Abstract:
Novel 10-{[3-(6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)- 4,5-dihydro-5-isoxazolyl]methyl}-9(10H)-acridinone derivatives (13-16) were synthesized by 1,3-dipolar cycloaddition using the carbohydrate derivative as dipole and different 10-allyl-9(10H)-acridinone derivatives (9-12) as dipolarophiles. The new cycloadducts as well as the dipolarophiles precursors were characterized spectroscopically. Copyright © Taylor & Francis Group, LLC.
Registro:
Documento: |
Artículo
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Título: | Synthesis of novel carbohydrate acridinone derivatives with potential biological activities using 1,3-dipolar cycloaddition |
Autor: | Fascio, M.L.; D'Accorso, N.B.; Pellón, R.F.; Docampo, M.L. |
Filiación: | CIHIDECAR-CONICET, Department of Organic Chemistry, FCEyN-Buenos Aires University, Buenos Aires, Argentina Center of Pharmaceutical Chemistry, Havana, Cuba Faculty of Exact and Natural Science, Department of Organic Chemistry, Ciudad Universitaria, Buenos Aires, Argentina
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Palabras clave: | 1,3-dipolar cycloaddition; Acridinones; Carbohydrates; Isoxazolines; N-allylation; 10 [[3 (6 hydroxy 2,2 dimethyltetrahydrofuro[2,3 d][1,3]dioxol 5 yl) 4,5 dihydro 5 isoxazolyl]methyl] 4 methoxy 9(10h) acridinone; 10 [[3 (6 hydroxy 2,2 dimethyltetrahydrofuro[2,3 d][1,3]dioxol 5 yl) 4,5 dihydro 5 isoxazolyl]methyl] 9(10h) acridinone; 10 allyl 3 chloro 5 methoxy 9(10h) acridinone; 10 allyl 3 chloro 9(10h) acridinone; 10 allyl 4 methoxy 9(10h) acridinone; 10 allyl 9(10h) acridinone; 3 chloro 10 [[3 ( hydroxy 2,2 dimethyltetrahydrofuro[2,3 d][1,3]dioxol 5 yl) 4,5 dihydro 5 isoxazolyl]methyl] 6 methoxy 9(10h) acridinone; 3 chloro 10 [[3 (6 hydroxy 2,2 dimethyltetrahydrofuro[2,3 d][1,3]dioxol 5 yl) 4,5 dihydro 5 isoxazolyl]methyl] 9(10h) acridinone; acridinone derivative; carbohydrate derivative; organic compound; unclassified drug; article; cycloaddition; drug activity; drug determination; drug structure; drug synthesis; spectroscopy; structure analysis |
Año: | 2007
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Volumen: | 37
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Número: | 23
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Página de inicio: | 4209
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Página de fin: | 4217
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DOI: |
http://dx.doi.org/10.1080/00397910701575178 |
Título revista: | Synthetic Communications
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Título revista abreviado: | Synth. Commun.
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ISSN: | 00397911
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CODEN: | SYNCA
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00397911_v37_n23_p4209_Fascio |
Referencias:
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Citas:
---------- APA ----------
Fascio, M.L., D'Accorso, N.B., Pellón, R.F. & Docampo, M.L.
(2007)
. Synthesis of novel carbohydrate acridinone derivatives with potential biological activities using 1,3-dipolar cycloaddition. Synthetic Communications, 37(23), 4209-4217.
http://dx.doi.org/10.1080/00397910701575178---------- CHICAGO ----------
Fascio, M.L., D'Accorso, N.B., Pellón, R.F., Docampo, M.L.
"Synthesis of novel carbohydrate acridinone derivatives with potential biological activities using 1,3-dipolar cycloaddition"
. Synthetic Communications 37, no. 23
(2007) : 4209-4217.
http://dx.doi.org/10.1080/00397910701575178---------- MLA ----------
Fascio, M.L., D'Accorso, N.B., Pellón, R.F., Docampo, M.L.
"Synthesis of novel carbohydrate acridinone derivatives with potential biological activities using 1,3-dipolar cycloaddition"
. Synthetic Communications, vol. 37, no. 23, 2007, pp. 4209-4217.
http://dx.doi.org/10.1080/00397910701575178---------- VANCOUVER ----------
Fascio, M.L., D'Accorso, N.B., Pellón, R.F., Docampo, M.L. Synthesis of novel carbohydrate acridinone derivatives with potential biological activities using 1,3-dipolar cycloaddition. Synth. Commun. 2007;37(23):4209-4217.
http://dx.doi.org/10.1080/00397910701575178