Artículo

La versión final de este artículo es de uso interno. El editor solo permite incluir en el repositorio el artículo en su versión post-print. Por favor, si usted la posee enviela a
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Conspicuous and sustained heart arrests, revealed as an increase in the magnitude of cardiac interbeat intervals, are elicited in the crab Neohelice granulata upon the presentation of a visual danger stimulus (VDS). Aiming to study the regulation of cardio-inhibitory responses (CIR) in vivo, we investigated whether GABA mediates the extrinsic regulation of the cardiac activity. We examined the possibility of abolishing CIR by injecting the GABAergic antagonists picrotoxin and bicuculline, right before sensory stimulation. Picrotoxin partially abolished the reversible cardiac arrests induced by VDS, whereas bicuculline showed no effects. These results suggest that the rapid responses of the cardiac system of the crab Neohelice to environmental disturbances, reminiscent of an autonomic-like regulation associated with fear, flight or fight, may be extrinsically regulated by the GABAergic system. © 2012 Elsevier Inc.

Registro:

Documento: Artículo
Título:Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
Autor:Yang, M.; Carbó Tano, M.; Hermitte, G.
Filiación:Laboratorio de Neurobiología de la Memoria, IFIByNE-CONICET, Departamento de Fisiología Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pab. II, (C1428EHA), Buenos Aires, Argentina
Palabras clave:Autonomic system; Cardiac response; GABA; Heart arrest; Invertebrate; 4 aminobutyric acid; bicuculline; picrotoxin; animal experiment; animal model; article; bradycardia; cardioinhibitory response; controlled study; crab; heart arrest; heart beat; heart contraction; heart function; heart rate; in vivo study; male; nonhuman; priority journal; visual stimulation
Año:2013
Volumen:110-111
Página de inicio:198
Página de fin:205
DOI: http://dx.doi.org/10.1016/j.physbeh.2012.12.013
Título revista:Physiology and Behavior
Título revista abreviado:Physiol. Behav.
ISSN:00319384
CODEN:PHBHA
CAS:4 aminobutyric acid, 28805-76-7, 56-12-2; bicuculline, 485-49-4; picrotoxin, 124-87-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319384_v110-111_n_p198_Yang

Referencias:

