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Petrillo, E.; Godoy Herz, M.A.; Fuchs, A.; Reifer, D.; Fuller, J.; Yanovsky, M.J.; Simpson, C.; Brown, J.W.S.; Barta, A.; Kalyna, M.; Kornblihtt, A.R. "A chloroplast retrograde signal regulates nuclear alternative splicing" (2014) Science. 344(6182):427-430
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Abstract:

Light is a source of energy and also a regulator of plant physiological adaptations. We show here that light/dark conditions affect alternative splicing of a subset of Arabidopsis genes preferentially encoding proteins involved in RNA processing. The effect requires functional chloroplasts and is also observed in roots when the communication with the photosynthetic tissues is not interrupted, suggesting that a signaling molecule travels through the plant. Using photosynthetic electron transfer inhibitors with different mechanisms of action, we deduce that the reduced pool of plastoquinones initiates a chloroplast retrograde signaling that regulates nuclear alternative splicing and is necessary for proper plant responses to varying light conditions.

Registro:

Documento: Artículo
Título:A chloroplast retrograde signal regulates nuclear alternative splicing
Autor:Petrillo, E.; Godoy Herz, M.A.; Fuchs, A.; Reifer, D.; Fuller, J.; Yanovsky, M.J.; Simpson, C.; Brown, J.W.S.; Barta, A.; Kalyna, M.; Kornblihtt, A.R.
Filiación:Laboratorio de Fisiología Y Biología Molecular, Departamento de Fisiología, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
Max F. Perutz Laboratories, Medical University of Vienna, A-1030 Vienna, Austria
Cell and Molecular Sciences, James Hutton Institute, Invergowrie, Dundee, United Kingdom
Fundación Instituto Leloir, IIBBA-CONICET, C1405BWE Buenos Aires, Argentina
Division of Plant Sciences, University of Dundee, James Hutton Institute, Invergowrie, Dundee, United Kingdom
Department of Applied Genetics and Cell Biology, BOKU, University of Natural Resources and Life Sciences, Muthgasse 18, A-1190 Vienna, Austria
Palabras clave:chlorophyll; cryptochrome; dactinomycin; phytochrome; plastoquinone; reactive oxygen metabolite; serine arginine rich protein; 2,5 dibromo 6 isopropyl 3 methylbenzoquinone; Arabidopsis protein; diuron; messenger RNA; plant RNA; adaptation; chloroplast; dicotyledon; gene expression; inhibition; light effect; photosynthesis; protein; alternative RNA splicing; Arabidopsis; Arabidopsis thaliana; article; chloroplast; chloroplast retrograde signal; circadian rhythm; controlled study; electron transport; gene expression; light; light dark cycle; light emitting diode; nonhuman; nonsense mediated mRNA decay; oxidation reduction state; phenotype; photosynthesis; plant gene; plant response; priority journal; respiratory chain; reverse transcription polymerase chain reaction; RNA processing; seedling; signal transduction; white light; biological model; cell nucleus; chloroplast; drug effects; gene expression regulation; genetics; metabolism; oxidation reduction reaction; plant leaf; plant root; RNA stability; signal transduction; transgenic plant; Arabidopsis; Alternative Splicing; Arabidopsis; Arabidopsis Proteins; Cell Nucleus; Chloroplasts; Circadian Clocks; Dibromothymoquinone; Diuron; Electron Transport; Gene Expression Regulation, Plant; Light; Models, Biological; Oxidation-Reduction; Photosynthesis; Plant Leaves; Plant Roots; Plants, Genetically Modified; Plastoquinone; RNA Stability; RNA, Messenger; RNA, Plant; Seedlings; Signal Transduction; Alternative Splicing; Arabidopsis; Arabidopsis Proteins; Cell Nucleus; Chloroplasts; Circadian Clocks; Dibromothymoquinone; Diuron; Electron Transport; Gene Expression Regulation, Plant; Light; Models, Biological; Oxidation-Reduction; Photosynthesis; Plant Leaves; Plant Roots; Plants, Genetically Modified; Plastoquinone; RNA Stability; RNA, Messenger; RNA, Plant; Seedling; Signal Transduction
Año:2014
Volumen:344
Número:6182
Página de inicio:427
Página de fin:430
DOI: http://dx.doi.org/10.1126/science.1250322
Título revista:Science
Título revista abreviado:Science
ISSN:00368075
CODEN:SCIEA
CAS:chlorophyll, 1406-65-1, 15611-43-5; cryptochrome, 73745-06-9; dactinomycin, 1402-38-6, 1402-58-0, 50-76-0; phytochrome, 117102-58-6; plastoquinone, 4299-57-4; 2,5 dibromo 6 isopropyl 3 methylbenzoquinone, 29096-93-3; diuron, 330-54-1; Arabidopsis Proteins; Dibromothymoquinone; Diuron; Plastoquinone; RNA, Messenger; RNA, Plant
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00368075_v344_n6182_p427_Petrillo

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Citas:

---------- APA ----------
Petrillo, E., Godoy Herz, M.A., Fuchs, A., Reifer, D., Fuller, J., Yanovsky, M.J., Simpson, C.,..., Kornblihtt, A.R. (2014) . A chloroplast retrograde signal regulates nuclear alternative splicing. Science, 344(6182), 427-430.
http://dx.doi.org/10.1126/science.1250322
---------- CHICAGO ----------
Petrillo, E., Godoy Herz, M.A., Fuchs, A., Reifer, D., Fuller, J., Yanovsky, M.J., et al. "A chloroplast retrograde signal regulates nuclear alternative splicing" . Science 344, no. 6182 (2014) : 427-430.
http://dx.doi.org/10.1126/science.1250322
---------- MLA ----------
Petrillo, E., Godoy Herz, M.A., Fuchs, A., Reifer, D., Fuller, J., Yanovsky, M.J., et al. "A chloroplast retrograde signal regulates nuclear alternative splicing" . Science, vol. 344, no. 6182, 2014, pp. 427-430.
http://dx.doi.org/10.1126/science.1250322
---------- VANCOUVER ----------
Petrillo, E., Godoy Herz, M.A., Fuchs, A., Reifer, D., Fuller, J., Yanovsky, M.J., et al. A chloroplast retrograde signal regulates nuclear alternative splicing. Science. 2014;344(6182):427-430.
http://dx.doi.org/10.1126/science.1250322