Artículo

Barreiro, K.A.; Di Yorio, M.P.; Artillo-Guida, R.D.; Paz, D.A.; Faletti, A.G. "Daily treatment with α-naphthoflavone enhances follicular growth and ovulation rate in the rat" (2011) Toxicology and Applied Pharmacology. 252(1):11-17
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Abstract:

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and the first protein involved in a variety of physiological and toxicological processes, including those of xenobiotic metabolizing enzymes. AhR has been found in the ovary of many species and seems to mediate the ovarian toxicity of many environmental contaminants, which are AhR ligands. However, the role of AhR in the ovarian function is unknown. Therefore, the aim of this work was to study the action of α-naphthoflavone (αNF), known to be an AhR antagonist, on both follicular growth and ovulation. Immature Sprague-Dawley rats were daily injected intraperitoneally with αNF (0.1-80. mg/kg) or vehicle for 12. days, and primed with gonadotrophins (eCG/hCG) to induce follicular growth and ovulation. Ovaries were obtained 20. h after hCG administration. By means of immunohistochemistry, we found that the numbers of primordial, primary and antral follicles were increased in rats treated with 80. mg/kg αNF and that there were no differences with other doses. Likewise, the ovarian weight and the ovulation rate, measured by both number of oocytes within oviducts and corpora lutea in ovarian sections, were increased when the rats received either 1 or 10. mg/kg daily. Although further studies are necessary to know the mechanism of action of αNF, it is possible that the different ovarian processes can be differentially responsive to the presence of different levels of αNF, and that the same or different endogenous AhR ligands can be involved in these ovarian processes in a cell type-dependent manner. © 2011 Elsevier Inc.

Registro:

Documento: Artículo
Título:Daily treatment with α-naphthoflavone enhances follicular growth and ovulation rate in the rat
Autor:Barreiro, K.A.; Di Yorio, M.P.; Artillo-Guida, R.D.; Paz, D.A.; Faletti, A.G.
Filiación:Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET), I Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 16 P, (C1121ABG) CABA, Argentina
Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE- CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II, 4 P, (C1428EHA) CABA, Argentina
Palabras clave:α-naphthoflavone; AhR; Follicular growth; Ovulation; alpha naphthoflavone; chorionic gonadotropin; animal experiment; animal tissue; article; corpus luteum; drug mechanism; female; immunohistochemistry; nonhuman; oocyte; organ weight; ovary; ovary follicle development; oviduct; ovulation; rat; Animals; Benzoflavones; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Ovarian Follicle; Ovulation; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Rattus
Año:2011
Volumen:252
Número:1
Página de inicio:11
Página de fin:17
DOI: http://dx.doi.org/10.1016/j.taap.2011.01.007
Título revista:Toxicology and Applied Pharmacology
Título revista abreviado:Toxicol. Appl. Pharmacol.
ISSN:0041008X
CODEN:TXAPA
CAS:alpha naphthoflavone, 604-59-1; chorionic gonadotropin, 9002-61-3; Benzoflavones; Receptors, Aryl Hydrocarbon; alpha-naphthoflavone, 604-59-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0041008X_v252_n1_p11_Barreiro

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Citas:

---------- APA ----------
Barreiro, K.A., Di Yorio, M.P., Artillo-Guida, R.D., Paz, D.A. & Faletti, A.G. (2011) . Daily treatment with α-naphthoflavone enhances follicular growth and ovulation rate in the rat. Toxicology and Applied Pharmacology, 252(1), 11-17.
http://dx.doi.org/10.1016/j.taap.2011.01.007
---------- CHICAGO ----------
Barreiro, K.A., Di Yorio, M.P., Artillo-Guida, R.D., Paz, D.A., Faletti, A.G. "Daily treatment with α-naphthoflavone enhances follicular growth and ovulation rate in the rat" . Toxicology and Applied Pharmacology 252, no. 1 (2011) : 11-17.
http://dx.doi.org/10.1016/j.taap.2011.01.007
---------- MLA ----------
Barreiro, K.A., Di Yorio, M.P., Artillo-Guida, R.D., Paz, D.A., Faletti, A.G. "Daily treatment with α-naphthoflavone enhances follicular growth and ovulation rate in the rat" . Toxicology and Applied Pharmacology, vol. 252, no. 1, 2011, pp. 11-17.
http://dx.doi.org/10.1016/j.taap.2011.01.007
---------- VANCOUVER ----------
Barreiro, K.A., Di Yorio, M.P., Artillo-Guida, R.D., Paz, D.A., Faletti, A.G. Daily treatment with α-naphthoflavone enhances follicular growth and ovulation rate in the rat. Toxicol. Appl. Pharmacol. 2011;252(1):11-17.
http://dx.doi.org/10.1016/j.taap.2011.01.007