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Abstract:

A linear polyamidoamine oligomer was obtained by polymerization of ethyl acrylate and N-methyl-1,3-diaminopropane, catalyzed by the Candida antarctica lipase. Depending on the reaction conditions such as substrates concentration, solvent and enzyme:substrate ratio, the enzyme catalyzes the polymerization reaction or Michael adducts formation. The polymeric material, characterized by FTIR, 1H and 13C NMR and UV-MALDI-TOF-MS, shows low molecular weight and high monodispersity. The activity showed by C. antarctica lipase in the polymerization reaction is highly selective and allows to obtain a product with potential biomedical applications in mild condition reactions and low environmental impact. © 2010 Elsevier Ltd.

Registro:

Documento: Artículo
Título:Lipase-catalyzed synthesis and characterization of a novel linear polyamidoamine oligomer
Autor:Monsalve, L.N.; Kaniz Fatema, M.; Nonami, H.; Erra-Balsells, R.; Baldessari, A.
Filiación:Laboratorio de Biocatálisis, Departamento de Química Orgánica y UMYMFOR, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina
Plant Biophysics/Biochemistry Research Laboratory, College of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama 790-8566, Japan
CIHIDECAR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina
Palabras clave:Lipase-catalyzed; Michael addition; Polyamidoamine oligomer; Addition reactions; Environmental impact; Enzymes; Functional polymers; Medical applications; Oligomers; Polymerization; Substrates; Biomedical applications; Candida antarctica lipase; Lipase-catalyzed; Lipase-catalyzed synthesis; Michael additions; Polyamidoamine oligomers; Polymerization reaction; Substrates concentration; Catalysis; biomedical use; catalyst; chemical reaction; environmental impact; oligomer; polymerization; substrate
Año:2010
Volumen:51
Número:14
Página de inicio:2998
Página de fin:3005
DOI: http://dx.doi.org/10.1016/j.polymer.2010.04.071
Título revista:Polymer
Título revista abreviado:Polymer
ISSN:00323861
CODEN:POLMA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00323861_v51_n14_p2998_Monsalve

Referencias:

