Artículo

Carlini, M.J.; Dalurzo, M.C.L.; Lastiri, J.M.; Smith, D.E.; Vasallo, B.C.; Puricelli, L.I.; Lauría de Cidre, L.S. "Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance" (2010) Human Pathology. 41(5):697-705
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Abstract:

The impact of interstitial inflammatory cells, such as mast cells, and angiogenesis on the prognosis of cancer patients has been reported in many solid tumors, although there is disagreement about their role. We undertook a retrospective study with tissue samples from 65 patients with stage I and II non-small cell lung cancer to assess the clinical pathologic role and prognostic significance of mast cells. Mast cell phenotypes were identified by immunohistochemistry for tryptase and chymase. In addition, we identified microvessels using the endothelial marker CD34. Mast cell and microvessel density was quantified by assessing immunopositive cells in the intratumoral and peritumoral zones of tumor specimens. Both mast cell and microvessel density was higher in the peritumoral zone than the intratumoral zone (P ≤ .05). A positive correlation between mast cell (tryptase-chymase phenotype) and microvessel densities was observed in the intratumoral zone (P ≤ .05), supporting the involvement of mast cells in the angiogenic process. Regarding survival, a subset of stage I patients had a worse prognosis at five years when low mast cell (tryptase-chymase phenotype) density was found in the peritumoral zone (median survival in months [range]: 27 [1-60] versus 46 [1-60]). Multivariate Cox analysis indicated that this parameter may be an independent prognostic factor (P ≤ .05) useful for selecting candidates for earlier treatment. © 2010 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance
Autor:Carlini, M.J.; Dalurzo, M.C.L.; Lastiri, J.M.; Smith, D.E.; Vasallo, B.C.; Puricelli, L.I.; Lauría de Cidre, L.S.
Filiación:Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires C1428EGA, Argentina
Hospital Italiano de Buenos Aires, Buenos Aires, C1181ACH, Argentina
Instituto de Oncología Ángel H. Roffo Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, C1417DTB, Argentina
Palabras clave:Intratumoral; Lung cancer; Mast cell phenotypes; Microvessels; Peritumoral; CD34 antigen; chymase; tryptase; adult; aged; article; cancer survival; cell infiltration; controlled study; female; human; human tissue; immunohistochemistry; lung lobectomy; lung non small cell cancer; major clinical study; male; mast cell; microvasculature; phenotype; prognosis; Age Factors; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Chi-Square Distribution; Female; Humans; Immunohistochemistry; Lung; Lung Neoplasms; Male; Mast Cells; Microvessels; Middle Aged; Neoplasm Staging; Neovascularization, Pathologic; Prognosis; Proportional Hazards Models; Retrospective Studies; Statistics, Nonparametric
Año:2010
Volumen:41
Número:5
Página de inicio:697
Página de fin:705
DOI: http://dx.doi.org/10.1016/j.humpath.2009.04.029
Título revista:Human Pathology
Título revista abreviado:Hum. Pathol.
ISSN:00468177
CODEN:HPCQA
CAS:chymase, 75496-62-7, 97501-92-3; tryptase, 97501-93-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00468177_v41_n5_p697_Carlini

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Citas:

---------- APA ----------
Carlini, M.J., Dalurzo, M.C.L., Lastiri, J.M., Smith, D.E., Vasallo, B.C., Puricelli, L.I. & Lauría de Cidre, L.S. (2010) . Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance. Human Pathology, 41(5), 697-705.
http://dx.doi.org/10.1016/j.humpath.2009.04.029
---------- CHICAGO ----------
Carlini, M.J., Dalurzo, M.C.L., Lastiri, J.M., Smith, D.E., Vasallo, B.C., Puricelli, L.I., et al. "Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance" . Human Pathology 41, no. 5 (2010) : 697-705.
http://dx.doi.org/10.1016/j.humpath.2009.04.029
---------- MLA ----------
Carlini, M.J., Dalurzo, M.C.L., Lastiri, J.M., Smith, D.E., Vasallo, B.C., Puricelli, L.I., et al. "Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance" . Human Pathology, vol. 41, no. 5, 2010, pp. 697-705.
http://dx.doi.org/10.1016/j.humpath.2009.04.029
---------- VANCOUVER ----------
Carlini, M.J., Dalurzo, M.C.L., Lastiri, J.M., Smith, D.E., Vasallo, B.C., Puricelli, L.I., et al. Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance. Hum. Pathol. 2010;41(5):697-705.
http://dx.doi.org/10.1016/j.humpath.2009.04.029