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El-Sayed, N.M.; Myler, P.J.; Bartholomeu, D.C.; Nilsson, D.; Aggarwal, G.; Tran, A.-N.; Ghedin, E.; Worthey, E.A.; Delcher, A.L.; Blandin, G.; Westenberger, S.J.; Caler, E.; Cerqueira, G.C.; Branche, C.; Haas, B.; Anupama, A.; Arner, E.; Åslund, L. (...) Andersson, B. "The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease" (2005) Science. 309(5733):409-415+435
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Abstract:

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.

Registro:

Documento: Artículo
Título:The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease
Autor:El-Sayed, N.M.; Myler, P.J.; Bartholomeu, D.C.; Nilsson, D.; Aggarwal, G.; Tran, A.-N.; Ghedin, E.; Worthey, E.A.; Delcher, A.L.; Blandin, G.; Westenberger, S.J.; Caler, E.; Cerqueira, G.C.; Branche, C.; Haas, B.; Anupama, A.; Arner, E.; Åslund, L.; Attipoe, P.; Bontempi, E.; Bringaud, F.; Burton, P.; Cadag, E.; Campbell, D.A.; Carrington, M.; Crabtree, J.; Darban, H.; Da Silveira, J.F.; De Jong, P.; Edwards, K.; Englund, P.T.; Fazelina, G.; Feldblyum, T.; Ferella, M.; Frasch, A.C.; Gull, K.; Horn, D.; Hou, L.; Huang, Y.; Kindlund, E.; Klingbeil, M.; Kluge, S.; Koo, H.; Lacerda, D.; Levin, M.J.; Lorenzi, H.; Louie, T.; Machado, C.R.; McCulloch, R.; McKenna, A.; Mizuno, Y.; Mottram, J.C.; Nelson, S.; Ochaya, S.; Osoegawa, K.; Pai, G.; Parsons, M.; Pentony, M.; Pettersson, U.; Pop, M.; Ramirez, J.L.; Rinta, J.; Robertson, L.; Salzberg, S.L.; Sanchez, D.O.; Seyler, A.; Sharma, R.; Shetty, J.; Simpson, A.J.; Sisk, E.; Tammi, M.T.; Tarleton, R.; Teixeira, S.; Van Aken, S.; Vogt, C.; Ward, P.N.; Wickstead, B.; Wortman, J.; White, O.; Fraser, C.M.; Stuart, K.D.; Andersson, B.
Filiación:Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, United States
Department of Microbiology and Tropical Medicine, George Washington University, Washington, DC 20052, United States
Seattle Biomedical Research Institute, Seattle, WA 98109, United States
Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, United States
Department of Medical Education and Biomedical Informatics, University of Washington, Seattle, WA 98195, United States
Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius väg 35, S-171 77 Stockholm, Sweden
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, United States
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, CEP 31270-901, Belo Horizonte, MG, Brazil
Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden
Instítuto Nacional de Parasitología Dr. M. Fatala Chabén, Administración Nacional de Laboratories e Insitutos de Salud (ANLIS), 1063, Buenos Aires, Argentina
Laboratoire de Génomique Fonctionnelle des Trypanosomatides, UMR-CNRS 5162, Université Victor Segalen Bordeaux II, 33076 Bordeaux Cedex, France
Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow G11 6NU, United Kingdom
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, CEP 04023-062, São Paulo, SP, Brazil
BACPAC Resources, Children's Hospital Oakland Research Institute, Oakland, CA 94609, United States
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States
Instituto de Investigaciones Biotecnologicas-Instituto Tecnologico de Chascomus, National University of San Martin, National Research Council, 1650 Buenos Aires, Argentina
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
Department of Microbiology, University of Massachusetts, Amherst, MA 01003, United States
René Rachou Research Center, CPqRR, Oswaldo Cruz Foundation, Belo Horizonte, MG, Brazil
Laboratory of Molecular Biology of Chagas Disease, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Centro de Genomica Aplicada-CeGA-University of Buenos Aires, 1428 Buenos Aires, Argentina
Instituto de Biología Experimental, Universidad Central de Venezuela and ADEA-MCT, 1041-A Caracas, Venezuela
Department of Biological Sciences, National University of Singapore, Singapore, Singapore
Center for Tropical and Emerging Global Diseases, Department of Cellular Biology, University of Georgia, Athens, GA 30602, United States
Palabras clave:Diseases; DNA; Genes; Proteins; Chagas diseases; Surface molecules; Trypanosoma cruzi; Protozoa; gene product; membrane protein; mitochondrial DNA; mucin; phosphatase; protein kinase; protozoal protein; sialidase; genome; allele; article; Chagas disease; diploidy; DNA repair; DNA replication; eukaryote; gene sequence; genome analysis; Leishmania major; molecular size; multigene family; nonhuman; priority journal; retroposon; signal transduction; Trypanosoma brucei; Trypanosoma cruzi; Animals; Chagas Disease; DNA Repair; DNA Replication; DNA, Mitochondrial; DNA, Protozoan; Genes, Protozoan; Genome, Protozoan; Humans; Meiosis; Membrane Proteins; Multigene Family; Protozoan Proteins; Recombination, Genetic; Repetitive Sequences, Nucleic Acid; Retroelements; Sequence Analysis, DNA; Signal Transduction; Telomere; Trypanocidal Agents; Trypanosoma cruzi; Eukaryota; Leishmania major; Protozoa; Trypanosoma cruzi
Año:2005
Volumen:309
Número:5733
Página de inicio:409
Página de fin:415+435
DOI: http://dx.doi.org/10.1126/science.1112631
Título revista:Science
Título revista abreviado:Science
ISSN:00368075
CODEN:SCIEA
CAS:phosphatase, 9013-05-2; protein kinase, 9026-43-1; sialidase, 9001-67-6; DNA, Mitochondrial; DNA, Protozoan; Membrane Proteins; Protozoan Proteins; Retroelements; Trypanocidal Agents
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00368075_v309_n5733_p409_ElSayed

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Citas:

---------- APA ----------
El-Sayed, N.M., Myler, P.J., Bartholomeu, D.C., Nilsson, D., Aggarwal, G., Tran, A.-N., Ghedin, E.,..., Andersson, B. (2005) . The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease. Science, 309(5733), 409-415+435.
http://dx.doi.org/10.1126/science.1112631
---------- CHICAGO ----------
El-Sayed, N.M., Myler, P.J., Bartholomeu, D.C., Nilsson, D., Aggarwal, G., Tran, A.-N., et al. "The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease" . Science 309, no. 5733 (2005) : 409-415+435.
http://dx.doi.org/10.1126/science.1112631
---------- MLA ----------
El-Sayed, N.M., Myler, P.J., Bartholomeu, D.C., Nilsson, D., Aggarwal, G., Tran, A.-N., et al. "The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease" . Science, vol. 309, no. 5733, 2005, pp. 409-415+435.
http://dx.doi.org/10.1126/science.1112631
---------- VANCOUVER ----------
El-Sayed, N.M., Myler, P.J., Bartholomeu, D.C., Nilsson, D., Aggarwal, G., Tran, A.-N., et al. The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease. Science. 2005;309(5733):409-415+435.
http://dx.doi.org/10.1126/science.1112631