Abstract:
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific features, normal cell functioning, and responses of eukaryotic cells to external cues. Its importance is confirmed by the evolutionary conservation and diversification of alternative splicing and the fact that its deregulation causes hereditary disease and cancer. This review discusses the multiple layers of cotranscriptional regulation of alternative splicing in which chromatin structure, DNA methylation, histone marks, and nucleosome positioning play a fundamental role in providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence for how the kinetics of RNA polymerase II (RNAPII) elongation and the recruitment of splicing factors and adaptor proteins to chromatin components act in coordination to regulate alternative splicing. Copyright © 2015 by Annual Reviews. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Regulation of alternative splicing through coupling with transcription and chromatin structure |
Autor: | Naftelberg, S.; Schor, I.E.; Ast, G.; Kornblihtt, A.R. |
Filiación: | Sackler Medical School, Tel Aviv University, Tel Aviv, 69978, Israel Instituto de Fisiología, Biología Molecular y Neurociencias, Departamento de Fisiología, Biología Molecular y Celular, Ciudad Universitaria, Buenos Aires, C1428EHA, Argentina
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Palabras clave: | Alternative splicing; Chromatin organization; Histone modifications; Molecular evolution; Nucleosome positioning; Transcription; adaptor protein; histone; RNA polymerase II; chromatin; nucleosome; alternative RNA splicing; chromatin structure; density; DNA methylation; histone modification; human; kinetics; machine; nonhuman; nucleosome; priority journal; Review; animal; biological model; chromatin; gene expression regulation; genetic transcription; metabolism; protein processing; Eukaryota; Alternative Splicing; Animals; Chromatin; DNA Methylation; Gene Expression Regulation; Histones; Humans; Models, Genetic; Nucleosomes; Protein Processing, Post-Translational; Transcription, Genetic |
Año: | 2015
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Volumen: | 84
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Página de inicio: | 165
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Página de fin: | 198
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DOI: |
http://dx.doi.org/10.1146/annurev-biochem-060614-034242 |
Título revista: | Annual Review of Biochemistry
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Título revista abreviado: | Annu. Rev. Biochem.
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ISSN: | 00664154
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CODEN: | ARBOA
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CAS: | histone, 9062-68-4; Chromatin; Histones; Nucleosomes
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664154_v84_n_p165_Naftelberg |
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Citas:
---------- APA ----------
Naftelberg, S., Schor, I.E., Ast, G. & Kornblihtt, A.R.
(2015)
. Regulation of alternative splicing through coupling with transcription and chromatin structure. Annual Review of Biochemistry, 84, 165-198.
http://dx.doi.org/10.1146/annurev-biochem-060614-034242---------- CHICAGO ----------
Naftelberg, S., Schor, I.E., Ast, G., Kornblihtt, A.R.
"Regulation of alternative splicing through coupling with transcription and chromatin structure"
. Annual Review of Biochemistry 84
(2015) : 165-198.
http://dx.doi.org/10.1146/annurev-biochem-060614-034242---------- MLA ----------
Naftelberg, S., Schor, I.E., Ast, G., Kornblihtt, A.R.
"Regulation of alternative splicing through coupling with transcription and chromatin structure"
. Annual Review of Biochemistry, vol. 84, 2015, pp. 165-198.
http://dx.doi.org/10.1146/annurev-biochem-060614-034242---------- VANCOUVER ----------
Naftelberg, S., Schor, I.E., Ast, G., Kornblihtt, A.R. Regulation of alternative splicing through coupling with transcription and chromatin structure. Annu. Rev. Biochem. 2015;84:165-198.
http://dx.doi.org/10.1146/annurev-biochem-060614-034242