The extrapolation of the "distributive-pairing hypothesis" of meiosis in Drosophila melanogaster females to human gametogenesis is proposed to account for the co-occurrence of rare karyotype abnormalities in human families. A description of the hypothesis is presented with its application to some established cases in the cytogenetic literature.
| Documento: | Artículo |
| Título: | Distributive pairing and aneuploidy in man |
| Autor: | Grell, R.F.; Valencia, J.I. |
| Filiación: | Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States Facultad de Ciencias, Universidad de Buenos Aires, Peru 222, Argentina |
| Palabras clave: | article; chromosome aberration; Down syndrome; Drosophila; EXPERIMENTAL LAB STUDY; GENETICS, HUMAN; medical genetics; research; CHROMOSOME ABNORMALITIES; DROSOPHILA; EXPERIMENTAL LAB STUDY; GENETICS, HUMAN; MONGOLISM; Chromosome Aberrations; Down Syndrome; Drosophila; Genetics, Medical; Research |
| Año: | 1964 |
| Volumen: | 145 |
| Número: | 3627 |
| Página de inicio: | 66 |
| Página de fin: | 67 |
| DOI: | http://dx.doi.org/10.1126/science.145.3627.66 |
| Título revista: | Science |
| ISSN: | 00368075 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00368075_v145_n3627_p66_Grell |
