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Abstract:

In this study we tested whether periodic maternal deprivation (MD) (4.5 h daily during the first 3 weeks of life) caused chronic changes in anxiety and medullo-adrenal responses to chronic stress in either male or female adult (2.5 months of age) rats, or both. Repeated maternal deprivation had a sex-specific effect on epinephrine (E) and norepinephrine (NE) levels: an increase in both measures was observed only in females. Unpredictable stress did not produce changes on plasma catecholamine levels either in males or females. However, when the females were maternally deprived as well as stressed they showed an increase in plasma NE p < 0.05. On the other hand, non-maternally deprived (NMD), maternally-deprived and stressed males showed high levels of catecholamines compared to females p < 0.001. In the elevated plus maze test, MD-treated males displayed a slight increase in anxiety-related behavior compared with NMD rats. This was indicated by a reduction in the time spent on the open arms, whereas females showed less anxiety, indicated by an increase in the number of entries, and in the time spent on the open arms. After exposure to chronic stress only the females displayed decreased anxiety-related behavior. These results suggest that there are sex-induced effects in emotional reactivity, perception of the stressor and in the evaluation of novel situations. Thus, maternal deprivation and chronic variable stress caused both long-term alterations in sympathetic response and gender-dependent changes in the anxiety index of adult rats. © 2005 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety
Autor:Renard, G.M.; Suárez, M.M.; Levin, G.M.; Rivarola, M.A.
Filiación:Cátedra de Fisiología Animal, Facultad de Ciencias Exactas Físicas Y Naturales, Universidad Nacional de Córdoba, Av. Velez Sarsfield 299, X5000JJC - Córdoba, Argentina
Centro de Investigaciones Endocrinológicas (CEDIE-CONICET), Hospital de Niños R. Gutierrez, Gallo 1330, Buenos Aires 1425, Argentina
Idioma: Inglés
Palabras clave:Anxiety; Epinephrine; Functional sex differences; Maternal deprivation; Norepinephrine; Stress; adrenalin; noradrenalin; adrenergic system; animal behavior; animal experiment; animal model; anxiety; article; controlled study; female; male; maze test; medulla oblongata; nonhuman; prediction; priority journal; rat; separation anxiety; sex difference; stress; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Epinephrine; Female; Male; Maternal Deprivation; Maze Learning; Norepinephrine; Rats; Rats, Wistar; Sex Characteristics; Sex Factors; Stress; Time Factors
Año:2005
Volumen:85
Número:3
Página de inicio:363
Página de fin:369
DOI: http://dx.doi.org/10.1016/j.physbeh.2005.05.003
Título revista:Physiology and Behavior
Título revista abreviado:Physiol. Behav.
ISSN:00319384
CODEN:PHBHA
CAS:adrenalin, 51-43-4, 55-31-2, 6912-68-1; noradrenalin, 1407-84-7, 51-41-2; Epinephrine, 51-43-4; Norepinephrine, 51-41-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319384_v85_n3_p363_Renard

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Citas:

---------- APA ----------
Renard, G.M., Suárez, M.M., Levin, G.M. & Rivarola, M.A. (2005) . Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety. Physiology and Behavior, 85(3), 363-369.
http://dx.doi.org/10.1016/j.physbeh.2005.05.003
---------- CHICAGO ----------
Renard, G.M., Suárez, M.M., Levin, G.M., Rivarola, M.A. "Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety" . Physiology and Behavior 85, no. 3 (2005) : 363-369.
http://dx.doi.org/10.1016/j.physbeh.2005.05.003
---------- MLA ----------
Renard, G.M., Suárez, M.M., Levin, G.M., Rivarola, M.A. "Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety" . Physiology and Behavior, vol. 85, no. 3, 2005, pp. 363-369.
http://dx.doi.org/10.1016/j.physbeh.2005.05.003
---------- VANCOUVER ----------
Renard, G.M., Suárez, M.M., Levin, G.M., Rivarola, M.A. Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety. Physiol. Behav. 2005;85(3):363-369.
http://dx.doi.org/10.1016/j.physbeh.2005.05.003