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Abstract:

The effect of endothelin-1 (ET-1) on cholesterol uptake by adrenal cortex was evaluated through several experimental approaches: infusion of ET-1 followed by measurement of endogenous cholesterol in excised adrenals; infusion of ET-1 followed by tritiated cholesterol incorporation into adrenal quarters in vitro; coinfusion of ET-1 with tritiated cholesterol-enriched serum and determination of adrenal-associated radioactivity; and tritiated cholesterol incorporation in incubations of adrenal cells. In all cases ET-1 increased cholesterol uptake. Subcellular fractionation showed an ET-1-mediated augmentation in mitochondrial fraction. This increase was mediated by the subpopulation B of adrenal receptors for ET-1. In addition, ET-1 also increased cytochrome P450-SCC (side-chain cleavage) activity. © 1996 by Elsevier Science Inc.

Registro:

Documento: Artículo
Título:Endothelin-1 -induced incorporation of cholesterol into rat adrenals
Autor:Romero, D.G.; Pecci, A.; Lantos, C.P.; Cozza, E.N.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and PRHOM-CONICET, Buenos Aires, Argentina
Departamento de Química Biologica, Facultad de Cs. Exactas y Naturales - UBA, Ciudad Universitaria, Pab 2, Piso 4, 1428-Buenos Aires, Argentina
Palabras clave:Adrenal; Cholesterol; Endothelin; Steroidogenesis; 3(or 17)beta hydroxysteroid dehydrogenase; aminoglutethimide; cholesterol; cholesterol monooxygenase (side chain cleaving); endothelin 1; endothelin receptor; isomerase; tritium; adrenal cell; adrenal cortex; animal cell; animal experiment; animal tissue; article; cell culture; cell fractionation; cholesterol metabolism; cholesterol transport; controlled study; enzyme activity; infusion; isotope labeling; male; nonhuman; radioactivity; rat; Adrenal Glands; Aldosterone; Aminoglutethimide; Animals; Cholesterol; Endothelin-1; Infusions, Intravenous; Male; Rats; Rats, Inbred Strains; Animalia; Tritium
Año:1996
Volumen:61
Número:5
Página de inicio:317
Página de fin:322
DOI: http://dx.doi.org/10.1016/0039-128X(96)00003-7
Título revista:Steroids
Título revista abreviado:Steroids
ISSN:0039128X
CODEN:STEDA
CAS:Aldosterone, 52-39-1; Aminoglutethimide, 125-84-8; Cholesterol, 57-88-5; Endothelin-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v61_n5_p317_Romero

Referencias:

