Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Background: Recent MADIT II and SCD-HeFT trials have led to an expansion of indications for use of prophylactic Implantable Cardioverter Defibrillator (ICD) in patients with severe left-ventricular impairment. This therapy has not been fully adopted in our health care system, mainly due to its high cost. Objective: To assess total mortality of SCD-HeFT-like patients from our daily practice who are under stable, optimal medical treatment and who have not received an ICD; and to compare it to that of the placebo arm of the SCD-HeFT Trial. Methods: SCD-HeFT-like patients identified from office medical records were included in our study. Total mortality was assessed by telephone contact. Statistical analysis was performed by Student's t-Test, Mann-Whitney Test or χ2 test, depending on the type of variable. Cumulative mortality rates were calculated according to the Kaplan-Meier method. Results: Our study comprised 102 patients (seventy-four of which were men) with a median age of 64 years, and an overall median ejection fraction of 25%. We found no differences between our patients and SCD-HeFT patients across these 3 variables. Over a 19.6-month follow-up period, 21 patients died (20.6%) vs 28.8% of the SCD-HeFT patients. This difference was not statistically significant (p = 0.08). Conclusion: SCD-HeFT-like patients from our practice had no difference in mortality rate than patients enrolled in the placebo arm of the SCD-HeFT trial. These results suggest that the SCD-HeFT population is representative of our patients.

Registro:

Documento: Artículo
Título:Long-term follow-up of patients with indication for a implantable defibrillator for primary prevention of death
Autor:Hadid, C.; Avellana, P.; Di Toro, D.; Gomez, C.F.; Visser, M.; Prieto, N.
Filiación:Hospital Donación Francisco Santojanni, Buenos Aires, Argentina
Arcos, 2252 4 B, Belgrano, 1428, Buenos Aires, Argentina
Palabras clave:Death, sudden; Defibrillators, implantable; Heart failure, congestive/mortality; adult; aged; article; clinical practice; congestive heart failure; controlled study; defibrillator; disease severity; female; follow up; health care cost; health care system; heart left ventricle failure; human; long term care; major clinical study; male; mortality; teleconsultation; treatment outcome; Aged; Argentina; Death, Sudden, Cardiac; Defibrillators, Implantable; Epidemiologic Methods; Female; Heart Failure; Humans; Male; Middle Aged; Placebo Effect; Randomized Controlled Trials as Topic; Treatment Outcome; Ventricular Dysfunction, Left
Año:2008
Volumen:90
Número:5
Página de inicio:311
Página de fin:315+339-344
DOI: http://dx.doi.org/10.1590/S0066-782X2008000500006
Título revista:Arquivos Brasileiros de Cardiologia
Título revista abreviado:Arq. Bras. Cardiol.
ISSN:0066782X
CODEN:ABCAA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0066782X_v90_n5_p311_Hadid

Referencias:

