Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The release of tritium by Latrodectus antheratus spider venom gland extract, high K+ and tyramine, were studied in two noradrenergically innervated tissues of the rat (the isolated hypothalamus and the perfused tail artery) preloaded with 3H-noradrenaline. An increase in 3H release by venom gland extract and by K+ was observed in the presence of phenoxybenzamine, an alpha-adrenoceptor blocker. In contrast, the release of 3H by tyramine, an indirect sympathomimetic amine whose action does not depend on the presence of calcium ions, was not modified. Methoxamine, an alpha-adrenoceptor agonist, decreased the 3H release by the venom gland extract and high K+. The results suggest that the venom gland extract releases noradrenaline by a process similar to that evoked by stimulation with high K+, i.e. via a depolarizing mechanism regulated by a negative feedback pathway involving alpha-adrenoceptors. © 1981.

Registro:

Documento: Artículo
Título:Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium
Autor:Pardal, J.F.; Granata, A.R.; Gimeno, A.L.; Barrio, A.
Filiación:Centro Nacional de Investigaciones Iológicas (CENAI), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET), Serrano 665, 1414 Buenos Aires, Argentina
Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET, V. de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:adrenergic receptor; alpha adrenergic receptor; methoxamine; phenoxybenzamine; phentolamine; potassium; radioisotope; tyramine; animal experiment; artery; arthropod; central nervous system; drug mechanism; hypothalamus; in vitro study; noradrenalin h 3; noradrenalin release; peripheral vascular system; phenoxamine; rat; spider; tail artery; venom gland extract; Animal; Arteries; Arthropod Venoms; Black Widow Spider; Female; Hypothalamus; In Vitro; Male; Methoxamine; Muscle, Smooth, Vascular; Norepinephrine; Phenoxybenzamine; Potassium; Rats; Spider Venoms; Support, Non-U.S. Gov't; Tyramine
Año:1981
Volumen:19
Número:2
Página de inicio:249
Página de fin:254
DOI: http://dx.doi.org/10.1016/0041-0101(81)90028-3
Título revista:Toxicon
Título revista abreviado:Toxicon
ISSN:00410101
CODEN:TOXIA
CAS:methoxamine, 390-28-3, 61-16-5; phenoxybenzamine, 59-96-1, 63-92-3; phentolamine, 50-60-2, 73-05-2; potassium, 7440-09-7; tyramine, 51-67-2, 60-19-5; Arthropod Venoms; Methoxamine, 390-28-3; Norepinephrine, 51-41-2; Phenoxybenzamine, 59-96-1; Potassium, 7440-09-7; Spider Venoms; Tyramine, 51-67-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00410101_v19_n2_p249_Pardal

Referencias:

  • Brown, Gillespie, The output of sympathetic transmitter from the spleen of the cat (1957) J. Physiol. Lond., 138, p. 81
  • Burn, Gibbons, The part played by calcium in determining the response to stimulation of sympathetic postganglionic fibres (1964) Br. J. Pharmac., 22, p. 540
  • Farah, Adler-Graschinsky, Langer, Possible physiological significance of the initial step in the catabolism of noradrenaline in the central nervous system of the rat (1977) Naunyn-Schmiedeberg's Archs Pharmac., 297, p. 119
  • Farnebo, Hamberger, Drug induced changes in the release of 3H-monoamines from field stimulated rat brain slices (1971) Acta Physiologica Scandinavica, p. 35
  • Fernández Pardal, Fernández Pardal, Dextro-phenylalanine as inhibitor of the noradrenaline release by the isolated rat hypothalamus (1979) Acta Neurol. Lat. Amer., 25, p. 235
  • Fernández Pardal, Granata, Barrio, Influence of calcium on 3H-noradrenaline release by Latrodectus antheratus (black widow spider) venom gland extract in arterial tissues of the rat (1979) Toxicon, 17, p. 455
  • Fernández Pardal, Granata, Barrio, Gimeno, Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands (1980) Naunyn-Schmiedeberg's Archives of Pharmacology, 313, p. 27
  • Glowinski, Iversen, Regional studies of 3H-noradrenaline, 3H-dopamine and 3H-DOPA in various regions of the brain (1966) J. Neurochem., 13, p. 655
  • Granata, Barrio, Effects of Latrodectus mactans spider venom on the isolated perfused cat spleen (1978) Toxins—Animal, Plant and Microbial, p. 661. , P. Rosenberg, Pergamon Press, Oxford
  • Kirpekar, Misu, Release of noradrenaline by splenic nerve stimulation and its dependence on calcium (1967) J. Physiol., Lond., 188, p. 219
  • Kirpekar, Puig, Effect of flow-stop on noradrenaline release from normal spleens and spleens treated with cocaine, phentolamine or phenoxybenzamine (1971) Br. J. Pharmac., 43, p. 359
  • Kirpekar, Wakade, Release of noradrenaline from the cat spleen by potassium (1968) J. Physiol., Lond., 194, p. 595
  • Kirpekar, Prat, Puig, Wakade, Modification of the evoked release of noradrenaline from the perfused cat spleen by various ions and agents (1972) J. Physiol., Lond., 221, p. 601
  • Snedecor, Cochran, (1967) Statistical Methods, , 6th Edn., The Iowa State University Press, Ames
  • Starke, Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart (1972) Naunyn-Schmiedeberg's Archs Pharmac., 274, p. 18
  • Starke, Regulation of noradrenaline release by presynaptic receptor systems (1977) Rev. Physiol. Biochem. Pharmac., 77, p. 1
  • Starke, Montel, Influence of drugs with affinity for alpha-adrenoceptors on noradrenaline-release by potassium, tyramine and dimethylphenylpiperazinium (1974) Eur. J. Pharmac., 27, p. 273
  • Stjarne, Comparison of secretion of sympathetic neurotransmitter induced by nerve stimulation with that evoked by high potassium, as triggers of dual alpha-adrenoceptor mediated negative feed-back control of noradrenaline secretion (1973) Prostaglandins, 3, p. 105
  • Taube, Starke, Borowski, Presynaptic receptor systems on the noradrenergic neurones of rat brain (1977) Naunyn-Schmiedeberg's Archs Pharmac., 299, p. 123

Citas:

---------- APA ----------
Pardal, J.F., Granata, A.R., Gimeno, A.L. & Barrio, A. (1981) . Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium. Toxicon, 19(2), 249-254.
http://dx.doi.org/10.1016/0041-0101(81)90028-3
---------- CHICAGO ----------
Pardal, J.F., Granata, A.R., Gimeno, A.L., Barrio, A. "Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium" . Toxicon 19, no. 2 (1981) : 249-254.
http://dx.doi.org/10.1016/0041-0101(81)90028-3
---------- MLA ----------
Pardal, J.F., Granata, A.R., Gimeno, A.L., Barrio, A. "Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium" . Toxicon, vol. 19, no. 2, 1981, pp. 249-254.
http://dx.doi.org/10.1016/0041-0101(81)90028-3
---------- VANCOUVER ----------
Pardal, J.F., Granata, A.R., Gimeno, A.L., Barrio, A. Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium. Toxicon. 1981;19(2):249-254.
http://dx.doi.org/10.1016/0041-0101(81)90028-3