  • Alexandrowicz, J.S., The innervation of the heart of Crustacea. I. Decapoda (1932) Q J Microsc Sci, 75, pp. 181-249
  • Ando, H., Kuwasawa, K., Neuronal and neurohormonal control of the heart in the stomatopod crustacean, Squilla oratoria (2004) J Exp Biol, 207, pp. 4663-4677
  • Axelsson, M., Abe, A.S., Bicudo, J.E.P.W., Nilsson, S., On the cardiac control in the South American lungfish, Lepidosiren paradoxa (1989) Comp Biochem Physiol, 93 A, pp. 561-565
  • Axelsson, M., Ehrenstrom, F., Nilsson, S., Cholinergic and adrenergic influence on the teleost heart in vivo (1987) J Exp Biol, 46, pp. 179-186
  • Benson, J.A., Bicuculline blocks the response to acetylcholine and nicotine but not to muscarine or GABA in isolated insect neuronal somata (1988) Brain Res, 458, pp. 65-71
  • Benson, J.A., A novel GABA receptor in the heart of a primitive arthropod, Limulus polyphemus (1989) J Exp Biol, 147, pp. 421-438
  • Burnovicz, A., Hermitte, G., Conditioning of an autonomic response in Crustacea (2010) Physiol Behav, 101, pp. 168-175
  • Burnovicz, A., Oliva, D., Hermitte, G., The cardiac response of the crab Chasmagnathus granulatus as an index of sensory perception (2009) J Exp Biol, 212, pp. 313-324
  • Cameron, J.S., Autonomic nervous tone and regulation of heart rate in the goldfish, Carassius auratus (1979) Comp Biochem Physiol C, 63, pp. 341-349
  • Carbo Tano, M., Molina, V.A., Maldonado, H., Pedreira, M.E., Memory consoloditation and reconsolidation in an invertebrate model: the role of the GABAergic system (2009) Neuroscience, 158, pp. 387-401
  • Cohen, D.H., Macdonald, R.L., Some variables affecting orienting and conditioned heart-rate responses in the pigeon (1971) J Comp Physiol Psychol, 74, pp. 123-133
  • Cooke, I.M., (1962) The neurohumoral regulation of the crustacean heart, , Harvard University
  • Cruz-Bermudez, N.D., Marder, E., Multiple modulators act on the cardiac ganglion of the crab, Cancer borealis (2007) J Exp Biol, 210, pp. 2873-2884
  • Cuadras, J., Cardiac responses to visual detection of movement, mechanostimulation and cheliped imposed movement in hermit crabs (1980) Comp Biochem Physiol A Mol Integr Physiol, 66, pp. 113-117
  • Cuadras, J., Behavioral determinants of severe cardiac inhibition (1981) J Comp Physiol Psychol, 9, pp. 384-392
  • Davis, M., The role of the amygdala in conditioned fear (1992) The amygdala: neurobiological aspects of emotion, memory, and mental dysfunction, pp. 255-305. , Wiley-Liss, New York, J.P. Appleton (Ed.)
  • Delgado, J.Y., Oyola, E., Miller, M.W., Localization of GABA- and glutamate-like immunoreactivity in the cardiac ganglion of the lobster Panulirus argus (2000) J Neurocytol, 29, pp. 605-619
  • Field, L.H., Larimer, J.L., The cardioregulatory system of crayfish: neuroanatomy and physiology (1975) J Exp Biol, 62, pp. 519-530
  • Florey, E., Studies on the nervous regulation of the heart beat in decapod Crustacea (1960) J Gen Physiol, pp. 1061-1081
  • Fort, T.J., Brezina, V., Miller, M.W., Modulation of an integrated central pattern generator-effector system: dopaminergic regulation of cardiac activity in the blue crab Callinectes sapidus (2004) J Neurophysiol, 92, pp. 3455-3470
  • Freschi, J.E., Livengood, D.R., Membrane current underlying muscarinic cholinergic excitation of motoneurons in lobster cardiac ganglion (1989) J Neurophysiol, 62, pp. 984-995
  • Graham, F.K., Clifton, R.K., Heart-rate change as a component of the orienting response (1966) Psychol Bull, 65, pp. 305-320
  • Grober, M.S., Luminescent flash avoidance in the nocturnal crab Portunus xantussii. I. The effects of luminescence and mechanical stimulation on heart rate (1990) J Exp Biol, 148, pp. 415-426
