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Murúa, A.L.; Quintana, I.; Janson, J.; Batista, M.; Camera, M.I.; Kordich, L.C. "Plasmatic homocysteine response to vitamin supplementation in elderly people" (2000) Thrombosis Research. 100(6):495-500
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Abstract:

Homocysteine (Hcy) increase is now widely accepted as a risk factor for vascular disease. The effects of folic acid (FA) and vitamins B12 and B6 in lowering Hcy have been extensively studied, but there is still little data on the response to FA dietary administration. Our purpose was to evaluate the impact of the diet and the degree of response to different doses of pharmacological FA supplementation. In a prospective, randomized, and simple blind study, 50 elderly subjects were given a 400-μg/day FA diet and were randomly assigned to one of the following treatments: Group I=placebo tablet; Group II=tablet containing 1-mg folic acid, 1-mg B12, and 25-mg B6; and Group III=tablet containing 2.5-mg folic acid and same B6 and B12 doses as Group II. Forty-four subjects completed the study, and their plasmas were evaluated. Hcy concentration significantly decreased even in patients with normal basal values, and there were no differences in the response between individuals receiving diet plus placebo and those receiving diet plus pharmacological supplementation. After the treatment, the mean decrease of plasmatic Hcy levels was 10.8 (9.4, 12.5) μmol/l, geometric mean [95% confidence interval (95% CI)], and particularly, the values for Group I were 10.6 (7.4, 14.8) μmol/l. In 31% of the subjects, the post-treatment Hcy levels were ≤5 μmol/l. These results show that a special diet, with or without pharmacological FA and B12 and B6 supplementation, significantly decreases the Hcy levels in elderly people. Therefore, a diet with high contents of FA might have an enormous impact on the morbidity and mortality of atherothrombosis. © 2000 Elsevier Science Ltd.

Registro:

Documento: Artículo
Título:Plasmatic homocysteine response to vitamin supplementation in elderly people
Autor:Murúa, A.L.; Quintana, I.; Janson, J.; Batista, M.; Camera, M.I.; Kordich, L.C.
Filiación:Laboratorio de Hemostasia/Trombosis, Facultad de Cien. Exactas/Naturales, Univesidad de Buenos Aires, Ciudad Univ. CP1428, Buenos Aires, Argentina
Palabras clave:Diet; Elderly; Folic acid; Homocysteine; Vitamin treatment; folic acid; homocysteine; vitamin; article; atherogenesis; atherosclerosis; cardiovascular risk; clinical article; clinical trial; controlled clinical trial; controlled study; diet supplementation; drug effect; elderly care; female; human; male; priority journal; randomized controlled trial; risk factor; single blind procedure; thrombogenesis; thrombosis; vascular disease; vitamin supplementation; Aged; Aged, 80 and over; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Male; Statistics, Nonparametric; Vascular Diseases; Vitamins
Año:2000
Volumen:100
Número:6
Página de inicio:495
Página de fin:500
DOI: http://dx.doi.org/10.1016/S0049-3848(00)00360-1
Título revista:Thrombosis Research
Título revista abreviado:Thromb. Res.
ISSN:00493848
CAS:folic acid, 59-30-3, 6484-89-5; homocysteine, 454-28-4, 6027-13-0; Folic Acid, 59-30-3; Homocysteine, 454-28-4; Vitamins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v100_n6_p495_Murua

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Citas:

---------- APA ----------
Murúa, A.L., Quintana, I., Janson, J., Batista, M., Camera, M.I. & Kordich, L.C. (2000) . Plasmatic homocysteine response to vitamin supplementation in elderly people. Thrombosis Research, 100(6), 495-500.
http://dx.doi.org/10.1016/S0049-3848(00)00360-1
---------- CHICAGO ----------
Murúa, A.L., Quintana, I., Janson, J., Batista, M., Camera, M.I., Kordich, L.C. "Plasmatic homocysteine response to vitamin supplementation in elderly people" . Thrombosis Research 100, no. 6 (2000) : 495-500.
http://dx.doi.org/10.1016/S0049-3848(00)00360-1
---------- MLA ----------
Murúa, A.L., Quintana, I., Janson, J., Batista, M., Camera, M.I., Kordich, L.C. "Plasmatic homocysteine response to vitamin supplementation in elderly people" . Thrombosis Research, vol. 100, no. 6, 2000, pp. 495-500.
http://dx.doi.org/10.1016/S0049-3848(00)00360-1
---------- VANCOUVER ----------
Murúa, A.L., Quintana, I., Janson, J., Batista, M., Camera, M.I., Kordich, L.C. Plasmatic homocysteine response to vitamin supplementation in elderly people. Thromb. Res. 2000;100(6):495-500.
http://dx.doi.org/10.1016/S0049-3848(00)00360-1