Artículo

Sorianello, E.; Schillaci, R.; Chamson-Reig, A.; Lux-Lantos, V.; Libertun, C. "Actions of immunosuppressor drugs on the development of an experimental ovarian tumor" (2002) Experimental Biology and Medicine. 227(8):658-664
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Abstract:

Immunosuppression has been related to the incidence of tumor apparition, including endocrine tumors. The intrasplenic ovarian tumor (luteoma) is a typical benign endocrine tumor that develops under high gonadotropin stimulation and, from the immunological perspective, is located in a critical organ involved in immune response. To establish if immunosuppression could alter the development of this experimental tumor, the effects of cyclosporin A (CsA) and dexamethasone (Dex) were evaluated. After surgery, tumor-bearing and sham animals were kept without treatment for 4 weeks; thereafter, they were distributed into CsA (25 mg/kg), Dex (0.1 mg/kg), or vehicle (75:25 castor oil:ethanol) groups and were injected on alternate days for 50 days. Body weight was evaluated weekly. Animals were sacrificed after a jugular vein blood sample was obtained. Thyml were weighed. Tumors were measured and placed in formaline for histological studies. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), and estradiol were measured by radioimmunoassay. Hematological parameters were determined. CsA induced a significant decrease in survival rates both in tumor-bearing and sham animals (P < 0.01). Dex significantly impaired weight increase in both groups of animals. CsA induced a significant weight loss in sham animals, not observed in tumor-bearing animals. Dex induced thymus weight loss in both groups, whereas CsA induced thymus weight loss only in sham animals. Only Dex induced a decrease in lymphocyte number in both groups. CsA induced an increase in monocyte number only in sham animals. Treatments did not alter LH, FSH, or estradiol, whereas PRL was increased by CsA only in sham rats. Neither Dex nor CsA induced any significant variations in tumor volume, nor did they alter tumor histology. In addition, no visible metastases or alterations in other organs were observed. We conclude that, though immunological parameters were altered by the treatments, immunosuppressor drugs did not condition tumor development. In addition, tumors secrete one or more factor/s that counteract CsA effect.

Registro:

Documento: Artículo
Título:Actions of immunosuppressor drugs on the development of an experimental ovarian tumor
Autor:Sorianello, E.; Schillaci, R.; Chamson-Reig, A.; Lux-Lantos, V.; Libertun, C.
Filiación:Inst. de Biol. y Med. Exp.-Consejo Nacional de Investigaciones Cientificas y Tecnicas, Facultad de Medicina, Universidad de Buenos Aires, (1428) Buenos Aires, Argentina
Departmento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Vuelta de Obligado 2490, (1428) Buenos Aires, Argentina
Palabras clave:Cyclosporin A; Dexamethasone; Immunosuppression; Luteoma; cyclosporin A; dexamethasone; estradiol; follitropin; immunosuppressive agent; luteinizing hormone; prolactin; animal experiment; animal model; animal tissue; article; cancer growth; cancer risk; chemical carcinogenesis; controlled study; experimental neoplasm; female; histopathology; immunosuppressive treatment; luteoma; mouse; nonhuman; Animals; Body Weight; Cyclosporine; Dexamethasone; Estradiol; Female; Follicle Stimulating Hormone; Immunocompromised Host; Immunosuppressive Agents; Luteinizing Hormone; Luteoma; Neoplasm Transplantation; Organ Size; Ovarian Neoplasms; Ovariectomy; Ovary; Prolactin; Rats; Rats, Sprague-Dawley; Spleen; Thymus Gland; Transplantation, Heterotopic; Animalia; Castor
Año:2002
Volumen:227
Número:8
Página de inicio:658
Página de fin:664
Título revista:Experimental Biology and Medicine
Título revista abreviado:Exp. Biol. Med.
ISSN:00379727
CODEN:EBMMB
CAS:Cyclosporine, 59865-13-3; Dexamethasone, 50-02-2; Estradiol, 50-28-2; Follicle Stimulating Hormone, 9002-68-0; Immunosuppressive Agents; Luteinizing Hormone, 9002-67-9; Prolactin, 9002-62-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v227_n8_p658_Sorianello

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Citas:

---------- APA ----------
Sorianello, E., Schillaci, R., Chamson-Reig, A., Lux-Lantos, V. & Libertun, C. (2002) . Actions of immunosuppressor drugs on the development of an experimental ovarian tumor. Experimental Biology and Medicine, 227(8), 658-664.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v227_n8_p658_Sorianello [ ]
---------- CHICAGO ----------
Sorianello, E., Schillaci, R., Chamson-Reig, A., Lux-Lantos, V., Libertun, C. "Actions of immunosuppressor drugs on the development of an experimental ovarian tumor" . Experimental Biology and Medicine 227, no. 8 (2002) : 658-664.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v227_n8_p658_Sorianello [ ]
---------- MLA ----------
Sorianello, E., Schillaci, R., Chamson-Reig, A., Lux-Lantos, V., Libertun, C. "Actions of immunosuppressor drugs on the development of an experimental ovarian tumor" . Experimental Biology and Medicine, vol. 227, no. 8, 2002, pp. 658-664.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v227_n8_p658_Sorianello [ ]
---------- VANCOUVER ----------
Sorianello, E., Schillaci, R., Chamson-Reig, A., Lux-Lantos, V., Libertun, C. Actions of immunosuppressor drugs on the development of an experimental ovarian tumor. Exp. Biol. Med. 2002;227(8):658-664.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v227_n8_p658_Sorianello [ ]