  • Guirguis, M.S., Wilkens, J.L., The role of the cardioregulatory nerves in mediating heart rate responses to locomotion, reduced stroke volume, and neurohormones in Homarus americanus (1995) Biol Bull, 188, pp. 179-185
  • Hermitte, G., Maldonado, H., Cardiovascular component of the context signal memory in the crab Chasmagnathus (2006) J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 192, pp. 69-83
  • Hoeger, U., Florey, E., Catecholamine degradation in the hemolymph of the Chinese crab, Eriocheir sinensis (1989) Comp Biochem Physiol C, 91, pp. 323-327
  • Holden-Dye, L., Hewitt, G.M., Wann, K.T., Krogsgaard-Larsen, P., Walker, R.J., Studies involving avermectin and the 4-animobutyric acid receptor of Ascaris suum muscle (1988) J Pestic Sci, 24, pp. 231-245
  • Ide, L.M., Hoffmann, A., Stressful and behavioral conditions that affect reversible cardiac arrest in the Nile tilapia, Oreochromis niloticus (Teleostei) (2002) Physiol Behav, 75, pp. 119-126
  • Kerrison, J., Freschi, J.E., The effects of gamma-aminobutyric acid on voltage-clamped motoneurons of the lobster cardiac ganglion (1992) Comp Biochem Physiol C Toxicol Pharmacol, 101, pp. 227-233
  • King, A.J., Adamo, S.A., The ventilatory, cardiac and behavioural responses of resting cuttlefish (Sepia officinalis L.) to sudden visual stimuli (2006) J Exp Biol, 209, pp. 1101-1111
  • Lacey, B.C., Lacey, J.I., Studies of heart rate and other bodily processes in sensorimotor behavior (1974) Cardiovascular psychophysiology: current issues in response mechanisms, biofeedback, and methodology, pp. 538-564. , Adline Press, Chicago, P.A. Obrist, A.H. Black, J. Brener, L.V. DiCara (Eds.)
  • Laming, P.R., The physiological basis of alert behaviour in fish (1981) Brain mechanisms of behaviour in lower vertebrates, pp. 203-224. , Cambridge University Press, Cambridge, England, P.R. Laming (Ed.)
  • Laming, P.R., Austin, M., Cardiac responses of the anurans, Bufo bufo and Rana pipiens, during behavioural arousal and fright (1981) Comp Biochem Physiol A Physiol, 68, pp. 515-518
  • Laming, P.R., Savage, G.E., Physiological changes observed in the goldfish (Carassius auratus) during behavioral arousal and fright (1980) Behav Neural Biol, 29, pp. 255-275
  • LeDoux, J.E., Emotional memory systems in the brain (1993) Behav Brain Res, 58, pp. 69-79
  • Lees, G., Beadle, D.J., Neumann, R., Benson, J.A., Responses to GABA by isolated insect neuronal somata: pharmacology and modulation by a benzodiazepine and barbiturate (1987) Brain Res, 401, pp. 267-278
  • Li, H., Listerman, L.R., Doshi, D., Cooper, R.L., Heart rate measures in blind cave crayfish during environmental disturbances and social interactions (2000) Comp Biochem Physiol A Mol Integr Physiol, 127, pp. 55-70
  • Listerman, L.R., Deskins, J., Bradacs, H., Cooper, R.L., Heart rate within male crayfish: social interactions and effects of 5-HT (2000) Comp Biochem Physiol A Mol Integr Physiol, 125, pp. 251-263
  • Maynard, D.M., Activity in a crustacean ganglion. I. Cardioinhibition and acceleration in Panilurus argus (1953) Biol Bull, 109, pp. 420-436
  • Maynard, D.M., Cardiac inhibition in decapod Crustacea (1961) Nervous inhibition, pp. 144-178. , Pergamon Press, Oxford, London, New York, Paris, E. Florey (Ed.)
  • McMahon, B.R., Wilkens, J.L., Simultaneous apnoea and bradycardia in the lobster Homarus americanus (1972) Can J Zool, 50, pp. 165-170
  • Miyata, H., Nagayama, T., Takahata, M., Two types of indentified ascending interneurons with distinc GABA receptors in the crayfish terminal abdominal ganglion (1997) J Neurophysiol, 77, pp. 1213-1223
  • Mott, J.C., Some factors affecting the blood circulation in the common eel (Anguilla anguilla) (1951) J Physiol, 114, pp. 387-398
  • Powell, D.A., Rapid associative learning: conditioned bradycardia and its central nervous system substrates (1994) Integr Physiol Behav Sci, 29, pp. 109-133
