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Abstract:

In order to examine inhibitory effects of hexachlorobenzene metabolites on the hepatic porphyrinogen carboxylyase activity, rat liver cytosol was incubated with uroporphyrinogen III and chlorinated phenols, thiophenols, thioanisoles and benzenes. Then, the occurrence of hepta-, hexa-, penta- and tetracarboxyporphyrinogen = coproporphyrinogen (measured as porphyrins) was determined. - Inhibitory effects were exerted by tetrachlorohydroquinone, pentachlorophenol, pentachlorothiophenol, 1,2,3,5- and 1,2,4,5- tetrachlorobenzene. Other compounds including hexachlorobenzene which was tested for comparative reasons did not impair uroporphyrinogen decarboxylation. - In the presence of tetrachlorohydroquinone, uroporphyrinogen merely was decarboxylated to hepta- and hexacarboxyporphyrinogen. Under the influence of the other 4 compounds with inhibitory effects, pentacarboxyporphyrinogen and coproporphyrinogen were formed additionally. - Coproporphyrinogen formation was inhibited completely by tetrachlorohydroquinone, while pentachlorophenol diminished its formation by about 50% and pentachlorothiophenol, 1,2,3,5- and 1,2,4,5-tetrachlorobenzene by less than 10%.

Registro:

Documento: Artículo
Título:Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase
Autor:Billi, S.C.; Koss, G.; San Martin de Viale, L.C.
Filiación:Laboratorio de Porfirias Experimentales y Metabolismo del Hemo, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Palabras clave:hexachlorobenzene; pentachlorophenol; tetrachlorohydroquinone; uroporphyrinogen decarboxylase; animal experiment; enzyme inhibition; liver; metabolite; nonhuman; pentachlorobenzenethiol; priority journal; tetrachlorobenzene; Animal; Carboxy-Lyases; Chlorobenzenes; Chlorophenols; Cytosol; Female; Hexachlorobenzene; Liver; Rats; Support, Non-U.S. Gov't; Uroporphyrinogens
Año:1986
Volumen:51
Número:3
Página de inicio:325
Página de fin:336
Título revista:Research Communications in Chemical Pathology and Pharmacology
Título revista abreviado:RES. COMMUN. CHEM. PATHOL. PHARMACOL.
ISSN:00345164
CODEN:RCOCB
CAS:hexachlorobenzene, 118-74-1, 55600-34-5; pentachlorophenol, 87-86-5; tetrachlorohydroquinone, 87-87-6; uroporphyrinogen decarboxylase, 9024-70-8; Carboxy-Lyases, EC 4.1.1.; Chlorobenzenes; Chlorophenols; Hexachlorobenzene, 118-74-1; pentachlorobenzene, 608-93-5; porphyrinogen carboxy-lyase, EC 4.1.1.-; Uroporphyrinogens
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00345164_v51_n3_p325_Billi

Citas:

---------- APA ----------
Billi, S.C., Koss, G. & San Martin de Viale, L.C. (1986) . Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase. Research Communications in Chemical Pathology and Pharmacology, 51(3), 325-336.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00345164_v51_n3_p325_Billi [ ]
---------- CHICAGO ----------
Billi, S.C., Koss, G., San Martin de Viale, L.C. "Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase" . Research Communications in Chemical Pathology and Pharmacology 51, no. 3 (1986) : 325-336.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00345164_v51_n3_p325_Billi [ ]
---------- MLA ----------
Billi, S.C., Koss, G., San Martin de Viale, L.C. "Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase" . Research Communications in Chemical Pathology and Pharmacology, vol. 51, no. 3, 1986, pp. 325-336.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00345164_v51_n3_p325_Billi [ ]
---------- VANCOUVER ----------
Billi, S.C., Koss, G., San Martin de Viale, L.C. Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase. RES. COMMUN. CHEM. PATHOL. PHARMACOL. 1986;51(3):325-336.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00345164_v51_n3_p325_Billi [ ]