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Abstract:

Malnutrition is a worldwide problem affecting millions of unborn and young children during the most vulnerable stages of their development. In humans, poor maternal nutrition is a major cause of intrauterine growth restriction which is associated with an increased risk of perinatal mortality and long-term morbidity. In addition, intrauterine growth restriction correlates with neurodevelopmental delays and alterations of brain structure and neurochemistry. While there is no doubt that maternal malnutrition is a principal cause of perturbed development of the fetal brain and that all nutrients have certain influence on brain maturation, proteins appear to be the most critical for the development of neurological functions. In the present study we assessed male and female mouse offspring, born to dams protein restricted during pregnancy and lactation, in physical growth and neurobehavioral development and also in social interaction, motivation, anxiety and depressive behaviors. Moreover, we evaluate the impact of the low protein diet on dams in relation to their maternal care and anxiety-related behavior given that these clearly affect pups development. We observed that maternal protein restriction during pregnancy and lactation delayed the physical growth and neurodevelopment of the offspring in a sex-independent manner. In addition, maternal undernutrition negatively affected offspring's juvenile social play, motivation, exploratory activity and risk assessment behaviors. These findings show that protein restriction during critical periods of development detrimentally program progeny behavior. © 2014 Elsevier Inc.

Registro:

Documento: Artículo
Título:Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors
Autor:Belluscio, L.M.; Berardino, B.G.; Ferroni, N.M.; Ceruti, J.M.; Cánepa, E.T.
Filiación:Laboratorio de Biología Molecular, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón II, 1428 Ciudad de Buenos Aires, Argentina
Palabras clave:Anxiety-related behavior; Depressive-related behavior; Maternal care; Neurodevelopment; Perinatal protein malnutrition; Social behavior; animal experiment; anxiety disorder; article; controlled study; depression; exploratory behavior; female; growth; lactation; male; malnutrition; maternal care; motivation; mouse; nervous system development; nonhuman; play; pregnancy; priority journal; protein restriction; reflex; risk assessment; social interaction; animal; animal behavior; anxiety; complication; decision making; depression; etiology; inbred mouse strain; maternal behavior; maternal nutrition; physiology; prenatal exposure; protein calorie malnutrition; risk; sex difference; social behavior; Animals; Anxiety; Behavior, Animal; Decision Making; Depression; Exploratory Behavior; Female; Growth; Lactation; Male; Maternal Behavior; Maternal Nutritional Physiological Phenomena; Mice, Inbred Strains; Motivation; Pregnancy; Prenatal Exposure Delayed Effects; Protein-Energy Malnutrition; Reflex; Risk; Sex Factors; Social Behavior
Año:2014
Volumen:129
Página de inicio:237
Página de fin:254
DOI: http://dx.doi.org/10.1016/j.physbeh.2014.02.051
Título revista:Physiology and Behavior
Título revista abreviado:Physiol. Behav.
ISSN:00319384
CODEN:PHBHA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319384_v129_n_p237_Belluscio

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Citas:

---------- APA ----------
Belluscio, L.M., Berardino, B.G., Ferroni, N.M., Ceruti, J.M. & Cánepa, E.T. (2014) . Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors. Physiology and Behavior, 129, 237-254.
http://dx.doi.org/10.1016/j.physbeh.2014.02.051
---------- CHICAGO ----------
Belluscio, L.M., Berardino, B.G., Ferroni, N.M., Ceruti, J.M., Cánepa, E.T. "Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors" . Physiology and Behavior 129 (2014) : 237-254.
http://dx.doi.org/10.1016/j.physbeh.2014.02.051
---------- MLA ----------
Belluscio, L.M., Berardino, B.G., Ferroni, N.M., Ceruti, J.M., Cánepa, E.T. "Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors" . Physiology and Behavior, vol. 129, 2014, pp. 237-254.
http://dx.doi.org/10.1016/j.physbeh.2014.02.051
---------- VANCOUVER ----------
Belluscio, L.M., Berardino, B.G., Ferroni, N.M., Ceruti, J.M., Cánepa, E.T. Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors. Physiol. Behav. 2014;129:237-254.
http://dx.doi.org/10.1016/j.physbeh.2014.02.051