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Abstract:

Alterations in the synthesis or enhanced inactivation of nitric oxide (NO) and an increase in endothelin-1 production lead to an imbalance that can induce arterial hypertension. Type II diabetes is characterized by impaired endothelium-dependent vasodilation and vascular disease. NO is produced through L-arginine pathway by three different isoforms of nitric oxide synthase (NOS), an inducible form that can be activated by cytokines such as tumor necrosis factor α (TNFα). We evaluated NO plasmatic levels, endothelial damage markers such as von Willebrand factor (vWF), platelet activation, soluble P-selectin (sP-Sel), TNFα levels, insulinaemia (I), glycosylated haemoglobin (HbA1c), glycaemia and blood pressure in 32 hypertensive diabetic type II patients (Group A), 37 hypertensive patients (Group B) and 35 healthy subjects (Group C) matched in sex, age, body mass index and dietary habits. The level of I was increased in patients compared to the controls and correlated with their NO levels. vWF plasmatic levels were increased in Group A compared to Groups B and C. We also found significant differences in platelet activation among all the groups. In diabetic patients, increased NO levels correlated with TNFα, HbA1c and platelet activation showed greater endothelial damage than in Group B. These parameters described a prothrombotic state associated with an insulin resistance state, an increased vWF release, raised sP-Sel and TNFα levels and, maybe, low NO bioavailability, which could lead to a higher risk of development of thrombotic events in hypertensive diabetic patients (Group A) than in the hypertensive patients in Group B. © 2001 Elsevier Science Ltd.

Registro:

Documento: Artículo
Título:Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic type II patients
Autor:Ouvia, S.M.; La Greca, R.D.; Zanaro, N.L.; Palmer, L.; Sassetti, B.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Hospital Churruca Visca, Buenos Aires, Argentina
Departamento de Qumica, Biolgica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II, Piso, 1428 Buenos Aires, Argentina
Palabras clave:Diabetes; Endothelial dysfunction; Hypertension; Nitric oxide; Platelet activation; von Willebrand factor; arginine; endothelin 1; glycosylated hemoglobin; nitric oxide; nitric oxide synthase; PADGEM protein; tumor necrosis factor alpha; von Willebrand factor; adult; aged; article; bioavailability; blood pressure; body mass; controlled study; diet; disease marker; endothelium lesion; enzyme activation; female; glucose blood level; human; hypertension; insulin blood level; insulin resistance; insulinemia; major clinical study; male; non insulin dependent diabetes mellitus; priority journal; protein blood level; thrombocyte activation; vasodilatation; Aged; Blood Pressure; Case-Control Studies; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Platelet Activation; Thrombophilia; Tumor Necrosis Factor-alpha; von Willebrand Factor
Año:2001
Volumen:102
Número:2
Página de inicio:107
Página de fin:114
DOI: http://dx.doi.org/10.1016/S0049-3848(01)00237-7
Título revista:Thrombosis Research
Título revista abreviado:Thromb. Res.
ISSN:00493848
CODEN:THBRA
CAS:Nitric Oxide, 10102-43-9; Tumor Necrosis Factor-alpha; von Willebrand Factor
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v102_n2_p107_Ouvia

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Citas:

---------- APA ----------
Ouvia, S.M., La Greca, R.D., Zanaro, N.L., Palmer, L. & Sassetti, B. (2001) . Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic type II patients. Thrombosis Research, 102(2), 107-114.
http://dx.doi.org/10.1016/S0049-3848(01)00237-7
---------- CHICAGO ----------
Ouvia, S.M., La Greca, R.D., Zanaro, N.L., Palmer, L., Sassetti, B. "Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic type II patients" . Thrombosis Research 102, no. 2 (2001) : 107-114.
http://dx.doi.org/10.1016/S0049-3848(01)00237-7
---------- MLA ----------
Ouvia, S.M., La Greca, R.D., Zanaro, N.L., Palmer, L., Sassetti, B. "Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic type II patients" . Thrombosis Research, vol. 102, no. 2, 2001, pp. 107-114.
http://dx.doi.org/10.1016/S0049-3848(01)00237-7
---------- VANCOUVER ----------
Ouvia, S.M., La Greca, R.D., Zanaro, N.L., Palmer, L., Sassetti, B. Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic type II patients. Thromb. Res. 2001;102(2):107-114.
http://dx.doi.org/10.1016/S0049-3848(01)00237-7