Artículo

Del Pacciaroni, A.V.; Mongelli, E.; Espinar, L.A.; Romano, A.; Ciccia, G.; Silva, G.L. "Bioactive constituents of Conyza albida" (2000) Planta Medica. 66(8):720-723
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Abstract:

The bioactivity-guided fractionation of an active chloroform extract of Conyza albida led to the isolation of three alkenynes, deca-4,6-diyn-2-(Z)-enoic methyl ester (1), deca-4,6-diyn-2-(Z)-enoic ethyl ester (2) and deca-2,4-diene-4-hydroxy-6-yn-l,4-olide (3), and the terpenoid spathulenol (4), as the active toxic metabolites in the Artemia sp. lethality test. When tested in the KB cell cytotoxicity assay, compounds 1-4 demonstrated 1C 50 values of 52.2, 38.4, 117.9, and 83.8 μM, respectively. All compounds studied were inactive in the DNA methyl green and DNA strand scission assays, while compounds 3 and 4 showed moderate activity as inhibitors of human topoisomerase I. Compound 2 is reported here for the first time.

Registro:

Documento: Artículo
Título:Bioactive constituents of Conyza albida
Autor:Del Pacciaroni, A.V.; Mongelli, E.; Espinar, L.A.; Romano, A.; Ciccia, G.; Silva, G.L.
Filiación:Departamento de Química Orgánica, Facultad de Ciencias Quím. U.N.C., IMBIV-CONICET, Pabellón de Ciencias II, Ciudad Universitaria, 5000 Córdoba, Argentina
Cátedra de Microbiología Industrial y Biotecnología, IQUIMEFA-CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina
Cátedra de Farmacognosia, IQUIMEFA-CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina
Idioma: Inglés
Palabras clave:Alkenynes; Compositae; Conyza albida; Cytotoxic activity; DNA interaction; DNA strand scission; Topoisomerase 1; chloroform; deca 2,4 diene 4 hydroxy 6 yn 1,4 olide; deca 4,6 diyn 2 enoic ethyl ester; deca 4,6 diyn 2 enoic methyl ester; DNA; DNA topoisomerase; methyl green; plant extract; spathulenol; unclassified drug; animal experiment; article; controlled study; cytotoxicity; drug activity; fractionation; human; human cell; medicinal plant; nonhuman; plant leaf; shrimp; Asteraceae; Humans; Molecular Structure; Plant Extracts; Spectrum Analysis
Año:2000
Volumen:66
Número:8
Página de inicio:720
Página de fin:723
DOI: http://dx.doi.org/10.1055/s-2000-9600
Título revista:Planta Medica
Título revista abreviado:Planta Med.
ISSN:00320943
CODEN:PLMEA
CAS:DNA, 9007-49-2; DNA topoisomerase, 80449-01-0; chloroform, 67-66-3; methyl green, 54327-10-5; spathulenol, 6750-60-3; Plant Extracts
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v66_n8_p720_DelPacciaroni

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Citas:

---------- APA ----------
Del Pacciaroni, A.V., Mongelli, E., Espinar, L.A., Romano, A., Ciccia, G. & Silva, G.L. (2000) . Bioactive constituents of Conyza albida. Planta Medica, 66(8), 720-723.
http://dx.doi.org/10.1055/s-2000-9600
---------- CHICAGO ----------
Del Pacciaroni, A.V., Mongelli, E., Espinar, L.A., Romano, A., Ciccia, G., Silva, G.L. "Bioactive constituents of Conyza albida" . Planta Medica 66, no. 8 (2000) : 720-723.
http://dx.doi.org/10.1055/s-2000-9600
---------- MLA ----------
Del Pacciaroni, A.V., Mongelli, E., Espinar, L.A., Romano, A., Ciccia, G., Silva, G.L. "Bioactive constituents of Conyza albida" . Planta Medica, vol. 66, no. 8, 2000, pp. 720-723.
http://dx.doi.org/10.1055/s-2000-9600
---------- VANCOUVER ----------
Del Pacciaroni, A.V., Mongelli, E., Espinar, L.A., Romano, A., Ciccia, G., Silva, G.L. Bioactive constituents of Conyza albida. Planta Med. 2000;66(8):720-723.
http://dx.doi.org/10.1055/s-2000-9600