  • A randomized trial of beta blockade in heart failure: The Cardiac Insufficiency Bisoprolol Study (CIBIS) (1994) Circulation, 90, pp. 1765-1773. , CIBIS Investigators and Committees
  • The Cardiac Insufficiency Bisoprolol Study (CIBIS II): A randomized trial (1999) Lancet, 353, pp. 9-13. , CIBIS II Investigators and Committees
  • Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL: randomized intervention trial in congestive heart failure (MERIT-HF) (1999) Lancet, 353, pp. 2001-2007. , MERIT-HF Investigators
  • Packer, M., Coats, A.J., Fowler, M.B., Katus, H., Krum, H., Mohacsi, P., Effect of carvedilol on survival in severe chronic heart failure (2001) N Engl J Med, 344, pp. 1651-1658
  • Doval H, Ferrante D. Meta-analysis of trials of beta-blockers in heart failure. In: Doval HY, Tajer C. Evidencias en cardiología IV. 4th. ed. GEDIC; 2005. p. 445-70; Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS) (1987) N Engl J Med, 316, pp. 1429-1435. , The CONSENSUS Trial Study Group
  • Effect of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure (1991) N Engl J Med, 325, pp. 293-302. , The SOLVD Investigators
  • Garg, R., Yusuf, S., Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure (1995) JAMA, 273, pp. 1450-1456. , for the Collaborative Group on ACE Inhibitor Trials
  • Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure (1993) Lancet, 342, pp. 821-828. , The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators
  • Pitt, B., Zannad, F., Remme, W.J., Cody, R., Castaigne, A., Perez, A., The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study (RALES) Investigators (1999) N Engl J Med, 341, pp. 709-717
  • Pitt, B., Remme, W., Zannad, F., Neaton, J., Martinez, F., Roniker, B., Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. EPHESUS Trial (2003) N Engl J Med, 348, pp. 1309-1321
  • Singh, S.N., Fletcher, R.D., Fisher, S.G., Singh, B.N., Lewis, H.D., Deedwania, P.C., Survival trial of Antiarrhythmic Therapy in Congestive Heart Failure (CHF-STAT). Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia (1995) N Engl J Med, 333, pp. 77-82
  • Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: Meta-analysis of individual data from 6500 patients in randomized trials (1997) Lancet, 350, pp. 1417-1424. , Amiodarone Trials Meta Analysis Investigators
  • Doval, H., Nul, D., Grancelli, H., Perrone, S., Bortman, G., Curiel, R., Randomized trial of low-dose amiodarone in severe congestive heart failure. Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina (GESICA) (1994) Lancet, 344, pp. 493-498
  • Bardy, G., Lee, K., Mark, D., Poole, J., Packer, D., Boineau, R., Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. The Sudden Cardiac Death in Heart Failure (SCD-HeFT) Trial (2005) N Engl J Med, 352, pp. 225-237
  • Moss, A., Zareba, W., Jackson Hall, W., Klein, H., Wilber, D., Cannom, D., Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction (2002) N Eng J Med, 346, pp. 877-883. , for the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II Investigators
  • ACC/AHA/ESC 2006 Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death. J Am Coll Cardiol. 2006; 48: 1064-108; A comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from near fatal ventricular arrhythmias (1997) N Engl J Med, 337, pp. 1576-1583. , The Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators
  • Connolly, S., Gent, M., Roberts, R., Dorian, P., Roy, D., Sheldon, R., Canadian implantable defibrillator study (CIDS): A randomized trial of the implantable cardioverter defibrillator against amiodarone (2000) Circulation, 101, pp. 1297-1302
  • Kuck, K., Cappato, R., Siebels, J., Ruppel, R., Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest. The Cardiac Arrest Study Hamburg (CASH) (2000) Circulation, 102, pp. 748-754. , for the CASH Investigators
  • Moss, A., Hall, W., Cannom, D., Daubert, J., Higgins, S., Klein, H., Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators (1996) N Eng J Med, 335, pp. 1933-1940
  • Buxton, A., Lee, K., Fisher, J., Josephson, M., Prystowsky, E., Hafley, A randomized study of the prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial Investigators (1999) N Engl J Med, 341, pp. 1882-1890
  • Brodsky, M., Mitchell, L., Halperin, B., Raitt, M., Hallstrom, A., AVID Investigators. Prognostic value of baseline electrophysiology studies in patients with sustained ventricular tachyarrhythmia: The Antiarrhythmics Versus Implantable Defibrillators (AVID) Trial (2002) Am Heart J, 144, pp. 478-484
  • Wilber, D., Garan, H., Finkelstein, D., Kelly, E., Newell, J., McGovern, B., Out-of-hospital cardiac arrest: Use of electrophysiologic testing in the prediction of long-term outcome (1988) N Engl J Med, 318, pp. 19-24
  • Roy, D., Waxman, H., Kienzle, M., Buxton, A., Marchlinski, M., Josephson, M., Clinical characteristics and long-term follow up of 119 survivors of out-of-hospital cardiac arrest: Relation to inducibility at electrophysiologic testing (1983) Am J Cardiol, 52, pp. 969-974
  • Daubert, J., Zareba, W., Hall, J., Schuger, C., Corsello, A., Leon, A., Predictive value of ventricular arrhythmia inducibility for subsequent ventricular tachycardia or ventricular fibrillation in multicenter automatic defibrillator implantation trial (MADIT) II patients (2006) J Am Coll Cardiol, 47, pp. 98-107
  • Buxton, A., Lee, K., Hafley, G., Wyse, G., Fisher, J., Lehmann, M., Relation of ejection fraction and inducible ventricular tachycardia to mode of death in patients with coronary artery disease: An analysis of patients enrolled in the Multicenter Unsustained Tachycardia Trial (2002) Circulation, 106, pp. 2466-2472. , for the MUSTT Investigators
  • Strickberger, S., Hummel, J., Bartlett, T., Frumin, H., Schuger, C., Beau, S., Amiodarone versus implantable cardioverter-defibrillator: Randomized trial in patients with nonischemic dilated cardiomyopathy and asymptomatic nonsustained ventricular tachycardia - AMIOVIRT (2003) J Am Coll Cardiol, 41, pp. 1707-1712
  • Kadish, A., Dyer, A., Daubert, J., Quigg, R., Estes, N., Anderson, K., Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy (2004) N Engl J Med, 350, pp. 2151-2158. , for the Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators
  • Komajda, M., Follath, F., Swedberg, K., Cleland, J., Aguilar, J.C., Cohen-Solal, A., The EuroHeart Failure Survey programme - a survey on the quality of care among patients with heart failure in Europe. Part 2: Treatment (2003) Eur Heart J, 24, pp. 464-474. , for the Study Group on Diagnosis of the Working Group on Heart Failure of the European Society of Cardiology
  • Brodine, W.N., Tung, R.T., Lee, J.K., Hockstad, E.S., Moss, A.J., Zareba, W., Effects of beta-blockers on implantable cardioverter defibrillator therapy and survival in the patients ischemic Cardiomyopathy (from the Multicenter Automatic Defibrillator Implantation Trial-II) (2005) Am J Cardiol, 96, pp. 691-695. , for the MADIT II Research Group
  • Toal, S., Harris, L., Asta, J., Hill, A., Cameron, D., Routine defibrillation threshold testing at implant in patients receiving defibrillators for primary prevention: Is this necessary? (Abstract) (2006) Heart Rhythm, 3, pp. S157
  • Mark, D.B., Nelson, C.L., Anstrom, K.J., Al-Khatib, S.M., Tsiatis, A.A., Cowper, P.A., Cost-effectiveness of defibrillator therapy or amiodarone in chronic stable heart failure (2006) Circulation, 114, pp. 135-142. , for the SCD-HeFT Investigators