  • Yanasigawa, M., Kurihara, H., Kimura, S., Kobayashi M, T.Y., Mitsui, Y., Yazaki, Y., Goto, K., Masaki, T., A novel potent vasoconstrictor peptide produced by vascular endothelial cells (1988) Nature, 232, pp. 411-415
  • Inoue, A., Yanasigawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K., Masaki, T., The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes (1989) Proc Natl Acad Sci USA, 86, pp. 2863-2867
  • Yanasigawa, M., Inoue, A., Ishikawa, T., Kasuya, Y., Kimura, S., Kumagaye, S.I., Nakajima, K., Masaki, T., Primary structure, synthesis and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide (1988) Proc Natl Acad Sci USA, 85, pp. 6964-6967
  • Kloog, Y., Ambar, I., Sokolovsky, M., Kochva, E., Wollberg, Z., Sarafotoxin, a novel vasoconstrictor peptide: Phosphoinositide hydrolysis in rat heart and brain (1988) Science, 242, pp. 268-270
  • Ambar, I., Kloog, Y., Kochva, E., Wollberg, Z., Bdolah, A., Oron, U., Sokolovsky, M., Characterization and localization of a novel neuroreceptor for the peptide sarafotoxin (1988) Biochem Biophys Res Commun, 157, pp. 1104-1110
  • Cozza, E.N., Gomez-Sanchez, C.E., Effects of endothelin-1 on its receptor concentration and thymidine incorporation in calf adrenal zone glomerulosa cells: A comparative study with phorbol esters (1990) Endocrinology, 127, pp. 549-554
  • Davenport, A.P., Nunez, D.J., Hall, J.A., Kaumann, A.J., Brown, M.J., Autoradiographical localization of binding sites for porcine [125I]-endothelin-1 in humans, pigs and rats: Functional relevance in humans (1989) J Cardiovasc Pharmacol, 13, pp. 5166-5170
  • Cozza, E.N., Gomez-Sanchez, C.E., Foecking, M.F., Chiou, S., Endothelin binding to cultured calf adrenal zona glomerulosa cells and stimulation of aldosterone secretion (1989) J Clin Invest, 84, pp. 1032-1035
  • Morishita, R., Higaki, J., Ogihara, T., Endothelin stimulates aldosterone biosynthesis by dispersed rabbit adreno-capsular cells (1989) Biochem Biophys Res Commun, 160, pp. 628-632
  • Hinson, J.P., Vinson, G.P., Kapas, S., Teja, R., The role of endothelin in the control of adrenocortical function: Stimulation of endothelin release by ACTH and the effects of endothelin-1 and endothelin-3 on steroidogenesis in rat and human adrenocortical cells (1991) J Endocrinol, 128, pp. 275-280
  • Mazzocchi, G., Rebuffat, P., Meneghelli, V., Malendowicz, L., Kasprzak, A., Nussdorfer, G.G., Effects of prolonged infusion with endothelin-1 on the function and morphology of rat adrenal cortex (1991) Peptides, 11, pp. 767-772
  • Mazzocchi, G., Malendowicz, L., Nussdorfer, G.G., Endothelin-1 acutely stimulates the secretory activity of rat zona glomerulosa cells (1991) Peptides, 11, pp. 763-765
  • Cozza, E.N., Chiou, S., Gomez-Sanchez, C.E., Endothelin-1 potentiation of angiotensin II stimulation of aldosterone secretion (1992) Am J Physiol, 262, pp. R85-R89
  • Cozza, E.N., Gomez-Sanchez, C.E., Mechanism of the ET-1 potentiation of angiotensin II stimulation of aldosterone production in calf adrenal glomerulosa cell cultures (1993) Am J Physiol, 265, pp. E179-E183
  • Rosolowsky, L.J., Campbell, W.B., Endothelin enhances adrenocorticotropin-stimulated aldosterone release from cultured bovine adrenal cells (1990) Endocrinology, 126, pp. 1860-1866

Citas:

---------- APA ----------
Romero, D.G., Pecci, A., Lantos, C.P. & Cozza, E.N. (1996) . Endothelin-1 -induced incorporation of cholesterol into rat adrenals. Steroids, 61(5), 317-322.
http://dx.doi.org/10.1016/0039-128X(96)00003-7
---------- CHICAGO ----------
Romero, D.G., Pecci, A., Lantos, C.P., Cozza, E.N. "Endothelin-1 -induced incorporation of cholesterol into rat adrenals" . Steroids 61, no. 5 (1996) : 317-322.
http://dx.doi.org/10.1016/0039-128X(96)00003-7
---------- MLA ----------
Romero, D.G., Pecci, A., Lantos, C.P., Cozza, E.N. "Endothelin-1 -induced incorporation of cholesterol into rat adrenals" . Steroids, vol. 61, no. 5, 1996, pp. 317-322.
http://dx.doi.org/10.1016/0039-128X(96)00003-7
---------- VANCOUVER ----------
Romero, D.G., Pecci, A., Lantos, C.P., Cozza, E.N. Endothelin-1 -induced incorporation of cholesterol into rat adrenals. Steroids. 1996;61(5):317-322.
http://dx.doi.org/10.1016/0039-128X(96)00003-7