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De Nicola, A.F.; Labombarda, F.; Gonzalez, S.L.; Gonzalez Deniselle, M.C.; Guennoun, R.; Schumacher, M. "Steroid Effects on Glial Cells: Detrimental or Protective for Spinal Cord Function?" (2003) Annals of the New York Academy of Sciences. 1007:317-328
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Abstract:

Repair of damage and recovery of function are fundamental endeavors for recuperation of patients and experimental animals with spinal cord injury. Steroid hormones, such as progesterone (PROG), show regenerative and myelinating properties following injury of the peripheral and central nervous system. In this work, we studied PROG effects on glial cells of the normal and transected (TRX) spinal cord, to complement previous studies in motoneurons. Both neurons and glial cells expressed the classical PROG receptor (PR), suggesting that genomic mechanisms participated in PROG action. In TRX rats, PROG treatment stimulated the number of NADPH-diaphorase (nitric oxide synthase) active astrocytes, whereas the number of astrocytes expressing the glial fibrillary acidic protein (GFAP) was stimulated in control but not in TRX rats. PROG also stimulated the immunocytochemical staining for myelin-basic protein (MBP) and the number of oligodendrocyte precursor cells expressing the chondroitin sulfate proteoglycan NG2 in TRX rats. In terms of beneficial or detrimental consequences, these PROG effects may be supportive of neuronal recuperation, as shown for several neuronal functional parameters that were normalized by PROG treatment of spinal cord injured animals. Thus, PROG effects on glial cells go in parallel with morphological and biochemical evidence of survival of damaged motoneurons.

Registro:

Documento: Artículo
Título:Steroid Effects on Glial Cells: Detrimental or Protective for Spinal Cord Function?
Autor:De Nicola, A.F.; Labombarda, F.; Gonzalez, S.L.; Gonzalez Deniselle, M.C.; Guennoun, R.; Schumacher, M.
Filiación:Inst. de Biol. y Med. Experimental, Department of Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
INSERM U488, Hôpital de Bicêtre, 94276 Bicêtre, France
Inst. de Biol. y Med. Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Astrocytes; Glial fibrillary acidic protein; Myelin basic protein; Neuroprotection; NG2 cells; Nitric oxide synthase; Oligodendrocytes; Progesterone; Spinal cord injury; glial fibrillary acidic protein; myelin basic protein; nitric oxide synthase; progesterone; progesterone receptor; proteochondroitin sulfate; reduced nicotinamide adenine dinucleotide phosphate dehydrogenase; steroid; animal cell; animal experiment; animal model; animal tissue; astrocyte; cell activation; cell count; cell damage; cell structure; cell survival; conference paper; controlled study; enzyme activation; genomics; glia cell; hormone determination; immunocytochemistry; male; motoneuron; neuroprotection; nonhuman; oligodendroglia; rat; spinal cord function; spinal cord injury; spinal cord transsection; Animalia
Año:2003
Volumen:1007
Página de inicio:317
Página de fin:328
DOI: http://dx.doi.org/10.1196/annals.1286.030
Título revista:Annals of the New York Academy of Sciences
Título revista abreviado:Ann. New York Acad. Sci.
ISSN:00778923
CODEN:ANYAA
CAS:nitric oxide synthase, 125978-95-2; progesterone, 57-83-0; reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, 9001-68-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1007_n_p317_DeNicola

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Citas:

---------- APA ----------
De Nicola, A.F., Labombarda, F., Gonzalez, S.L., Gonzalez Deniselle, M.C., Guennoun, R. & Schumacher, M. (2003) . Steroid Effects on Glial Cells: Detrimental or Protective for Spinal Cord Function?. Annals of the New York Academy of Sciences, 1007, 317-328.
http://dx.doi.org/10.1196/annals.1286.030
---------- CHICAGO ----------
De Nicola, A.F., Labombarda, F., Gonzalez, S.L., Gonzalez Deniselle, M.C., Guennoun, R., Schumacher, M. "Steroid Effects on Glial Cells: Detrimental or Protective for Spinal Cord Function?" . Annals of the New York Academy of Sciences 1007 (2003) : 317-328.
http://dx.doi.org/10.1196/annals.1286.030
---------- MLA ----------
De Nicola, A.F., Labombarda, F., Gonzalez, S.L., Gonzalez Deniselle, M.C., Guennoun, R., Schumacher, M. "Steroid Effects on Glial Cells: Detrimental or Protective for Spinal Cord Function?" . Annals of the New York Academy of Sciences, vol. 1007, 2003, pp. 317-328.
http://dx.doi.org/10.1196/annals.1286.030
---------- VANCOUVER ----------
De Nicola, A.F., Labombarda, F., Gonzalez, S.L., Gonzalez Deniselle, M.C., Guennoun, R., Schumacher, M. Steroid Effects on Glial Cells: Detrimental or Protective for Spinal Cord Function?. Ann. New York Acad. Sci. 2003;1007:317-328.
http://dx.doi.org/10.1196/annals.1286.030