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Abstract:

A sulphated galactan (SG) with low molecular weight (app. 2800) was isolated from extracts of Cryptopleura ramoso, a red seaweed from the South American coasts. The compound was a selective inhibitor of HSV-1 and HSV-2 replication in Vero cells with 50% inhibitory concentrations (IC 50 ,) in the range 1.6 - 4.2μg/ml and a 50% cytotoxic concentration (CC 50 )) of 476 μg/ml. SG was also effective against HSV-1 in cells of neural origin such as murine astrocytes. The mode of action of SG could be ascribed to an inhibitory action on virus adsorption. Furthermore, SG did not inhibit the blood coagulation process at concentrations highly exceeding the IC 50 .

Registro:

Documento: Artículo
Título:Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture
Autor:Carlucci, M.J.; Scolaro, L.A.; Errea, M.I.; Matulewicz, M.C.; Damonte, E.B.
Filiación:Laboratorio de Virología, Depto. de Quim. Biológica, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:Cryptopleura ramosa; Delesseriaceae; Herpes simplex virus; Natural antiviral; Red seaweed; Sulphated polisaccharide; cryptopleura romosa extract; galactan; plant extract; unclassified drug; anticoagulation; antiviral activity; article; cytotoxicity; drug isolation; herpes simplex virus; nonhuman; virus adsorption; virus replication; Algae, Red; Animals; Antiviral Agents; Astrocytes; Cell Survival; Cells, Cultured; Cercopithecus aethiops; Galactans; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Mice; Plants, Medicinal; Seawater; Vero Cells; Virus Replication; algae; Cryptopleura; Cryptopleura ramosa; Delesseriaceae; Herpes; Herpesviridae; Human herpesvirus 1; Human herpesvirus 2; Murinae; Simplexvirus
Año:1997
Volumen:63
Número:5
Página de inicio:429
Página de fin:432
DOI: http://dx.doi.org/10.1055/s-2006-957727
Título revista:Planta Medica
Título revista abreviado:PLANTA MED.
ISSN:00320943
CODEN:PLMEA
CAS:Antiviral Agents; Galactans
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v63_n5_p429_Carlucci

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Citas:

---------- APA ----------
Carlucci, M.J., Scolaro, L.A., Errea, M.I., Matulewicz, M.C. & Damonte, E.B. (1997) . Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture. Planta Medica, 63(5), 429-432.
http://dx.doi.org/10.1055/s-2006-957727
---------- CHICAGO ----------
Carlucci, M.J., Scolaro, L.A., Errea, M.I., Matulewicz, M.C., Damonte, E.B. "Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture" . Planta Medica 63, no. 5 (1997) : 429-432.
http://dx.doi.org/10.1055/s-2006-957727
---------- MLA ----------
Carlucci, M.J., Scolaro, L.A., Errea, M.I., Matulewicz, M.C., Damonte, E.B. "Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture" . Planta Medica, vol. 63, no. 5, 1997, pp. 429-432.
http://dx.doi.org/10.1055/s-2006-957727
---------- VANCOUVER ----------
Carlucci, M.J., Scolaro, L.A., Errea, M.I., Matulewicz, M.C., Damonte, E.B. Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture. PLANTA MED. 1997;63(5):429-432.
http://dx.doi.org/10.1055/s-2006-957727