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Abstract:

Baclofen, a GABA B agonist, inhibits prolactin release due to different kinds of stress. In the present study its effect was evaluated in several endocrine experimental situations to explore the specificity of this effect, as well as the site of action of the drug. Baclofen significantly inhibited prolactin and thyrotropin outputs induced by 25 min of suckling, without altering milk ejection or LH secretion. The effect was also tested in median eminence-lesioned rats and in in vitro incubations. Baclofen did not modify prolactin levels in rats in which brain control of the pituitary secretion was eliminated by destruction of the median eminence, and it did not inhibit prolactin or thyrotropin secretion from incubated hemipituitaries. It is postulated that baclofen inhibits prolactin and thyrotropin secretion by acting on GABA B receptors related to the brain control of pituitary secretion. © 1986, SAGE Publications. All rights reserved.

Registro:

Documento: Artículo
Título:ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain
Autor:Lux, V.A.R.; Somoza, G.M.; Libertun, C.
Filiación:Instituto de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:4 aminobutyric acid b receptor; 4 aminobutyric acid receptor; baclofen; dopamine; prolactin; thyrotropin; animal experiment; brain; central nervous system; drug mechanism; drug monitoring; drug receptor binding; endocrine system; hormone release; hypophysis; intraperitoneal drug administration; median eminence; nonhuman; preliminary communication; priority journal; rat; Animal; Animals, Suckling; Baclofen; Brain; Female; Luteinizing Hormone; Male; Median Eminence; Physical Stimulation; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Thyrotropin
Año:1986
Volumen:183
Número:3
Página de inicio:358
Página de fin:362
DOI: http://dx.doi.org/10.3181/00379727-183-42431
Título revista:Proceedings of the Society for Experimental Biology and Medicine
Título revista abreviado:Proc. Soc. Exp. Biol. Med.
ISSN:00379727
CAS:baclofen, 1134-47-0; dopamine, 51-61-6, 62-31-7; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; thyrotropin, 9002-71-5; Baclofen, 1134-47-0; Luteinizing Hormone, 9002-67-9; Prolactin, 9002-62-4; Thyrotropin, 9002-71-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v183_n3_p358_Lux

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Citas:

---------- APA ----------
Lux, V.A.R., Somoza, G.M. & Libertun, C. (1986) . ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain. Proceedings of the Society for Experimental Biology and Medicine, 183(3), 358-362.
http://dx.doi.org/10.3181/00379727-183-42431
---------- CHICAGO ----------
Lux, V.A.R., Somoza, G.M., Libertun, C. "ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain" . Proceedings of the Society for Experimental Biology and Medicine 183, no. 3 (1986) : 358-362.
http://dx.doi.org/10.3181/00379727-183-42431
---------- MLA ----------
Lux, V.A.R., Somoza, G.M., Libertun, C. "ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain" . Proceedings of the Society for Experimental Biology and Medicine, vol. 183, no. 3, 1986, pp. 358-362.
http://dx.doi.org/10.3181/00379727-183-42431
---------- VANCOUVER ----------
Lux, V.A.R., Somoza, G.M., Libertun, C. ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain. Proc. Soc. Exp. Biol. Med. 1986;183(3):358-362.
http://dx.doi.org/10.3181/00379727-183-42431