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Abstract:

The presence and the importance of a preovulatory prolactin (PRL) peak was determined in four, natural or artificially induced, ovulatory models related to lactation in the rat. Gonadotrophin peaks were determined in the afternoon preceding ovulation in four models: postpartum ovulation (PPO), ovulation after the lactational period (AL) (natural models), ovulation after litter removal at midlactation (ML), and ovulation in lactating rats (LR) (artificially induced models). In PPO, AL, and ML rats a preovulatory PRL surge was detected, showing that its presence is a common characteristic of ovulation in the rat. Bromocriptine inhibition of PRL levels in PPO and AL rats did not modify the percentage of rats which ovulated. In contrast, this treatment was able to significantly increase ovulation percentage in ML rats. Moreover, in LR rats strong dopaminergic inhibition of PRL levels, induced by pergolide, was necessary for ovulation to take place, but if pergolide-treated rats were injected with ovine PRL ovulation was completely inhibited. These data suggest that while a PRL surge seems to be always present in natural ovulatory models, it is not essential for ovulation to take place. On the other hand, in artificially induced ovulatory models, suppression of prolactinemia is able to induce ovulation or to increase the percentage of rats which ovulated. This effect of PRL on ovulation may be direct or indirect. © 1988, SAGE Publications. All rights reserved.

Registro:

Documento: Artículo
Título:Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin
Autor:Lux, V.A.R.; Ramírez, M.I.; Libertun, C.
Filiación:Laboratorio de Neuroendocrinología, Instituto de Biología y Medicina Experimental, 1428 Buenos Aires, Argentina
Palabras clave:bromocriptine; follitropin; luteinizing hormone; pergolide; prolactin; prolactin; animal; article; biological model; blood; drug effect; female; lactation; ovulation; ovulation induction; physiology; pregnancy; puerperium; rat; rat strain; estrus cycle; lactation; nonhuman; Animal; Bromocriptine; Female; Follicle Stimulating Hormone; Lactation; Luteinizing Hormone; Models, Biological; Ovulation; Ovulation Induction; Pergolide; Pregnancy; Prolactin; Puerperium; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't
Año:1988
Volumen:188
Número:3
Página de inicio:301
Página de fin:307
DOI: http://dx.doi.org/10.3181/00379727-188-42738
Título revista:Proceedings of the Society for Experimental Biology and Medicine
Título revista abreviado:Proc. Soc. Exp. Biol. Med.
ISSN:00379727
CAS:bromocriptine, 25614-03-3; follitropin, 9002-68-0; luteinizing hormone, 39341-83-8, 9002-67-9; pergolide, 66104-22-1; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; Bromocriptine, 25614-03-3; Follicle Stimulating Hormone, 9002-68-0; Luteinizing Hormone, 9002-67-9; Pergolide, 66104-22-1; Prolactin, 9002-62-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v188_n3_p301_Lux

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Citas:

---------- APA ----------
Lux, V.A.R., Ramírez, M.I. & Libertun, C. (1988) . Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin. Proceedings of the Society for Experimental Biology and Medicine, 188(3), 301-307.
http://dx.doi.org/10.3181/00379727-188-42738
---------- CHICAGO ----------
Lux, V.A.R., Ramírez, M.I., Libertun, C. "Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin" . Proceedings of the Society for Experimental Biology and Medicine 188, no. 3 (1988) : 301-307.
http://dx.doi.org/10.3181/00379727-188-42738
---------- MLA ----------
Lux, V.A.R., Ramírez, M.I., Libertun, C. "Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin" . Proceedings of the Society for Experimental Biology and Medicine, vol. 188, no. 3, 1988, pp. 301-307.
http://dx.doi.org/10.3181/00379727-188-42738
---------- VANCOUVER ----------
Lux, V.A.R., Ramírez, M.I., Libertun, C. Natural and Artificially Induced Ovulatory Models Related to Lactation in the Rat: Role of Prolactin. Proc. Soc. Exp. Biol. Med. 1988;188(3):301-307.
http://dx.doi.org/10.3181/00379727-188-42738