Abstract:
In this paper we report the synthesis of four fluorinated analogues of brassinosteroids in which fluorine was introduced stereoselectively at C-2. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that two of these analogues elicit high bioactivity, suggesting the involvement of hydrogen bond interactions between the active brassinosteroids and their cellular receptor. © 2008 Elsevier Inc. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Synthesis and biological activity of brassinosteroids fluorinated at C-2 |
Autor: | Acebedo, S.L.; Ramírez, J.A.; Galagovsky, L.R. |
Filiación: | Departamento de Quimica Organica and UMYMFOR (CONICET - Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellon 2, Piso 3, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina
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Palabras clave: | Brassinosteroids; Fluorinated steroids; Oryza sativa; 2alpha fluoro 3alpha,22,23 trihydroxy 5alpha stigmastan 6 one; 2alpha fluoro 3beta,22,23 trihydroxy 5alpha stigmastan 6 one; brassinosteroid; carbon; cell receptor; fluorinated steroid; hydrogen; unclassified drug; analytic method; article; biological activity; chemical bond; chemical interaction; chemical structure; fluorination; germination; hydrogen bond; nonhuman; plant growth; rice; seedling; stereochemistry; synthesis; Biological Assay; Cholestanols; Halogenation; Oryza sativa; Steroids, Heterocyclic; Oryza sativa |
Año: | 2009
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Volumen: | 74
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Número: | 4-5
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Página de inicio: | 435
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Página de fin: | 440
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DOI: |
http://dx.doi.org/10.1016/j.steroids.2008.12.006 |
Título revista: | Steroids
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Título revista abreviado: | Steroids
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ISSN: | 0039128X
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CODEN: | STEDA
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CAS: | carbon, 7440-44-0; hydrogen, 12385-13-6, 1333-74-0; Cholestanols; Steroids, Heterocyclic; brassinolide, 72962-43-7
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v74_n4-5_p435_Acebedo |
Referencias:
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Citas:
---------- APA ----------
Acebedo, S.L., Ramírez, J.A. & Galagovsky, L.R.
(2009)
. Synthesis and biological activity of brassinosteroids fluorinated at C-2. Steroids, 74(4-5), 435-440.
http://dx.doi.org/10.1016/j.steroids.2008.12.006---------- CHICAGO ----------
Acebedo, S.L., Ramírez, J.A., Galagovsky, L.R.
"Synthesis and biological activity of brassinosteroids fluorinated at C-2"
. Steroids 74, no. 4-5
(2009) : 435-440.
http://dx.doi.org/10.1016/j.steroids.2008.12.006---------- MLA ----------
Acebedo, S.L., Ramírez, J.A., Galagovsky, L.R.
"Synthesis and biological activity of brassinosteroids fluorinated at C-2"
. Steroids, vol. 74, no. 4-5, 2009, pp. 435-440.
http://dx.doi.org/10.1016/j.steroids.2008.12.006---------- VANCOUVER ----------
Acebedo, S.L., Ramírez, J.A., Galagovsky, L.R. Synthesis and biological activity of brassinosteroids fluorinated at C-2. Steroids. 2009;74(4-5):435-440.
http://dx.doi.org/10.1016/j.steroids.2008.12.006