Citas:

---------- APA ----------
Hadid, C., Avellana, P., Di Toro, D., Gomez, C.F., Visser, M. & Prieto, N. (2008) . Long-term follow-up of patients with indication for a implantable defibrillator for primary prevention of death . Arquivos Brasileiros de Cardiologia, 90(5), 311-315+339-344.
http://dx.doi.org/10.1590/S0066-782X2008000500006
---------- CHICAGO ----------
Hadid, C., Avellana, P., Di Toro, D., Gomez, C.F., Visser, M., Prieto, N. "Long-term follow-up of patients with indication for a implantable defibrillator for primary prevention of death " . Arquivos Brasileiros de Cardiologia 90, no. 5 (2008) : 311-315+339-344.
http://dx.doi.org/10.1590/S0066-782X2008000500006
---------- MLA ----------
Hadid, C., Avellana, P., Di Toro, D., Gomez, C.F., Visser, M., Prieto, N. "Long-term follow-up of patients with indication for a implantable defibrillator for primary prevention of death " . Arquivos Brasileiros de Cardiologia, vol. 90, no. 5, 2008, pp. 311-315+339-344.
http://dx.doi.org/10.1590/S0066-782X2008000500006
---------- VANCOUVER ----------
Hadid, C., Avellana, P., Di Toro, D., Gomez, C.F., Visser, M., Prieto, N. Long-term follow-up of patients with indication for a implantable defibrillator for primary prevention of death . Arq. Bras. Cardiol. 2008;90(5):311-315+339-344.
http://dx.doi.org/10.1590/S0066-782X2008000500006