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Abstract:

Aldosterone production from 11-deoxycorticosterone was stimulated by hemin in primary cultures and homogenates of calf adrenal zona glomerulosa, in a time- and dose-dependent fashion. The ferrochelatase inhibitor 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) blocked the stimulation of aldosterone mediated by adrenocorticotropin (ACTH). Addition of hemin after treatment with DDC partially restored ACTH action. These results suggest that hemin may play a role in regulation of aldosterone production. © 1993.

Registro:

Documento: Artículo
Título:Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
Autor:Cozza, E.N.; Vila, M.d.C.; Gomez-Sanchez, C.E.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Department of Internal Medicine, College of Medicine, University of South Florida, Tampa, FL, United States
Palabras clave:aldosterone stimulation, hemin; hemin, aldosterone stimulation; 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester; aldosterone; corticotropin; cytochrome p450; hemin; adrenal cell; aldosterone release; animal cell; cattle; cell culture; conference paper; controlled study; dose time effect relation; enzyme activity; incubation time; liver metabolism; metabolic regulation; nonhuman; steroidogenesis; zona glomerulosa; Aldosterone; Animal; Cattle; Cells, Cultured; Corticotropin; Dicarbethoxydihydrocollidine; Female; Ferrochelatase; Hemin; Kinetics; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Zona Glomerulosa; Animalia; Bos taurus
Año:1993
Volumen:58
Número:8
Página de inicio:384
Página de fin:386
DOI: http://dx.doi.org/10.1016/0039-128X(93)90042-L
Título revista:Steroids
Título revista abreviado:Steroids
ISSN:0039128X
CODEN:STEDA
CAS:Aldosterone, 52-39-1; Corticotropin, 9002-60-2; Dicarbethoxydihydrocollidine, 632-93-9; Ferrochelatase, EC 4.99.1.1; Hemin, 16009-13-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v58_n8_p384_Cozza

Referencias:

  • Hall, Steroidogenic cytochromes P450: do the properties of the homogeneous enzymes reveal important aspects of the regulation of steroid synthesis in vivo (1984) Endocr Res., 10, pp. 311-317
  • Nonaka, Okamoto, Morohashi, Kirita, Hashimoto, Omura, Functional expression of cDNAs for bovine 11β-hydroxylase-aldosterone synthases P450(11β)-2 and -3 and their chimeras (1992) The Journal of Steroid Biochemistry and Molecular Biology, 41, pp. 79-780
  • Watanuki, Tilley, Hall, Cytochrome P-450 for 11β and 18-hydroxylase activities of bovine adrenocortical mitochondria: one enzyme or two (1978) Biochemistry, 17, pp. 127-130
  • Ogishima, Mitani, Ishimura, Isolation of two distinct cytochromes P-450 11β with aldosterone synthase activity from bovine adrenocortical mitochondria (1989) J Biochem, 105, pp. 497-499
  • Ogishima, Mitani, Ishimura, Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex (1989) J Biol Chem, 264, pp. 10935-10938
  • Bellino, Hussa, Estrogen synthetase stimulation by hemin in human carcinoma cell cultures (1985) Biochem Biophys Res Commun, 127, pp. 232-238
  • Pikuleva, Lapko, Chashchin, Functional reconstitution of cytochrome P-450scc with hemin activated with Woodward's Reagent K (1992) J Biol Chem, 267, pp. 1438-1442
  • Cozza, Gomez-Sanchez, Foecking, Chiou, Endothelin binding to cultured calf adrenal zona glomerulosa cells and stimulation of aldosterone secretion (1989) J. Clin Invest, 84, pp. 1032-1035
  • Cozza, Vila, Acevedo-Duncan, Farese, Gomez-Sanchez, Treatment of primary cultures of calf adrenal glomerulosa cells with ACTH and phorbol esters. A comparative study of the effects on aldosterone production and on ACTH signalling system (1990) Endocrinology, 126, pp. 2169-2176
  • Cozza, Foecking, Gomez-Sanchez, The binding of cortisol to adrenal mitochondria (1990) J Steroid Biochem, 35, pp. 511-514
  • Gomez-Sanchez, Foecking, Ferris, Chavarri, Uribe, Gomez-Sanchez, The production of monoclonal antibodies against aldosterone (1987) Steroids, 49, pp. 581-587
  • Cole, Marks, Ferrochelatase and N-alkylated porphyrins (1984) Mol Cell Biochem, 64, pp. 127-137
  • Marks, McCluskey, Mackie, Riddick, James, Disruption of hepatic heme biosynthesis after interactions of xenobiotics with cytochrome P450 (1988) FASEB J, 2, pp. 2774-2783

Citas:

---------- APA ----------
Cozza, E.N., Vila, M.d.C. & Gomez-Sanchez, C.E. (1993) . Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures. Steroids, 58(8), 384-386.
http://dx.doi.org/10.1016/0039-128X(93)90042-L
---------- CHICAGO ----------
Cozza, E.N., Vila, M.d.C., Gomez-Sanchez, C.E. "Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures" . Steroids 58, no. 8 (1993) : 384-386.
http://dx.doi.org/10.1016/0039-128X(93)90042-L
---------- MLA ----------
Cozza, E.N., Vila, M.d.C., Gomez-Sanchez, C.E. "Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures" . Steroids, vol. 58, no. 8, 1993, pp. 384-386.
http://dx.doi.org/10.1016/0039-128X(93)90042-L
---------- VANCOUVER ----------
Cozza, E.N., Vila, M.d.C., Gomez-Sanchez, C.E. Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures. Steroids. 1993;58(8):384-386.
http://dx.doi.org/10.1016/0039-128X(93)90042-L