Artículo
Maffei, M.E.; Kujareuk, M.; Barrionuevo, A.; Galatro, G.; Caviglia, H. "Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental" (1997) Prensa Medica Argentina. 84(7):716-721
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Abstract:
Chronic synovitis is an unsolved problem in hemophilic patients still today. Synoviorthesis proves effective among the possible treatments. The use of radioactive agents such as 198 Au-colloidal gold and 90 Y-colloidal Yttrium presents limitations due to age and joint size, Instead, Rifamicine my be used in children with open cartilages and in small joints. Its action mechanism has not been tried with hemophilic patients up to the present moment. The objective of the present paper is to demonstrate how Rifamicine works on rabbit knees with synovitis caused through intra-articular blood injection. We used 18 New Zeeland white rabbits (approximately 6 months old and 1.5 - 2.5 kg weight). An intra-articular injection of 1 ml homologous blood in the right knee was used twice a day for 8 weeks with the purpose of producing a synovitis. The left knees served as controls and received injections at the same time of normal saline solution. Two rabbits were killed to observe intraarticular alterations. The remaining rabbits received 1 ml (5 mg) intra-articular Rifamicine each 7 days for 2 weeks. Four were killed at 10 weeks; 4 at 11; 4 at 12 and 4 at 16 weeks. The joints were studied histologically and the reactional phenomenae that had been produced by Rifamicine on the vascular hyperplasia of the synovitis secondary to hemarthrosis were observed.
Registro:
| Documento: | Artículo |
| Título: | Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental |
| Autor: | Maffei, M.E.; Kujareuk, M.; Barrionuevo, A.; Galatro, G.; Caviglia, H. |
| Filiación: | Div. Patol. Htal. Fernández, Encargada Docente UDH Htal. F., (1870) Pcia. de Buenos Aires, Argentina Cátedra de Histol. y Embriol., USAL, Fac. Medicina, (1870) Pcia. de Buenos Aires, Argentina Citol. Histol. Curso Sup. Medicos E., USAL, Chacabuco 24 7o A, (1870) Pcia. de Buenos Aires, Argentina Catedra Histol. Embriol. de la USAL, Ayudante de 1o UDH, Htal. Fernandez, Av. Díaz Velez 4565 7o C, (1405) Buenos Aires, Argentina Medica de Guardia Htal. Fernandez, Miembro Equipo Cadera Htal. F., (1428) Buenos Aires, Argentina Trabajos Practicos Traumatologia C., Arcos 1745 2 A, (1428) Buenos Aires, Argentina Medico de Guardia Htal. Fernandez, Miembro Equipo Cadera Htal. F., Fundación de la Hemofilia, Gascón 1682 4o A, (1425) Buenos Aires, Argentina Unidad del Htal. Fernández, (1875) Wilde. Pcia. de Buenos Aires, Argentina Equipo de Cadera del Htal. Fernandez, (1875) Wilde. Pcia. de Buenos Aires, Argentina Extraordinario Carrera Ortopedia T., USAL, (1875) Wilde. Pcia. de Buenos Aires, Argentina Carrera de Medicina, Fundación Favaloro, (1875) Wilde. Pcia. de Buenos Aires, Argentina Ortopedia y Traumatología, Fundación de la Hemofilia, Sadi Carnot 131, (1875) Wilde. Pcia. de Buenos Aires, Argentina |
| Palabras clave: | gold 198; rifamycin; yttrium; article; hemarthrosis; hemophilia; hyperplasia; injection; synovitis; treatment outcome |
| Año: | 1997 |
| Volumen: | 84 |
| Número: | 7 |
| Página de inicio: | 716 |
| Página de fin: | 721 |
| Título revista: | Prensa Medica Argentina |
| Título revista abreviado: | Prensa Med. Argent. |
| ISSN: | 0032745X |
| CODEN: | PMARA |
| CAS: | gold 198, 10043-49-9; rifamycin, 6998-60-3; yttrium, 7440-65-5 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0032745X_v84_n7_p716_Maffei |
Referencias:
- Arnold, W.D., Hilgartner, M.W., Hemophilic arthropaty. Current concepts of pathogenesis and management (1977) J.Bone & Joint Surg., 59 A, pp. 287-305
- Handelsman, J.E., The knee joint in hemophilia (1979) Clin. Orthop., 10, pp. 139-173
- Ahlberg, A., Treatment and prophylaxis of arthropathy in severe hemophilia (1967) Clin. Orthop., 53, pp. 135-146
- Handelsman, J.E., Levine, A.L., Rippey, J.J., Hill, R.R., Sweet, M.B., Thonar, E.J., The natural history of haemophilic arthritis (1977) Thromb & Haemostas, 38 (1), p. 351
- France, W.G., Wolf, P., Treatment and prevention of chronic haemorrhagic arthropaty and contractures in hemophilia (1965) J.Bone &Joint Suregry, 47 B, p. 247
- Ahlberg, A., Hemophilia in Sweden : VII Incidence, treatment and prophylaxis of arthropathy and other musculo-skeletal manifestations of hemophilia A and B (1965) Acta Orthopaed Scand, 77 (5 SUPPL.)
