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Cifre, I.; Sitges, C.; Fraiman, D.; Muñoz, M.A.; Balenzuela, P.; González-Roldán, A.; Martínez-Jauand, M.; Birbaumer, N.; Chialvo, D.R.; Montoya, P. "Disrupted functional connectivity of the pain network in fibromyalgia" (2012) Psychosomatic Medicine. 74(1):55-62
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Abstract:

Objective: To investigate the impact of chronic pain on brain dynamics at rest. Methods: Functional connectivity was examined in patients with fibromyalgia (FM) (n = 9) and healthy controls (n = 11) by calculating partial correlations between low-frequency blood oxygen level-dependent fluctuations extracted from 15 brain regions. Results: Patients with FM had more positive and negative correlations within the pain network than healthy controls. Patients with FM displayed enhanced functional connectivity of the anterior cingulate cortex (ACC) with the insula (INS) and basal ganglia (p values between .01 and .05), the secondary somatosensory area with the caudate (CAU) (p = .012), the primary motor cortex with the supplementary motor area (p = .007), the globus pallidus with the amygdala and superior temporal sulcus (both p values < .05), and the medial prefrontal cortex with the posterior cingulate cortex (PCC) and CAU (both p values < .05). Functional connectivity of the ACC with the amygdala and periaqueductal gray (PAG) matter (p values between .001 and .05), the thalamus with the INS and PAG (both p values < .01), the INS with the putamen (p = .038), the PAG with the CAU (p = .038), the secondary somatosensory area with the motor cortex and PCC (both p values < .05), and the PCC with the superior temporal sulcus (p = .002) was also reduced in FM. In addition, significant negative correlations were observed between depression and PAG connectivity strength with the thalamus (r =-0.64, p = .003) and ACC (r =-0.60, p = .004). Conclusions: These findings demonstrate that patients with FM display a substantial imbalance of the connectivity within the pain network during rest, suggesting that chronic pain may also lead to changes in brain activity during internally generated thought processes such as occur at rest. © 2012 by the American Psychosomatic Society.

Registro:

Documento: Artículo
Título:Disrupted functional connectivity of the pain network in fibromyalgia
Autor:Cifre, I.; Sitges, C.; Fraiman, D.; Muñoz, M.A.; Balenzuela, P.; González-Roldán, A.; Martínez-Jauand, M.; Birbaumer, N.; Chialvo, D.R.; Montoya, P.
Filiación:Research Institute on Health Sciences, University of Balearic Islands, Cra. Valldemossa km 7.5, 07122 Palma de Mallorca, Spain
Consejo Nacional de Investigaciones Científicas y Tecnológicas, Argentina
Departamento de Ciencias, Universidad de San Andres, Argentina
Departamento de Física, Universidad de Buenos Aires, Buenos Aires, Argentina
Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany
Ospedale San Camillo, Instituto di Ricovero e Cura A Carattere Scientifico, Venezia, Italy
Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, United States
Palabras clave:chronic pain; fibromyalgia; functional connectivity; partial correlation analysis; resting state; analgesic agent; antidepressant agent; anxiolytic agent; central muscle relaxant; nonsteroid antiinflammatory agent; adult; aged; amygdaloid nucleus; article; basal ganglion; brain function; brain region; caudate nucleus; chronic pain; cingulate gyrus; clinical article; controlled study; depression; female; fibromyalgia; functional connectivity; globus pallidus; gray matter; human; insula; male; nerve cell network; oxygen blood level; pain assessment; periaqueductal gray matter; posterior cingulate; primary motor cortex; priority journal; rest; somatosensory cortex; superior temporal sulcus; supplementary motor area; thalamus; ventromedial prefrontal cortex
Año:2012
Volumen:74
Número:1
Página de inicio:55
Página de fin:62
DOI: http://dx.doi.org/10.1097/PSY.0b013e3182408f04
Título revista:Psychosomatic Medicine
Título revista abreviado:Psychosom. Med.
ISSN:00333174
CODEN:PSMEA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00333174_v74_n1_p55_Cifre

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Citas:

---------- APA ----------
Cifre, I., Sitges, C., Fraiman, D., Muñoz, M.A., Balenzuela, P., González-Roldán, A., Martínez-Jauand, M.,..., Montoya, P. (2012) . Disrupted functional connectivity of the pain network in fibromyalgia. Psychosomatic Medicine, 74(1), 55-62.
http://dx.doi.org/10.1097/PSY.0b013e3182408f04
---------- CHICAGO ----------
Cifre, I., Sitges, C., Fraiman, D., Muñoz, M.A., Balenzuela, P., González-Roldán, A., et al. "Disrupted functional connectivity of the pain network in fibromyalgia" . Psychosomatic Medicine 74, no. 1 (2012) : 55-62.
http://dx.doi.org/10.1097/PSY.0b013e3182408f04
---------- MLA ----------
Cifre, I., Sitges, C., Fraiman, D., Muñoz, M.A., Balenzuela, P., González-Roldán, A., et al. "Disrupted functional connectivity of the pain network in fibromyalgia" . Psychosomatic Medicine, vol. 74, no. 1, 2012, pp. 55-62.
http://dx.doi.org/10.1097/PSY.0b013e3182408f04
---------- VANCOUVER ----------
Cifre, I., Sitges, C., Fraiman, D., Muñoz, M.A., Balenzuela, P., González-Roldán, A., et al. Disrupted functional connectivity of the pain network in fibromyalgia. Psychosom. Med. 2012;74(1):55-62.
http://dx.doi.org/10.1097/PSY.0b013e3182408f04