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Abstract:

The individual and combined toxicities of chlortetracycline (CTC), oxytetracycline (OTC) and enrofloxacin (ENF) have been examined in two green algae representative of the freshwater environment, the international standard strain Pseudokichneriella subcapitata and the native strain Ankistrodesmus fusiformis. The toxicities of the three antibiotics and their mixtures were similar in both strains, although low concentrations of ENF and CTC + ENF were more toxic in A. fusiformis than in the standard strain. The toxicological interactions of binary mixtures were predicted using the two classical models of additivity: Concentration Addition (CA) and Independent Action (IA), and compared to the experimentally determined toxicities over a range of concentrations between 0.1 and 10 mg L−1. The CA model predicted the inhibition of algal growth in the three mixtures in P. subcapitata, and in the CTC + OTC and CTC + ENF mixtures in A. fusiformis. However, this model underestimated the experimental results obtained in the OTC + ENF mixture in A. fusiformis. The IA model did not predict the experimental toxicological effects of the three mixtures in either strain. The sum of the toxic units (TU) for the mixtures was calculated. According to these values, the binary mixtures CTC + ENF and OTC + ENF showed an additive effect, and the CTC + OTC mixture showed antagonism in P. subcapitata, whereas the three mixtures showed synergistic effects in A. fusiformis. Although A. fusiformis was isolated from a polluted river, it showed a similar sensitivity with respect to P. subcapitata when it was exposed to binary mixtures of antibiotics. © 2017 Elsevier Ltd

Registro:

Documento: Artículo
Título:Effects of three veterinary antibiotics and their binary mixtures on two green alga species
Autor:Carusso, S.; Juárez, A.B.; Moretton, J.; Magdaleno, A.
Filiación:Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Salud Pública e Higiene Ambiental, Junin 956, 4° Piso, Buenos Aires, AAC C1113, Argentina
Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental y Departamento de Química Biológica, Benos Aires, Argentina
CONICET-Universidad de Buenos Aires, Instituto de Biodiversidad y Biología Experimental y Aplicada (IBBEA), Buenos Aires, Argentina
Palabras clave:Binary mixtures; Chlortetracycline; Enrofloxacin; Oxytetracycline; Pseudokirchneriella subcapitata; Algae; Antibiotics; Toxicity; Chlortetracycline; Concentration addition; Enrofloxacin; Freshwater environments; International standards; Oxytetracyclines (OTC); Pseudokirchneriella subcapitata; Toxicological effects; Binary mixtures; antibiotic agent; chlortetracycline; enrofloxacin; oxytetracycline; veterinary drug; antiinfective agent; chlortetracycline; enrofloxacin; oxytetracycline; quinolone derivative; veterinary drug; antibiotics; concentration (composition); experimental study; freshwater environment; green alga; isolated population; river pollution; toxicity; algal growth; Ankistrodesmus fusiformis; Article; Chlorella pyrenoidosa; Chlorella vulgaris; concentration (parameters); Desmodesmus subspicatus; EC50; ecotoxicity; ecotoxicology; freshwater environment; green alga; IC50; nonhuman; Pseudokichneriella subcapitata; river; sea pollution; drug effects; drug interaction; green alga; limnology; algae; Ankistrodesmus fusiformis; Chlorophyta; Selenastrum capricornutum; Anti-Bacterial Agents; Chlorophyta; Chlortetracycline; Drug Interactions; Fluoroquinolones; Freshwater Biology; Oxytetracycline; Veterinary Drugs
Año:2018
Volumen:194
Página de inicio:821
Página de fin:827
DOI: http://dx.doi.org/10.1016/j.chemosphere.2017.12.047
Título revista:Chemosphere
Título revista abreviado:Chemosphere
ISSN:00456535
CODEN:CMSHA
CAS:chlortetracycline, 12691-62-2, 57-62-5, 64-72-2, 78794-02-2; enrofloxacin, 93106-60-6; oxytetracycline, 2058-46-0, 56761-42-3, 79-57-2; Anti-Bacterial Agents; Chlortetracycline; enrofloxacin; Fluoroquinolones; Oxytetracycline; Veterinary Drugs
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00456535_v194_n_p821_Carusso

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Citas:

---------- APA ----------
Carusso, S., Juárez, A.B., Moretton, J. & Magdaleno, A. (2018) . Effects of three veterinary antibiotics and their binary mixtures on two green alga species. Chemosphere, 194, 821-827.
http://dx.doi.org/10.1016/j.chemosphere.2017.12.047
---------- CHICAGO ----------
Carusso, S., Juárez, A.B., Moretton, J., Magdaleno, A. "Effects of three veterinary antibiotics and their binary mixtures on two green alga species" . Chemosphere 194 (2018) : 821-827.
http://dx.doi.org/10.1016/j.chemosphere.2017.12.047
---------- MLA ----------
Carusso, S., Juárez, A.B., Moretton, J., Magdaleno, A. "Effects of three veterinary antibiotics and their binary mixtures on two green alga species" . Chemosphere, vol. 194, 2018, pp. 821-827.
http://dx.doi.org/10.1016/j.chemosphere.2017.12.047
---------- VANCOUVER ----------
Carusso, S., Juárez, A.B., Moretton, J., Magdaleno, A. Effects of three veterinary antibiotics and their binary mixtures on two green alga species. Chemosphere. 2018;194:821-827.
http://dx.doi.org/10.1016/j.chemosphere.2017.12.047