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- Bennetts, C., Myers, M., Ewald, B.A., Elective synovectomy in hemophilia (1977) Thromb & Haemostas, p. 38
- Canale, S.T., Dugdale, M., Howard, B.C., Synovectorny of the knee in young patients with hemophilia (1988) Southern Med J, 81, pp. 1480-1486
- Clark, M.W., Knee synovectomy in hemophilia (1978) Orthop, 1, pp. 285-290
- Greene, W.B., Mcmillan, C.W., Dykstra, W., Warren, M., Treatment of hypertrophic synovitis and recurrent hemarthrosis in children with severe hemophilia (1983) Develop Med, 25, p. 112
- Pietrogrande, V., Mannucci, P.M., Torri, G., Rugerri, Z.M., Synovectomy revisited (1977) Thromb & Haemostas, 38, p. 352
- Storti, E., Ascari, E., Gamba, G., Post-operative complications and joint function after knee synovectomy in hemophiliacs (1982) Br J Haematol, 50, pp. 544-546
- Storti, E., Ascari, E., Turpini, R., Molinarl, E., Gamba, G., Pattene, A., Epsilon-amino-caproic acid for synovectomy in haemophilic patients (1972) Acta Haematol, 47, p. 146
- Ahlberg, A., Mikulowski, P., Odelberg-Johnson, O., Intra-articular injection of radioactive gold in treatment of chronic synovial effusion in the knee (1969) Acta Rheum Scand, 1, p. 581
- Ahlberg, A., Radioactive gold in the treatment of chronic synovial effusion in haemophilia (1973) Haemophilia, pp. 212-215. , Ala, F Denson K, eds. Amsterdam: Excerpta Medica
- Dato no publicado; Wiedel, J.D., Arthroscopic synovectomy in hemophilic arthropathy of the knee (1984) Scand J Haematol, 33 (40 SUPPL.), pp. 263-270
- Wiedel, J.D., Arthroscopic synovectomy for chronic hemophilic synovitis of the knee (1985) Arthrosc, 1, pp. 205-209
- Limbird, T.J., Dennis, S.C., The treatment of hemophilic arthrophaty by arthroscopic synovectomy (1986) Orthop. Trans., 10, p. 617
- Toft, L.A., Arthroscopic synovectomy for recurrent haemarthrosis in the knee (1990) Musculoskeletal Problems in Hemophilia, pp. 112-114. , Gilbert MS, Greene WB, eds. New York: National Hemophilia Foundation
Citas:
---------- APA ----------
Maffei, M.E., Kujareuk, M., Barrionuevo, A., Galatro, G. & Caviglia, H. (1997) . Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental. Prensa Medica Argentina, 84(7), 716-721.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0032745X_v84_n7_p716_Maffei [ ]
---------- CHICAGO ----------
Maffei, M.E., Kujareuk, M., Barrionuevo, A., Galatro, G., Caviglia, H. "Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental" . Prensa Medica Argentina 84, no. 7 (1997) : 716-721.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0032745X_v84_n7_p716_Maffei [ ]
---------- MLA ----------
Maffei, M.E., Kujareuk, M., Barrionuevo, A., Galatro, G., Caviglia, H. "Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental" . Prensa Medica Argentina, vol. 84, no. 7, 1997, pp. 716-721.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0032745X_v84_n7_p716_Maffei [ ]
---------- VANCOUVER ----------
Maffei, M.E., Kujareuk, M., Barrionuevo, A., Galatro, G., Caviglia, H. Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental. Prensa Med. Argent. 1997;84(7):716-721.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0032745X_v84_n7_p716_Maffei [ ]