  • Kurtoglu, Y.E., Mishra, M.K., Kannan, S., Kannan, R.M., (2010) Int J Pharm, 384, pp. 189-194
  • Ranucci, E., Spagnoli, P., Ferruti, P., Sgouras, D., Duncan, R., (1991) J Biomater Sci Polymer Ed, 2, pp. 303-315
  • Ferruti, P., Ranucci, E., Sartore, L., Bignotti, F., Marchisio, M.A., Bianciardi, P., (1994) Biomaterials, 15, pp. 1235-1241
  • Ferruti, P., Manzoni, S., Richardson, S.C.W., Duncan, R., Pattrick, N.G., Mendichi, R., (2000) Macromolecules, 33, pp. 7793-7800
  • Svenson, S., (2009) Eur J Pharm Biopharm, 71, pp. 445-462
  • Lai, P.S., Lou, P.J., Peng, C., Pai, C., Yen, W.N., Huang, M.Y., (2007) J Control Release, 122, pp. 39-46
  • Ferruti, P., Ranucci, E., Trotta, F., Gianasi, E., Evagorou, E.G., Wasil, M., (1999) Macromol Chem Phys, 200, pp. 1644-1654
  • Yang, W., Cheng, Y., Xu, T., Wang, X., Wen, L.P., (2009) Eur J Med Chem, 44, pp. 862-868
  • Bai, S., Thomas, C., Ahsan, F., (2007) J Pharm Sci, 96, pp. 2090-2106
  • Mok, H., Park, T.G., (2009) Macromol Biosci, 9, pp. 731-743
  • Milhem, O.M., Myles, C., McKeown, N.B., Attwood, D., D'Emanuele, A., (2000) Int J Pharm, 197, pp. 239-241
  • Yiyun, C., Tongwen, X., (2005) Eur J Med Chem, 40, pp. 1188-1192
  • Pattrick, N.G., Richardson, S.C.W., Casolaro, M., Ferruti, P., Duncan, R., (2001) J Control Release, 77, pp. 225-232
  • Joshi, N., Grinstaff, M., (2008) Curr Top Med Chem, 8, pp. 1225-1236
  • Börner, H.G., (2009) Prog Polym Sci, 34, pp. 811-851
  • Gussoni, M., Greco, F., Ferruti, P., Ranucci, E., Ponti, A., Zetta, L., (2008) New J Chem, 32, pp. 323-332
  • Emilitri, E., Ferruti, P., Annunaziata, R., Ranucci, E., Rossi, M., Falciola, L., (2007) Macromolecules, 40, pp. 4785-4793
  • Ranucci, E., Ferruti, P., Suardi, M.A., Manfredi, A., (2007) Macromol Rapid Commun, 28, pp. 1243-1250
  • Franchini, J., Ranucci, E., Ferruti, P., Rossi, M., Cavalli, R., (2006) Biomacromolecules, 7, pp. 1215-1222
  • Lavignac, N., Lazenby, M., Franchini, J., Ferruti, P., Duncan, R., (2005) Int J Pharm, 300, pp. 102-112
  • Malgesini, F., Ferruti, P., Manfredi, A., Casolaro, M., Chiellini, F., (2005) J Bioact Compat Polym, 20, pp. 377-394
  • Emilitri, E., Ranucci, E., Ferrruti, P., (2005) J Polym Sci Part A Polym Chem, 43, pp. 1404-1416
  • Franchini, J., Ferruti, P., (2004) J Bioact Compat Polym, 19, pp. 221-236
  • Tanzi, M.C., Rusconi, L., Barozzi, C., Ferruti, P., Angiolini, L., Nocentini, M., (1984) Polymer, pp. 863-868
  • Harmann, L., Krause, E., Antonietti, M., Börner, H.G., (2006) Biomacromolecules, 7, pp. 1239-1244
  • Bommarius, A.S., Riebel, B.R., (2004) Biocatalysis, fundamentals and applications, , Wiley-VCH, Weinheim, [chapter 1]
  • Gotor, V., Alfonso, I., García Urdiales, E., (2008) Asymmetric organic synthesis with enzymes, , Wiley-VCH, Weinheim
  • Kobayashi, S., Ritter, H., Kaplan, D., (2006) Enzyme-catalyzed synthesis of polymers, advances in polymer science series, 194. , Springer-Verlag, Berlin Heidelberg
  • Gross, R.A., Cheng, H.N., Biocatalysis in polymer science (2002) ACS symposium series, 840. , ACS, Washington
  • Kim, Y.J., Shibata, K., Uyama, H., Kobayashi, S., (2008) Polymer, 49, pp. 4791-4795
  • Zini, E., Scandola, M., Jiang, Z., Liu, C., Gross, R.A., (2008) Macromolecules, 41, pp. 4681-4687
  • Chen, B., Hu, J., Milller, E.M., Xie, W., Cai, M., Gross, R.A., (2008) Biomacromolecules, 9, pp. 463-471
  • Iglesias, L.E., Fukuyama, Y., Nonami, H., Erra-Balsells, R., Baldessari, A., (1999) Biotechnol Tech, 13, pp. 923-926
  • Rustoy, E.M., Sato, Y., Nonami, H., Erra-Balsells, R., Baldessari, A., (2007) Polymer, 48, pp. 1517-1525
  • http://fscimage.fishersci.com/msds/26848.htm, MSDS, ACC#26848; Nonami, H., Fukui, S., Erra-Balsells, R., (1997) J Mass Spectrom, 32, pp. 287-296
  • Nonami, H., Tanaka, K., Fukuyama, Y., Erra-Balsells, R., (1998) Rapid Commun Mass Spectrom, 12, pp. 285-296
  • Erra-Balsells, R., Nonami, H., (2002) Environ Control Biol, 40, pp. 55-73
  • Torre, O., Gotor Fernandez, V., Alfonso, I., García-Alles, L.F., Gotor, V., (2005) Adv Synth Catal, 347, pp. 1007-1014
  • Rustoy, E.M., Baldessari, A., (2006) J Mol Catal B Enzym, 39, pp. 50-54
  • Baldessari, A., Mangone, C.P., (2001) J Mol Catal B Enzym, 11, pp. 335-341
  • Ferruti, P., Marchisio, M.A., Duncan, R., (2002) Macromol Rapid Commun, 23, pp. 332-355

Citas:

---------- APA ----------
Monsalve, L.N., Kaniz Fatema, M., Nonami, H., Erra-Balsells, R. & Baldessari, A. (2010) . Lipase-catalyzed synthesis and characterization of a novel linear polyamidoamine oligomer. Polymer, 51(14), 2998-3005.
http://dx.doi.org/10.1016/j.polymer.2010.04.071
---------- CHICAGO ----------
Monsalve, L.N., Kaniz Fatema, M., Nonami, H., Erra-Balsells, R., Baldessari, A. "Lipase-catalyzed synthesis and characterization of a novel linear polyamidoamine oligomer" . Polymer 51, no. 14 (2010) : 2998-3005.
http://dx.doi.org/10.1016/j.polymer.2010.04.071
---------- MLA ----------
Monsalve, L.N., Kaniz Fatema, M., Nonami, H., Erra-Balsells, R., Baldessari, A. "Lipase-catalyzed synthesis and characterization of a novel linear polyamidoamine oligomer" . Polymer, vol. 51, no. 14, 2010, pp. 2998-3005.
http://dx.doi.org/10.1016/j.polymer.2010.04.071
---------- VANCOUVER ----------
Monsalve, L.N., Kaniz Fatema, M., Nonami, H., Erra-Balsells, R., Baldessari, A. Lipase-catalyzed synthesis and characterization of a novel linear polyamidoamine oligomer. Polymer. 2010;51(14):2998-3005.
http://dx.doi.org/10.1016/j.polymer.2010.04.071