Artículo
Rosignoli, F.; Torroba, M.; Juarranz, Y.; García-Gómez, M.; Martinez, C.; Gomariz, R.P.; Pérez-Leirós, C.; Leceta, J. "VIP and tolerance induction in autoimmunity" (2006) Annals of the New York Academy of Sciences. 1070:525-530
Consulte la política de Acceso Abierto del editor
Abstract:
Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diabetes in nonobese diabetic (NOD) mice, an annual model of type 1 diabetes. Mice treated with VIP from 4 weeks of age did not develop diabetes and showed milder insulitis than nontreated mice. The protective mechanism of VIP was associated with a reduction in the circulating levels of Th1 cytokines. In the pancreas of VIP-treated animals, regulatory T cell markers predominate, as indicated by the upregulation of FoxP3 and transforming growth factor-β (TGF-β), and the downregulation of the transcription factor, T-bet. These findings indicate that VIP restores tolerance to pancreatic islets by promoting the local differentiation and function of regulatory T cells. © 2006 New York Academy of Sciences.
Registro:
| Documento: | Artículo |
| Título: | VIP and tolerance induction in autoimmunity |
| Autor: | Rosignoli, F.; Torroba, M.; Juarranz, Y.; García-Gómez, M.; Martinez, C.; Gomariz, R.P.; Pérez-Leirós, C.; Leceta, J. |
| Filiación: | Dept. Biología Celular, Facultad de Biologia, UCM, Madrid, Spain Dept. Biología Celular, Facultad de Medicina, UCM, Madrid, Spain Dept. Quimica Biologica, Facultad de Ciencias Naturales Y Exactas, UBA-CONICET, Buenos Aires, Argentina Dept. Biología Celular, Facultad de Biologia, UCM, 28040 Madrid, Spain |
| Palabras clave: | Autoimmune; FoxP3; TGF-β; VIP; cytokine; transcription factor; transcription factor T bet; transforming growth factor beta; vasoactive intestinal polypeptide; animal experiment; animal model; autoimmunity; cell differentiation; cell function; conference paper; controlled study; down regulation; drug mechanism; female; insulin dependent diabetes mellitus; insulitis; mouse; nonhuman; pancreas; pancreas islet; regulatory T lymphocyte; Th1 cell; upregulation; Animalia |
| Año: | 2006 |
| Volumen: | 1070 |
| Página de inicio: | 525 |
| Página de fin: | 530 |
| DOI: | http://dx.doi.org/10.1196/annals.1317.073 |
| Título revista: | Annals of the New York Academy of Sciences |
| Título revista abreviado: | Ann. New York Acad. Sci. |
| ISSN: | 00778923 |
| CODEN: | ANYAA |
| CAS: | vasoactive intestinal polypeptide, 37221-79-7 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1070_n_p525_Rosignoli |
Referencias:
- Koarada, S., Wu, Y., Olshansky, G., Increased nonobese diabetic Th1:Th2 (IFN-:IL-4) ratio is CD4 T cell intrinsic and independent of APC genetic background (2002) J. Immunol., 169, pp. 6580-6587
- Mathisen, P.M., Tuohy, V.K., Gene therapy in the treatment of autoimmune disease (1998) Immunol. Today, 19, pp. 103-105
- Ryu, S., Kodama, S., Ryu, K., Reversal of established autoimmune diabetes by restoration of endogenous b cell function (2001) J. Clin. Invest., 108, pp. 63-72
- Gomariz, R.P., Martinez, C., Abad, C., Immunology of VIP: A review and therapeutical perspectives (2001) Curr. Pharm. Des., 7, pp. 89-111
- Delgado, M., Leceta, J., Ganea, D., Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide promote in vivo generation of memory Th2 cells (2002) FASEB J., 16, pp. 1844-1846
- Delgado, M., Abad, C., Martinez, C., Vasoactive intestinal peptide in the immune system: Potential therapeutic role in inflammatory and autoimmune diseases (2002) J. Mol. Med., 80, pp. 16-24
- Schloot, N.C., Hanifi-Moghaddam, P., Goebel, C., Serum IFN-g and IL-10 levels are associated with disease progression in non-obese diabetic mice (2002) Diabetes Metab. Res. Rev., 18, pp. 64-70
- Liew, F.Y., TH1 and TH2 cells: A historical perspective (2002) Nat. Rev. Immunol., 2, pp. 55-60
- Tominaga, Y., Nagata, M., Yasuda, H., Administration of IL-4 prevents autoimmune diabetes but enhances pancreatic insulitis in NOD mice (1998) Clin. Immunol. Immunopathol., 86, pp. 209-218
- Trembleau, S., Penna, G., Gregori, S., IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-γ-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-γ (2003) J. Immunol., 170, pp. 5491-5501
- Serreze, D.V., Chapman, H.D., Post, C.M., Th1 to Th2 cytokine shifts in nonobese diabetic mice: Sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation (2001) J. Immunol., 166, pp. 1352-1359
- Kukreja, A., Cost, G., Marker, J., Multiple immuno-regulatory defects in type-1 diabetes (2002) J. Clin. Invest., 109, pp. 131-140
- Hori, S., Nomura, T., Sakaguchi, S., Control of regulatory T cell development by the transcription factor FoxP3 (2003) Science, 299, pp. 1057-1061
- Zheng, S.G., Wang, J.H., Gray, J.D., Natural and induced CD4+CD25+ cells educate CD4+CD25+ cells to develop suppressive activity: The role of IL-2, TGF-β, and IL-10 (2004) J. Immunol., 172, pp. 5213-5221
Citas:
---------- APA ----------
Rosignoli, F., Torroba, M., Juarranz, Y., García-Gómez, M., Martinez, C., Gomariz, R.P., Pérez-Leirós, C.,..., Leceta, J. (2006) . VIP and tolerance induction in autoimmunity. Annals of the New York Academy of Sciences, 1070, 525-530.http://dx.doi.org/10.1196/annals.1317.073
---------- CHICAGO ----------
Rosignoli, F., Torroba, M., Juarranz, Y., García-Gómez, M., Martinez, C., Gomariz, R.P., et al. "VIP and tolerance induction in autoimmunity" . Annals of the New York Academy of Sciences 1070 (2006) : 525-530.http://dx.doi.org/10.1196/annals.1317.073
---------- MLA ----------
Rosignoli, F., Torroba, M., Juarranz, Y., García-Gómez, M., Martinez, C., Gomariz, R.P., et al. "VIP and tolerance induction in autoimmunity" . Annals of the New York Academy of Sciences, vol. 1070, 2006, pp. 525-530.http://dx.doi.org/10.1196/annals.1317.073
---------- VANCOUVER ----------
Rosignoli, F., Torroba, M., Juarranz, Y., García-Gómez, M., Martinez, C., Gomariz, R.P., et al. VIP and tolerance induction in autoimmunity. Ann. New York Acad. Sci. 2006;1070:525-530.http://dx.doi.org/10.1196/annals.1317.073
