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Kordich, L.C.; Porterie, V.P.; Lago, O.; Bergonzelli, G.E.; Sassetti, B.; Sanchez Avalos, J.C. "Mini-plasminogen like molecule in septic patients" (1987) Thrombosis Research. 47(5):553-560
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Abstract:

Plasma from 7 septic patients with positive blood cultures were studied. None of them presented either clinical or laboratory evidence of Disseminated Intravascular Coagulation. The white cells count varied between 5 and 45×109/l. In plasma functional plasminogen levels varied between 25 and 45%, while those of α2-antiplasmin were normal (80-105%). The levels of elastase ranged between 250 and 750 ug/ml. Leukocyte elastase digests plasminogen "in vitro" and is able to produce several fragments; one of them called mini-plasminogen lacking lysine binding sites; therefore it does not bind to lysine-Sepharose 4B. Two different behaviors were observed in the plasmatic plasminogen of these patients with respect to their binding capacity to lysine-Sepharose 4 B. 3 patients had plasminogen which did not bind to lysine-Sepharose 4 B; the other 4 had two different components, one of which bound to lysine-Sepharose 4 B and another one which did not bind. Previous studies "in vitro" have shown that leukocyte elastase modifies α2-antiplasmin, initially producing a non-plasminogen binding form. A free α2-antiplasmin (non-plasminogen binding form) was detected in the plasma of these patients with sepsis by crossed immunoelectrophoresis with plasminogen in the first dimension. It seems tenable that high levels of leukocyte elastase could be responsible for these findings although, the possible relationships to leukocyte elastase still remain to be proven but could possibly explain this effect. © 1987.

Registro:

Documento: Artículo
Título:Mini-plasminogen like molecule in septic patients
Autor:Kordich, L.C.; Porterie, V.P.; Lago, O.; Bergonzelli, G.E.; Sassetti, B.; Sanchez Avalos, J.C.
Filiación:Departament of Biological Chemistry. Facultad de Ciencias Exactas, Naturales. Universidad de Buenos Aires, Argentina
Departament of Hematology. Hospital Privado GUemes, Buenos Aires, Argentina
Palabras clave:mini-plasminogen; sepsis; α2-antiplasmin; alpha 2 antiplasmin; elastase; miniplasminogen; unclassified drug; article; blood and hemopoietic system; etiology; human; human cell; leukocyte; sepsis; alpha 1-Antitrypsin; Antiplasmin; Blood Proteins; Humans; Leukocytes; Pancreatic Elastase; Plasminogen; Sepsis
Año:1987
Volumen:47
Número:5
Página de inicio:553
Página de fin:560
DOI: http://dx.doi.org/10.1016/0049-3848(87)90360-4
Título revista:Thrombosis Research
Título revista abreviado:Thromb. Res.
ISSN:00493848
CODEN:THBRA
CAS:elastase, 9004-06-2; Antiplasmin; Blood Proteins; Pancreatic Elastase, 3.4.21.36; Plasminogen, 9001-91-6; alpha 1-Antitrypsin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v47_n5_p553_Kordich

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Citas:

---------- APA ----------
Kordich, L.C., Porterie, V.P., Lago, O., Bergonzelli, G.E., Sassetti, B. & Sanchez Avalos, J.C. (1987) . Mini-plasminogen like molecule in septic patients. Thrombosis Research, 47(5), 553-560.
http://dx.doi.org/10.1016/0049-3848(87)90360-4
---------- CHICAGO ----------
Kordich, L.C., Porterie, V.P., Lago, O., Bergonzelli, G.E., Sassetti, B., Sanchez Avalos, J.C. "Mini-plasminogen like molecule in septic patients" . Thrombosis Research 47, no. 5 (1987) : 553-560.
http://dx.doi.org/10.1016/0049-3848(87)90360-4
---------- MLA ----------
Kordich, L.C., Porterie, V.P., Lago, O., Bergonzelli, G.E., Sassetti, B., Sanchez Avalos, J.C. "Mini-plasminogen like molecule in septic patients" . Thrombosis Research, vol. 47, no. 5, 1987, pp. 553-560.
http://dx.doi.org/10.1016/0049-3848(87)90360-4
---------- VANCOUVER ----------
Kordich, L.C., Porterie, V.P., Lago, O., Bergonzelli, G.E., Sassetti, B., Sanchez Avalos, J.C. Mini-plasminogen like molecule in septic patients. Thromb. Res. 1987;47(5):553-560.
http://dx.doi.org/10.1016/0049-3848(87)90360-4