoids; Prolactinoma; T-bet; TCR; TGF-β; Th1-Th2 differentiation; cytokine; estrogen receptor; glucocorticoid receptor; steroid hormone; transcription factor; transforming growth factor beta; cytokine; steroid; apoptosis; cell differentiation; conference paper; gene activation; gene repression; helper cell; immune response; neuroendocrine system; pathogenesis; protein interaction; signal transduction; T lymphocyte; human; immunology; immunomodulation; metabolism; neurosecretion; review; Cytokines; Humans; Neuroimmunomodulation; Neurosecretory Systems; Steroids |
Año: | 2006
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Volumen: | 1088
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Página de inicio: | 297
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Página de fin: | 306
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DOI: |
http://dx.doi.org/10.1196/annals.1366.007 |
Título revista: | Annals of the New York Academy of Sciences
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Título revista abreviado: | Ann. New York Acad. Sci.
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ISSN: | 00778923
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CODEN: | ANYAA
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CAS: | Cytokines; Steroids
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1088_n_p297_Druker |
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Citas:
---------- APA ----------
Druker, J., Liberman, A.C., Acuña, M., Giacomini, D., Refojo, D., Silberstein, S., Pereda, M.P.,..., Arzt, E.
(2006)
. Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases. Annals of the New York Academy of Sciences, 1088, 297-306.
http://dx.doi.org/10.1196/annals.1366.007---------- CHICAGO ----------
Druker, J., Liberman, A.C., Acuña, M., Giacomini, D., Refojo, D., Silberstein, S., et al.
"Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases"
. Annals of the New York Academy of Sciences 1088
(2006) : 297-306.
http://dx.doi.org/10.1196/annals.1366.007---------- MLA ----------
Druker, J., Liberman, A.C., Acuña, M., Giacomini, D., Refojo, D., Silberstein, S., et al.
"Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases"
. Annals of the New York Academy of Sciences, vol. 1088, 2006, pp. 297-306.
http://dx.doi.org/10.1196/annals.1366.007---------- VANCOUVER ----------
Druker, J., Liberman, A.C., Acuña, M., Giacomini, D., Refojo, D., Silberstein, S., et al. Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases. Ann. New York Acad. Sci. 2006;1088:297-306.
http://dx.doi.org/10.1196/annals.1366.007