Abstract:
Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diabetes in nonobese diabetic (NOD) mice, an annual model of type 1 diabetes. Mice treated with VIP from 4 weeks of age did not develop diabetes and showed milder insulitis than nontreated mice. The protective mechanism of VIP was associated with a reduction in the circulating levels of Th1 cytokines. In the pancreas of VIP-treated animals, regulatory T cell markers predominate, as indicated by the upregulation of FoxP3 and transforming growth factor-β (TGF-β), and the downregulation of the transcription factor, T-bet. These findings indicate that VIP restores tolerance to pancreatic islets by promoting the local differentiation and function of regulatory T cells. © 2006 New York Academy of Sciences.
Registro:
Documento: |
Artículo
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Título: | VIP and tolerance induction in autoimmunity |
Autor: | Rosignoli, F.; Torroba, M.; Juarranz, Y.; García-Gómez, M.; Martinez, C.; Gomariz, R.P.; Pérez-Leirós, C.; Leceta, J. |
Filiación: | Dept. Biología Celular, Facultad de Biologia, UCM, Madrid, Spain Dept. Biología Celular, Facultad de Medicina, UCM, Madrid, Spain Dept. Quimica Biologica, Facultad de Ciencias Naturales Y Exactas, UBA-CONICET, Buenos Aires, Argentina Dept. Biología Celular, Facultad de Biologia, UCM, 28040 Madrid, Spain
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Palabras clave: | Autoimmune; FoxP3; TGF-β; VIP; cytokine; transcription factor; transcription factor T bet; transforming growth factor beta; vasoactive intestinal polypeptide; animal experiment; animal model; autoimmunity; cell differentiation; cell function; conference paper; controlled study; down regulation; drug mechanism; female; insulin dependent diabetes mellitus; insulitis; mouse; nonhuman; pancreas; pancreas islet; regulatory T lymphocyte; Th1 cell; upregulation; Animalia |
Año: | 2006
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Volumen: | 1070
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Página de inicio: | 525
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Página de fin: | 530
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DOI: |
http://dx.doi.org/10.1196/annals.1317.073 |
Título revista: | Annals of the New York Academy of Sciences
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Título revista abreviado: | Ann. New York Acad. Sci.
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ISSN: | 00778923
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CODEN: | ANYAA
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CAS: | vasoactive intestinal polypeptide, 37221-79-7
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1070_n_p525_Rosignoli |
Referencias:
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Citas:
---------- APA ----------
Rosignoli, F., Torroba, M., Juarranz, Y., García-Gómez, M., Martinez, C., Gomariz, R.P., Pérez-Leirós, C.,..., Leceta, J.
(2006)
. VIP and tolerance induction in autoimmunity. Annals of the New York Academy of Sciences, 1070, 525-530.
http://dx.doi.org/10.1196/annals.1317.073---------- CHICAGO ----------
Rosignoli, F., Torroba, M., Juarranz, Y., García-Gómez, M., Martinez, C., Gomariz, R.P., et al.
"VIP and tolerance induction in autoimmunity"
. Annals of the New York Academy of Sciences 1070
(2006) : 525-530.
http://dx.doi.org/10.1196/annals.1317.073---------- MLA ----------
Rosignoli, F., Torroba, M., Juarranz, Y., García-Gómez, M., Martinez, C., Gomariz, R.P., et al.
"VIP and tolerance induction in autoimmunity"
. Annals of the New York Academy of Sciences, vol. 1070, 2006, pp. 525-530.
http://dx.doi.org/10.1196/annals.1317.073---------- VANCOUVER ----------
Rosignoli, F., Torroba, M., Juarranz, Y., García-Gómez, M., Martinez, C., Gomariz, R.P., et al. VIP and tolerance induction in autoimmunity. Ann. New York Acad. Sci. 2006;1070:525-530.
http://dx.doi.org/10.1196/annals.1317.073