Molinas, F.C.; Drucker, E.; Kordich, L.; Alvarez Reynolds, M.; Finkielman, S. "Platelet function and antithrombins in hyperlipoproteinemia type IIa" (1981) Thrombosis Research. 22(4):427-435
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Platelet function was studied in 35 patients with type IIa hyperlipoproteinemia and 22 normal controls. Platelet aggregation by ADP in concentrations ranging from 2×10-6 to 2×10-5 M, and adrenaline 10-6 M were similar in both groups. In contrast, aggregation induced by collagen and secondary aggregation elicited by bovine factor VIII were significantly lower in hypercholesterolemic patients, who also disclosed an increased plasmatic antiheparin activity. This plasmatic antiheparin activity was inversely correlated to plasmatic cholesterol concentration, (r = -0.50, p<0.01). PF3 and PF4 were normal in patients with type IIa hyperlipoproteinemia. AntiFXa, antithrombin III, and heparin cofactor were also determined. Heparin cofactor was found to be significantly lower in hypercholesterolemic patients than in controls, and inversely correlated to plasmatic cholesterol concentration (r = -0.51, p<0.05). These observations suggest that the thrombotic tendency in hypercholesterolemia may be related to a decrease of plasmatic heparin cofactor. © 1981.


Documento: Artículo
Título:Platelet function and antithrombins in hyperlipoproteinemia type IIa
Autor:Molinas, F.C.; Drucker, E.; Kordich, L.; Alvarez Reynolds, M.; Finkielman, S.
Filiación:Instituto de Investigaciones Médicas, Facultad de Medicina, Donato Alvarez 3150, y Cátedra de Análisis Clínicos, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1427 Buenos Aires, Argentina
Palabras clave:antithrombins; hyperlipoproteinemia; platelet aggregation; antithrombin; cholesterol; heparin; blood and hemopoietic system; etiology; human cell; hyperlipoproteinemia type 2a; in vitro study; thrombocyte aggregation; Adenosine Diphosphate; Adult; Antithrombins; Blood Coagulation; Blood Platelets; Calcium; Cholesterol; Epinephrine; Female; Heparin Antagonists; Humans; Hyperlipoproteinemia Type II; Male; Middle Aged; Platelet Aggregation; Thromboplastin
Página de inicio:427
Página de fin:435
Título revista:Thrombosis Research
Título revista abreviado:Thromb. Res.
CAS:antithrombin, 9000-94-6; cholesterol, 57-88-5; heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5; Adenosine Diphosphate, 58-64-0; Antithrombins; Calcium, 7440-70-2; Cholesterol, 57-88-5; Epinephrine, 51-43-4; Heparin Antagonists; Thromboplastin, 9035-58-9


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---------- APA ----------
Molinas, F.C., Drucker, E., Kordich, L., Alvarez Reynolds, M. & Finkielman, S. (1981) . Platelet function and antithrombins in hyperlipoproteinemia type IIa. Thrombosis Research, 22(4), 427-435.
---------- CHICAGO ----------
Molinas, F.C., Drucker, E., Kordich, L., Alvarez Reynolds, M., Finkielman, S. "Platelet function and antithrombins in hyperlipoproteinemia type IIa" . Thrombosis Research 22, no. 4 (1981) : 427-435.
---------- MLA ----------
Molinas, F.C., Drucker, E., Kordich, L., Alvarez Reynolds, M., Finkielman, S. "Platelet function and antithrombins in hyperlipoproteinemia type IIa" . Thrombosis Research, vol. 22, no. 4, 1981, pp. 427-435.
---------- VANCOUVER ----------
Molinas, F.C., Drucker, E., Kordich, L., Alvarez Reynolds, M., Finkielman, S. Platelet function and antithrombins in hyperlipoproteinemia type IIa. Thromb. Res. 1981;22(4):427-435.