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Abstract:

Novel 10-{[3-(6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)- 4,5-dihydro-5-isoxazolyl]methyl}-9(10H)-acridinone derivatives (13-16) were synthesized by 1,3-dipolar cycloaddition using the carbohydrate derivative as dipole and different 10-allyl-9(10H)-acridinone derivatives (9-12) as dipolarophiles. The new cycloadducts as well as the dipolarophiles precursors were characterized spectroscopically. Copyright © Taylor & Francis Group, LLC.

Registro:

Documento: Artículo
Título:Synthesis of novel carbohydrate acridinone derivatives with potential biological activities using 1,3-dipolar cycloaddition
Autor:Fascio, M.L.; D'Accorso, N.B.; Pellón, R.F.; Docampo, M.L.
Filiación:CIHIDECAR-CONICET, Department of Organic Chemistry, FCEyN-Buenos Aires University, Buenos Aires, Argentina
Center of Pharmaceutical Chemistry, Havana, Cuba
Faculty of Exact and Natural Science, Department of Organic Chemistry, Ciudad Universitaria, Buenos Aires, Argentina
Palabras clave:1,3-dipolar cycloaddition; Acridinones; Carbohydrates; Isoxazolines; N-allylation; 10 [[3 (6 hydroxy 2,2 dimethyltetrahydrofuro[2,3 d][1,3]dioxol 5 yl) 4,5 dihydro 5 isoxazolyl]methyl] 4 methoxy 9(10h) acridinone; 10 [[3 (6 hydroxy 2,2 dimethyltetrahydrofuro[2,3 d][1,3]dioxol 5 yl) 4,5 dihydro 5 isoxazolyl]methyl] 9(10h) acridinone; 10 allyl 3 chloro 5 methoxy 9(10h) acridinone; 10 allyl 3 chloro 9(10h) acridinone; 10 allyl 4 methoxy 9(10h) acridinone; 10 allyl 9(10h) acridinone; 3 chloro 10 [[3 ( hydroxy 2,2 dimethyltetrahydrofuro[2,3 d][1,3]dioxol 5 yl) 4,5 dihydro 5 isoxazolyl]methyl] 6 methoxy 9(10h) acridinone; 3 chloro 10 [[3 (6 hydroxy 2,2 dimethyltetrahydrofuro[2,3 d][1,3]dioxol 5 yl) 4,5 dihydro 5 isoxazolyl]methyl] 9(10h) acridinone; acridinone derivative; carbohydrate derivative; organic compound; unclassified drug; article; cycloaddition; drug activity; drug determination; drug structure; drug synthesis; spectroscopy; structure analysis
Año:2007
Volumen:37
Número:23
Página de inicio:4209
Página de fin:4217
DOI: http://dx.doi.org/10.1080/00397910701575178
Título revista:Synthetic Communications
Título revista abreviado:Synth. Commun.
ISSN:00397911
CODEN:SYNCA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00397911_v37_n23_p4209_Fascio

Referencias:

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Citas:

---------- APA ----------
Fascio, M.L., D'Accorso, N.B., Pellón, R.F. & Docampo, M.L. (2007) . Synthesis of novel carbohydrate acridinone derivatives with potential biological activities using 1,3-dipolar cycloaddition. Synthetic Communications, 37(23), 4209-4217.
http://dx.doi.org/10.1080/00397910701575178
---------- CHICAGO ----------
Fascio, M.L., D'Accorso, N.B., Pellón, R.F., Docampo, M.L. "Synthesis of novel carbohydrate acridinone derivatives with potential biological activities using 1,3-dipolar cycloaddition" . Synthetic Communications 37, no. 23 (2007) : 4209-4217.
http://dx.doi.org/10.1080/00397910701575178
---------- MLA ----------
Fascio, M.L., D'Accorso, N.B., Pellón, R.F., Docampo, M.L. "Synthesis of novel carbohydrate acridinone derivatives with potential biological activities using 1,3-dipolar cycloaddition" . Synthetic Communications, vol. 37, no. 23, 2007, pp. 4209-4217.
http://dx.doi.org/10.1080/00397910701575178
---------- VANCOUVER ----------
Fascio, M.L., D'Accorso, N.B., Pellón, R.F., Docampo, M.L. Synthesis of novel carbohydrate acridinone derivatives with potential biological activities using 1,3-dipolar cycloaddition. Synth. Commun. 2007;37(23):4209-4217.
http://dx.doi.org/10.1080/00397910701575178