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Abstract:

In the present paper, we report that an inositolphosphoglycan (IPG), derived from a Trypanosoma cruzi glycoinositolphosphoceramide (LPPG), is able to inhibit ACTH-mediated accumulation of a glucocorticoid, cortisol, in calf adrenocortical cells. This IPG is also able to inhibit the stimulation by ACTH of the production of the main glucocorticoid, corticosterone and the main mineralocorticoid, aldosterone, in rat adrenocortical cells. Nitrous acid deamination confirmed that IPG is responsible for this inhibition. In order to study the involvement of glycosylphosphatidylinositol (GPI) in ACTH response in rat adrenal cortex, the activation of a phospholipase that hydrolyzes GPI (GPI-PLC) was evaluated. It was found that the release of alkaline phosphatase, a GPI-anchored enzyme, to the extracellular medium is increased in rat adrenocortical cells by ACTH treatment. In addition, ACTH stimulates the release of ceramide from the glycoinositolphosphoceramide purified from T. cruzi. These data suggest that ACTH activates a GPI-PLC in rat adrenal cortex, which is in agreement with our previous data in calf adrenocortical cells; thus, the hydrolysis of GPI provoked by ACTH takes place in different mammals and the IPG released could inhibit ACTH-mediated synthesis of aldosterone, corticosterone and cortisol.

Registro:

Documento: Artículo
Título:ACTH-mediated glucocorticoid and mineralocorticoid production is inhibited by an inositolphosphoglycan and a glycosylphosphatidylinositol- phospholipase C is activated by the hormone in mammalian adrenocortical cells
Autor:De Avalos, S.V.; Lima, C.; Martini, C.; De Lederkremer, R.M.; Vila, M.D.C.
Filiación:Depto. de Quimica Biológica, Fac. de Cie. Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Depto. de Quimica Orgánica, Fac. de Cie. Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:ACTH; Aldosterone; Corticostero ne; Cortisol; Glycosylphosphatidylinositol; Inositolphosphoglycan; corticotropin; glucocorticoid; glycosylphosphatidylinositol; mineralocorticoid; phospholipase c; adrenal cortex; aldosterone release; animal cell; article; cattle; enzyme activation; hydrocortisone release; nonhuman; trypanosoma cruzi; Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Animals; Cattle; Corticosterone; Enzyme Activation; Glucocorticoids; Glycolipids; Hydrocortisone; Inositol Phosphates; Male; Mineralocorticoids; Oligosaccharides; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase C; Polysaccharides; Rats; Rats, Sprague-Dawley; Trypanosoma cruzi
Año:1998
Volumen:63
Número:2
Página de inicio:70
Página de fin:75
DOI: http://dx.doi.org/10.1016/S0039-128X(97)00137-2
Título revista:Steroids
Título revista abreviado:Steroids
ISSN:0039128X
CODEN:STEDA
CAS:Adrenocorticotropic Hormone, 9002-60-2; Aldosterone, 52-39-1; Corticosterone, 50-22-6; Glucocorticoids; Glycolipids; Hydrocortisone, 50-23-7; inositol phosphate glycan; Inositol Phosphates; LPPG glycoinositolphosphoceramide; Mineralocorticoids; Oligosaccharides; Phosphatidylinositol Diacylglycerol-Lyase, EC 4.6.1.13; Phospholipase C, EC 3.1.4.3; Polysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v63_n2_p70_DeAvalos

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Citas:

---------- APA ----------
De Avalos, S.V., Lima, C., Martini, C., De Lederkremer, R.M. & Vila, M.D.C. (1998) . ACTH-mediated glucocorticoid and mineralocorticoid production is inhibited by an inositolphosphoglycan and a glycosylphosphatidylinositol- phospholipase C is activated by the hormone in mammalian adrenocortical cells. Steroids, 63(2), 70-75.
http://dx.doi.org/10.1016/S0039-128X(97)00137-2
---------- CHICAGO ----------
De Avalos, S.V., Lima, C., Martini, C., De Lederkremer, R.M., Vila, M.D.C. "ACTH-mediated glucocorticoid and mineralocorticoid production is inhibited by an inositolphosphoglycan and a glycosylphosphatidylinositol- phospholipase C is activated by the hormone in mammalian adrenocortical cells" . Steroids 63, no. 2 (1998) : 70-75.
http://dx.doi.org/10.1016/S0039-128X(97)00137-2
---------- MLA ----------
De Avalos, S.V., Lima, C., Martini, C., De Lederkremer, R.M., Vila, M.D.C. "ACTH-mediated glucocorticoid and mineralocorticoid production is inhibited by an inositolphosphoglycan and a glycosylphosphatidylinositol- phospholipase C is activated by the hormone in mammalian adrenocortical cells" . Steroids, vol. 63, no. 2, 1998, pp. 70-75.
http://dx.doi.org/10.1016/S0039-128X(97)00137-2
---------- VANCOUVER ----------
De Avalos, S.V., Lima, C., Martini, C., De Lederkremer, R.M., Vila, M.D.C. ACTH-mediated glucocorticoid and mineralocorticoid production is inhibited by an inositolphosphoglycan and a glycosylphosphatidylinositol- phospholipase C is activated by the hormone in mammalian adrenocortical cells. Steroids. 1998;63(2):70-75.
http://dx.doi.org/10.1016/S0039-128X(97)00137-2