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Lang, K.L.; Da Rosa Guimarães, T.; Rocha MacHado, V.; Zimmermann, L.A.; Silva, I.T.; Teixeira, M.R.; Durán, F.J.; Palermo, J.A.; Simões, C.M.O.; Caro, M.S.B.; Schenkel, E.P. "New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn" (2011) Planta Medica. 77(14):1648-1651
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Abstract:

Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (12) and four known (36) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity. © Georg Thieme Verlag KG Stuttgart·New York·.

Registro:

Documento: Artículo
Título:New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn
Autor:Lang, K.L.; Da Rosa Guimarães, T.; Rocha MacHado, V.; Zimmermann, L.A.; Silva, I.T.; Teixeira, M.R.; Durán, F.J.; Palermo, J.A.; Simões, C.M.O.; Caro, M.S.B.; Schenkel, E.P.
Filiación:Department of Chemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil
Department of Pharmaceutical Science Federal, University of Santa Catarina (UFSC), Campus Universitário Trindade Florianópolis, R. Delfino Conti, s/n, CEP 88040-900 Santa Catarina, Brazil
UMYMFOR Department of Organic Chemistry, University of Buenos Aires, Buenos Aires, Argentina
Palabras clave:Cucurbitaceae; cucurbitacins; cytotoxicity; Wilbrandia ebracteata; 2beta,16alpha, tetrahydroxy 10alpha,17alpha cucurbit 5,24 dien 3,11 dione; 2beta,16alpha, trihydroxy 10alpha,17alpha cucurbit 5,25 dien 3,11,22 trione; cucurbitacin; cytotoxic agent; unclassified drug; Wilbrandia ebracteata extract; article; chemical structure; cucumber; cytotoxicity; drug isolation; human; human cell; in vitro study; mass spectrometry; nuclear magnetic resonance; plant root; Wilbrandia ebracteata; Brazil; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Cucurbitaceae; Cucurbitacins; Humans; Medicine, Traditional; Molecular Structure; Plant Extracts; Plant Roots; Plants, Medicinal; Spectrometry, Mass, Electrospray Ionization; Cucurbitaceae; Wilbrandia ebracteata
Año:2011
Volumen:77
Número:14
Página de inicio:1648
Página de fin:1651
DOI: http://dx.doi.org/10.1055/s-0030-1270962
Título revista:Planta Medica
Título revista abreviado:Planta Med.
ISSN:00320943
CODEN:PLMEA
CAS:Cucurbitacins, 60137-06-6; Plant Extracts
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v77_n14_p1648_Lang

Referencias:

  • Pio Corrêa, M., (1984) Dicionário das Plantas Úteis Do Brasil e das Exóticas Cultivadas, p. 458. , Rio de Janeiro Imprensa Nacional
  • Moreira, N.J., (1862) Dicionário de Plantas Medicinais Brasileiras, p. 122. , Rio de Janeiro Correio Mercantil
  • Rizzini, C.T., Mors, W.B., (1976) Botânica Econômica Brasileira, p. 207. , São Paulo EDUSP
  • D'Ávila, M.C., (1910) Da Flora Medicinal Do Rio Grande Do sul [Dissertation], , Porto Alegre Universidade Federal do Rio Grande do Sul
  • (1929) Farmacopéia Brasileira, 1st Edition, p. 885. , São Paulo Atheneu
  • Santos, R.I., Santos, M.A., Schenkel, E.P., Analysis of the plant drug Wilbrandia ebracteata (Cogn.) (1996) Int J Pharmacognosy, 34, pp. 300-302
  • Gonzalez, F.G., Di Stasi, L.C., Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice (2002) Phytomedicine, 9 (2), pp. 125-134
  • Schenkel, E.P., Farias, M.R., Mayer, R., Breitmaier, E., Rucker, G., Cucurbitacins from Wilbrandia ebracteata (1992) Phytochemistry, 31, pp. 1329-1333
  • Farias, M.R., Schenkel, E.P., Mayer, R., Rucker, G., Cucurbitacins as constituents of Wilbrandia ebracteata (1993) Planta Medica, 59 (3), pp. 272-275
  • Siqueira Jr., J.M., Peters, R.R., Gazola, A.C., Krepsky, P.B., Farias, M.R., Rae, G.A., De Brum-Fernandes, A.J., Ribeiro-do-Valle, R.M., Anti-inflammatory effects of a triterpenoid isolated from Wilbrandia ebracteata Cogn. (2007) Life Sciences, 80 (15), pp. 1382-1387. , DOI 10.1016/j.lfs.2006.12.021, PII S0024320507000215
  • Siqueira, J.M., Gazola, A.C., Farias, M.R., Volkov, L., Rivard, N., Brum-Fernandes, A.J., Ribeiro-Do-Valle, R.M., Evaluation of the antitumoral effect of dihydrocucurbitacin-B in both in vitro and in vivo models (2009) Cancer Chemother Pharmacol, 64, pp. 529-538
  • Krepsky, P.B., Cervelin, M.O., Porath, D., Peters, R.R., Ribeiro-Do-Valle, R.M., Farias, M.R., High performance liquid chromatography determination of cucurbitacins in the roots of Wilbrandia ebracteata Cogn (2009) Braz J Pharmacognosy, 19, pp. 715-719
  • Stuppner, H., Kahlig, H., Seligmann, O., Wagner, H., Minor cucurbitacin glycosides from Picrorhiza kurrooa (1990) Phytochemistry, 29, pp. 1633-1637
  • Hylands, P.J., Magd, M.S., Cucurbitacins from Acanthosicyos horridus (1986) Phytochemistry, 25, pp. 1681-1684
  • Mosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays (1983) Journal of Immunological Methods, 65 (1-2), pp. 55-63
  • Van Dang, G., Rode, B.M., Stuppner, H., Quantitative electronic structure-activity relationship (QESAR) of natural cytotoxic compounds: Maytansinoids, quassinoids and cucurbitacins (1994) Eur J Pharm Sci, 2, pp. 331-350
  • Ríos, J.L., Escandell, J.M., Recio, M.C., New insights into the bioactivity of cucurbitacins (2005) Stud Nat Prod Chem, 32, pp. 429-469

Citas:

---------- APA ----------
Lang, K.L., Da Rosa Guimarães, T., Rocha MacHado, V., Zimmermann, L.A., Silva, I.T., Teixeira, M.R., Durán, F.J.,..., Schenkel, E.P. (2011) . New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn. Planta Medica, 77(14), 1648-1651.
http://dx.doi.org/10.1055/s-0030-1270962
---------- CHICAGO ----------
Lang, K.L., Da Rosa Guimarães, T., Rocha MacHado, V., Zimmermann, L.A., Silva, I.T., Teixeira, M.R., et al. "New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn" . Planta Medica 77, no. 14 (2011) : 1648-1651.
http://dx.doi.org/10.1055/s-0030-1270962
---------- MLA ----------
Lang, K.L., Da Rosa Guimarães, T., Rocha MacHado, V., Zimmermann, L.A., Silva, I.T., Teixeira, M.R., et al. "New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn" . Planta Medica, vol. 77, no. 14, 2011, pp. 1648-1651.
http://dx.doi.org/10.1055/s-0030-1270962
---------- VANCOUVER ----------
Lang, K.L., Da Rosa Guimarães, T., Rocha MacHado, V., Zimmermann, L.A., Silva, I.T., Teixeira, M.R., et al. New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn. Planta Med. 2011;77(14):1648-1651.
http://dx.doi.org/10.1055/s-0030-1270962