Artículo
García-Cordero, I.; Sedeño, L.; Fraiman, D.; Craiem, D.; De La Fuente, L.A.; Salamone, P.; Serrano, C.; Sposato, L.; Manes, F.; Ibañez, A. "Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula" (2015) Stroke. 46(9):2673-2677
Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor
Abstract:
Background and Purpose - Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods - Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results - Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions - Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications. © 2015 American Heart Association, Inc.
Registro:
| Documento: | Artículo |
| Título: | Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula |
| Autor: | García-Cordero, I.; Sedeño, L.; Fraiman, D.; Craiem, D.; De La Fuente, L.A.; Salamone, P.; Serrano, C.; Sposato, L.; Manes, F.; Ibañez, A. |
| Filiación: | Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University, Pacheco de Melo 1860, Buenos Aires, Argentina UDP-INECO Foundation Core on Neuroscience (UIFCoN), Faculty of Psychology, Diego Portales University, Santiago, Chile National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina Laboratorio de Investigación en Neurociencia, Universidad de San Andrés, Buenos Aires, Argentina Facultad de Ingeniería, Ciencias Exactas y Naturales, Universidad Favaloro, Buenos Aires, Argentina Memory and Balance Clinic, Buenos Aires, Argentina Department of Clinical Neurological Sciences, Western University, London, Canada Universidad Autónoma Del Caribe, Barranquilla, Colombia ACR Centre of Excellence in Cognition and Its Disorders, Sydney, Australia |
| Palabras clave: | cerebral cortex; dementia; magnetic resonance imaging; stroke; adult; aged; Article; cerebrospinal fluid; cerebrovascular accident; clinical article; controlled study; cuneus; female; frontal variant frontotemporal dementia; functional magnetic resonance imaging; gray matter; human; insula; intelligence quotient; male; nerve cell network; nerve degeneration; priority journal; salience network; stroke patient; voxel based morphometry; white matter; brain cortex; brain ischemia; cerebrovascular accident; connectome; frontotemporal dementia; middle aged; nuclear magnetic resonance imaging; pathophysiology; Aged; Brain Ischemia; Cerebral Cortex; Connectome; Female; Frontotemporal Dementia; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Stroke |
| Año: | 2015 |
| Volumen: | 46 |
| Número: | 9 |
| Página de inicio: | 2673 |
| Página de fin: | 2677 |
| DOI: | http://dx.doi.org/10.1161/STROKEAHA.115.009598 |
| Título revista: | Stroke |
| Título revista abreviado: | Stroke |
| ISSN: | 00392499 |
| CODEN: | SJCCA |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00392499_v46_n9_p2673_GarciaCordero |
Referencias:
- Van Den Heuvel, M.P., Sporns, O., Network hubs in the human brain (2013) Trends Cogn Sci., 17, pp. 683-696
- Craig, A.D., How do you feel-now? the anterior insula and human awareness (2009) Nat Rev Neurosci., 10, pp. 59-70
- Ibañez, A., Gleichgerrcht, E., Manes, F., Clinical effects of insular damage in humans (2010) Brain Struct Funct., 214, pp. 397-410
- Seeley, W.W., Crawford, R.K., Zhou, J., Miller, B.L., Greicius, M.D., Neurodegenerative diseases target large-scale human brain networks (2009) Neuron., 62, pp. 42-52
- Rascovsky, K., Hodges, J.R., Knopman, D., Mendez, M.F., Kramer, J.H., Neuhaus, J., Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia (2011) Brain., 134, pp. 2456-2477
- Baez, S., Couto, B., Torralva, T., Sposato, L.A., Huepe, D., Montañes, P., Comparing moral judgments of patients with frontotemporal dementia and frontal stroke (2014) JAMA Neurol., 71, pp. 1172-1176
- Grefkes, C., Fink, G.R., Connectivity-based approaches in stroke and recovery of function (2014) Lancet Neurol., 13, pp. 206-216
- Pievani, M., Filippini, N., Van Den Heuvel, M.P., Cappa, S.F., Frisoni, G.B., Brain connectivity in neurodegenerative diseases-from phenotype to proteinopathy (2014) Nat Rev Neurol., 10, pp. 620-633
- Day, G.S., Farb, N.A., Tang-Wai, D.F., Masellis, M., Black, S.E., Freedman, M., Salience network resting-state activity: Prediction of frontotemporal dementia progression (2013) JAMA Neurol., 70, pp. 1249-1253
- Pasquini, L., Scherr, M., Tahmasian, M., Meng, C., Myers, N.E., Ortner, M., Link between hippocampus' raised local and eased global intrinsic connectivity in AD (2015) Alzheimers Dement., 11, pp. 475-484
- Zang, Y., Jiang, T., Lu, Y., He, Y., Tian, L., Regional homogeneity approach to fMRI data analysis (2004) Neuroimage., 22, pp. 394-400
- Simmons, W.K., Avery, J.A., Barcalow, J.C., Bodurka, J., Drevets, W.C., Bellgowan, P., Keeping the body in mind: Insula functional organization and functional connectivity integrate interoceptive, exteroceptive, and emotional awareness (2013) Hum Brain Mapp., 34, pp. 2944-2958
- Carmichael, S.T., Plasticity of cortical projections after stroke (2003) Neuroscientist., 9, pp. 64-75
- Ibañez, A., Manes, F., Contextual social cognition and the behavioral variant of frontotemporal dementia (2012) Neurology., 78, pp. 1354-1362
- Crossley, N.A., Mechelli, A., Scott, J., Carletti, F., Fox, P.T., McGuire, P., The hubs of the human connectome are generally implicated in the anatomy of brain disorders (2014) Brain., 137, pp. 2382-2395
Citas:
---------- APA ----------
García-Cordero, I., Sedeño, L., Fraiman, D., Craiem, D., De La Fuente, L.A., Salamone, P., Serrano, C.,..., Ibañez, A. (2015) . Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula. Stroke, 46(9), 2673-2677.http://dx.doi.org/10.1161/STROKEAHA.115.009598
---------- CHICAGO ----------
García-Cordero, I., Sedeño, L., Fraiman, D., Craiem, D., De La Fuente, L.A., Salamone, P., et al. "Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula" . Stroke 46, no. 9 (2015) : 2673-2677.http://dx.doi.org/10.1161/STROKEAHA.115.009598
---------- MLA ----------
García-Cordero, I., Sedeño, L., Fraiman, D., Craiem, D., De La Fuente, L.A., Salamone, P., et al. "Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula" . Stroke, vol. 46, no. 9, 2015, pp. 2673-2677.http://dx.doi.org/10.1161/STROKEAHA.115.009598
---------- VANCOUVER ----------
García-Cordero, I., Sedeño, L., Fraiman, D., Craiem, D., De La Fuente, L.A., Salamone, P., et al. Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula. Stroke. 2015;46(9):2673-2677.http://dx.doi.org/10.1161/STROKEAHA.115.009598
