Artículo

de Lederkremer, R.M.; Agusti, R. "Chapter 7 Glycobiology of Trypanosoma cruzi" (2009) Advances in Carbohydrate Chemistry and Biochemistry. 62:311-366
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Abstract:

The glycobiology of Trypanosoma cruzi, the causative agent of Chagas' disease, has contributed significantly to the identification of target enzymes responsible for the construction of unique cell-surface molecules. The authors discuss the structure of glycoinositolphospholipids, both free and as protein anchors in T. cruzi. The presence is emphasized of structural motifs that are absent in mammals. These include galactofuranose, aminoethylphosphonic acid, and inositolphosphoceramide. The mucins and the trans-sialidase (TcTS), both of which are involved in the infection process, are reviewed in detail in this chapter. The chemical synthesis of the oligosaccharides containing Galf is presented, as well as the use of the TcTS for synthetic purposes. © 2009 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Chapter 7 Glycobiology of Trypanosoma cruzi
Autor:de Lederkremer, R.M.; Agusti, R.
Filiación:CHIDECAR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Pabellon II, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:Chagas' disease; Galactofuranose; Glycoinositolphospholipids; GPI anchors; Inositolphosphoceramide; Mucins; trans-Sialidase; Trypanosoma cruzi; alditol; amino acid; antigen; carbohydrate; glycoconjugate; glycoprotein; lactose; mucin; phospholipid; protein; sialic acid derivative; sialidase; membrane protein; binding site; carbohydrate analysis; catalysis; cell surface; genetic variability; glycobiology; insect; life cycle; nonhuman; parasite; priority journal; review; sialylation; Trypanosoma cruzi; animal; biosynthesis; chemistry; growth, development and aging; immunology; metabolism; molecular genetics; Mammalia; Trypanosoma cruzi; Animals; Carbohydrate Sequence; Glycoconjugates; Glycomics; Life Cycle Stages; Membrane Glycoproteins; Molecular Sequence Data; Trypanosoma cruzi
Año:2009
Volumen:62
Página de inicio:311
Página de fin:366
DOI: http://dx.doi.org/10.1016/S0065-2318(09)00007-9
Título revista:Advances in Carbohydrate Chemistry and Biochemistry
Título revista abreviado:Adv. Carbohydr. Chem. Biochem.
ISSN:00652318
CODEN:ACBYA
CAS:amino acid, 65072-01-7; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; protein, 67254-75-5; sialidase, 9001-67-6; Glycoconjugates; Membrane Glycoproteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00652318_v62_n_p311_deLederkremer

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Citas:

---------- APA ----------
de Lederkremer, R.M. & Agusti, R. (2009) . Chapter 7 Glycobiology of Trypanosoma cruzi. Advances in Carbohydrate Chemistry and Biochemistry, 62, 311-366.
http://dx.doi.org/10.1016/S0065-2318(09)00007-9
---------- CHICAGO ----------
de Lederkremer, R.M., Agusti, R. "Chapter 7 Glycobiology of Trypanosoma cruzi" . Advances in Carbohydrate Chemistry and Biochemistry 62 (2009) : 311-366.
http://dx.doi.org/10.1016/S0065-2318(09)00007-9
---------- MLA ----------
de Lederkremer, R.M., Agusti, R. "Chapter 7 Glycobiology of Trypanosoma cruzi" . Advances in Carbohydrate Chemistry and Biochemistry, vol. 62, 2009, pp. 311-366.
http://dx.doi.org/10.1016/S0065-2318(09)00007-9
---------- VANCOUVER ----------
de Lederkremer, R.M., Agusti, R. Chapter 7 Glycobiology of Trypanosoma cruzi. Adv. Carbohydr. Chem. Biochem. 2009;62:311-366.
http://dx.doi.org/10.1016/S0065-2318(09)00007-9