Abstract:
We report a case of partial deficiency of α2-antiplasmin. A 45 year old Spanish man had a life long severe bleeding tendency after trauma. Routine coagulation and platelet functional tests in symptomatic and asymptomatic periods were normal. During the bleeding there was a rapid whole blood clot lysis and the concentration of α2-antiplasmin in plasma was 20 to 25 % of normal controls. After recovery these levels showed a slight increase (35 to 45 % of normal). Addition of normal plasma to the patient's plasma increased α2-plasmin inhibitor activity. Bidimensional electrophoresis of α2-antiplasmin in the patient's plasma showed a normal pattern. Family studies showed that one of the proband'R two sons had a mild hemorrhagic tendency and 140 % of functional and antigenic levels of α2-antiplasmin. © 1985.
Registro:
Documento: |
Artículo
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Título: | Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency |
Autor: | Kordich, L.; Feldman, L.; Porterie, P.; Lago, O. |
Filiación: | Hospital Privado Güemes, Buenos Aires, Argentina Facultad de Ciencias Exactas, Naturales. Universidad de Buenos Aires, Argentina Hospital Ramon Sanmartina. Universidad Nacional, Centro de la Provincia de Buenos Aires, Tandil, Argentina
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Palabras clave: | Hemorrhagic tendency; Heterozygous; α2-Antiplasmin deficiency; alpha 2 antiplasmin; bleeding disorder; blood and hemopoietic system; case report; enzyme deficiency; fibrinolysis; human; priority journal; Antiplasmin; Blood Coagulation Factors; Blood Coagulation Tests; Case Report; Fibrinolysis; Hemorrhage; Heterozygote; Human; Male; Middle Age; Platelet Count; Platelet Function Tests; Reference Values |
Año: | 1985
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Volumen: | 40
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Número: | 5
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Página de inicio: | 645
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Página de fin: | 651
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DOI: |
http://dx.doi.org/10.1016/0049-3848(85)90302-0 |
Título revista: | Thrombosis Research
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Título revista abreviado: | Thromb. Res.
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ISSN: | 00493848
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CODEN: | THBRA
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CAS: | Antiplasmin; Blood Coagulation Factors
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v40_n5_p645_Kordich |
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Citas:
---------- APA ----------
Kordich, L., Feldman, L., Porterie, P. & Lago, O.
(1985)
. Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency. Thrombosis Research, 40(5), 645-651.
http://dx.doi.org/10.1016/0049-3848(85)90302-0---------- CHICAGO ----------
Kordich, L., Feldman, L., Porterie, P., Lago, O.
"Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency"
. Thrombosis Research 40, no. 5
(1985) : 645-651.
http://dx.doi.org/10.1016/0049-3848(85)90302-0---------- MLA ----------
Kordich, L., Feldman, L., Porterie, P., Lago, O.
"Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency"
. Thrombosis Research, vol. 40, no. 5, 1985, pp. 645-651.
http://dx.doi.org/10.1016/0049-3848(85)90302-0---------- VANCOUVER ----------
Kordich, L., Feldman, L., Porterie, P., Lago, O. Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency. Thromb. Res. 1985;40(5):645-651.
http://dx.doi.org/10.1016/0049-3848(85)90302-0