Artículo

Lux-Lantos, V.; Somoza, G.; Rey, E.; Libertun, C. "Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor" (1991) Proceedings of the Society for Experimental Biology and Medicine. 197(3):337-341
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Abstract:

The mechanism of action of a specific γ-aminobutyric acid B receptor agonist, γ-p-chlorophenyl-γ-aminobutyric acid or baclofen, in its inhibitory action on prolactin release, was studied. Dose-response studies of the effect of baclofen on prolactin (PRL) secretion were performed in stressed male rats. Furthermore, the action of the drug was evaluated in (i) rats treated with haloperidol or α-methyl-p-tyrosine, (ii) stressed or suckled rats pretreated with sulpiride, and (iii) animals treated with serotonin, alone, or with α-methyl-p-tyrosine. Baclofen showed a clear dose-dependent inhibition of prolactin secretion in males under stress. The drug was unable to inhibit the prolactin release induced by haloperidol or α-methyl-p-tyrosine, although it reduced the PRL secretion induced by serotonin. It also inhibited PRL release in sulpiride-pretreated stressed or suckled rats. These results suggest that the dose-dependent effect of baclofen on PRL secretion is the consequence of an inhibition exerted on the prolactin-releasing factor component of the neuroendocrine responses evoked by stress or suckling, possibly acting at the serotonergic system. © 1991, SAGE Publications. All rights reserved.

Registro:

Documento: Artículo
Título:Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor
Autor:Lux-Lantos, V.; Somoza, G.; Rey, E.; Libertun, C.
Filiación:Laboratorio de Neuroendocrinologia, Instituto de Biologia y Medicina Experimental, V. Obligado 2490, (1428) Buenos Aires, Argentina
Palabras clave:baclofen; haloperidol; metirosine; prolactin releasing factor; serotonin; sulpiride; animal experiment; article; controlled study; female; intraperitoneal drug administration; male; priority journal; prolactin release; rat; alpha-Methyltyrosine; Animal; Baclofen; Dose-Response Relationship, Drug; Female; Haloperidol; Male; Methyltyrosines; Prolactin; Prolactin-Releasing Hormone; Rats; Rats, Inbred Strains; Serotonin; Sulpiride; Support, Non-U.S. Gov't
Año:1991
Volumen:197
Número:3
Página de inicio:337
Página de fin:341
DOI: http://dx.doi.org/10.3181/00379727-197-43265
Título revista:Proceedings of the Society for Experimental Biology and Medicine
Título revista abreviado:Proc. Soc. Exp. Biol. Med.
ISSN:00379727
CAS:alpha-Methyltyrosine, 658-48-0; Baclofen, 1134-47-0; Haloperidol, 52-86-8; Methyltyrosines; Prolactin, 9002-62-4; Prolactin-Releasing Hormone; Serotonin, 50-67-9; Sulpiride, 15676-16-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v197_n3_p337_LuxLantos

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Citas:

---------- APA ----------
Lux-Lantos, V., Somoza, G., Rey, E. & Libertun, C. (1991) . Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor. Proceedings of the Society for Experimental Biology and Medicine, 197(3), 337-341.
http://dx.doi.org/10.3181/00379727-197-43265
---------- CHICAGO ----------
Lux-Lantos, V., Somoza, G., Rey, E., Libertun, C. "Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor" . Proceedings of the Society for Experimental Biology and Medicine 197, no. 3 (1991) : 337-341.
http://dx.doi.org/10.3181/00379727-197-43265
---------- MLA ----------
Lux-Lantos, V., Somoza, G., Rey, E., Libertun, C. "Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor" . Proceedings of the Society for Experimental Biology and Medicine, vol. 197, no. 3, 1991, pp. 337-341.
http://dx.doi.org/10.3181/00379727-197-43265
---------- VANCOUVER ----------
Lux-Lantos, V., Somoza, G., Rey, E., Libertun, C. Further Evidence for the Inhibitory Action of Baclofen on a Prolactin-Releasing Factor. Proc. Soc. Exp. Biol. Med. 1991;197(3):337-341.
http://dx.doi.org/10.3181/00379727-197-43265