  • Sattelle, D.B., GABA receptors of insects (1990) Adv Insect Physiol, 22, pp. 1-113
  • Schapker, H., Breithaupt, T., Shuranova, Z., Burmistrov, Y., Cooper, R.L., Heart and ventilatory measures in crayfish during environmental disturbances and social interactions (2002) Comp Biochem Physiol A Mol Integr Physiol, 131, pp. 397-407
  • Shimahara, T., The inhibitory post-synaptic potential in the cardiac ganglion cell of the lobster (1969) Panulirus Japonicus Sci Rep Tokyo Kyoiku Daigaku, 14 B, pp. 9-26
  • Shuranova, Z.P., Burmistrov, Y.M., Orienting reaction in invertebrates (1996) Neurosci Behav Physiol, 26, pp. 406-415
  • Shuranova, Z.P., Burmistrov, Y.M., Strawn, J.R., Cooper, R.L., Evidence for an autonomic nervous system in decapod crustaceans (2006) Int J Zool Res, 3, pp. 1-33
  • Smith, E.N., Johnson, C., Martin, K.J., Fear RCA in captive eastern chipmunk, Tamias striatus (1981) Comp Biochem Physiol, 70 A, pp. 529-532
  • Smith, E.N., Woodruff, R.A., Fear bradycardia in free ranging woodchucks, Marmota monax (1980) J Mammal, 61, pp. 750-753
  • Strawn, J.R., Neckameyer, W.S., Cooper, R.L., The effects of 5-HT on sensory neurons, CNS command, and neuromuscular junctions of the crayfish abdominal superficial flexor (2000) Comp Biochem Physiol B, 127, pp. 533-550
  • Sullivan, R.E., Miller, M.W., Cholinergic activation of the lobster cardiac ganglion (1990) J Neurobiol, 21, pp. 639-650
  • Tanaka, K., Yazawa, T., Kuwasawa, K., Cholinergic and GABAergic control of the heart in the isopod crustacean, Bathynomus doederleini (1992) Phylogenetic models in functional coupling of the CNS and the cardiovascular system, comparative physiology, pp. 132-140. , Karger, Basel, R.B. Hill, K. Kuwasawa, R.R. McMahon, T. Kuramoto (Eds.)
  • Wann, K.T., The electrophysiology of the somatic muscle cells of Ascaris suum (1987) Parasitology, 94, pp. 555-566
  • Wells, M.J., The heartbeat of Octopus vulgaris (1979) J Exp Biol, 78, pp. 87-104
  • Wilkens, J.L., Mercier, A.J., Evans, J., Cardiac and ventilatory responses to stress and to neurohormonal modulation by the shore crab Carcinus maenas (1985) Comp Biochem Physiol C, 82, pp. 337-343
  • Wilkens, J.L., Walker, R.L., Nervous control of crayfish cardiac hemodynamics (1992) J Comp Physiol, pp. 115-122
  • Yang, M., Carbó Tano, M., Freudenthal, R., Hermitte, G., Characterization of the cardiac ganglion in the crab Neohelice granulata and immunohistochemical evidence of GABA-like extrinsic regulation (2013) Arthropod Struct Dev, 42, pp. 17-25
  • Yazawa, T., Kuwasawa, K., Intrinsic and extrinsic neural and neurohumoral control of the decapod heart (1992) J Cell Mol Life Sci, 48, pp. 834-840
  • Yazawa, T., Kuwasawa, K., Dopaminergic acceleration and GABAergic inhibition in extrinsic neural control of the hermit crab heart (1994) J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 174, pp. 65-75
  • Young, R.E., Correlated activities in the cardioregulator nerves and ventilatory system in the Norwegian lobster, Nephrops norvegicus (L.) (1978) Comp Biochem Physiol A Physiol, pp. 387-394

Citas:

---------- APA ----------
Yang, M., Carbó Tano, M. & Hermitte, G. (2013) . Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata. Physiology and Behavior, 110-111, 198-205.
http://dx.doi.org/10.1016/j.physbeh.2012.12.013
---------- CHICAGO ----------
Yang, M., Carbó Tano, M., Hermitte, G. "Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata" . Physiology and Behavior 110-111 (2013) : 198-205.
http://dx.doi.org/10.1016/j.physbeh.2012.12.013
---------- MLA ----------
Yang, M., Carbó Tano, M., Hermitte, G. "Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata" . Physiology and Behavior, vol. 110-111, 2013, pp. 198-205.
http://dx.doi.org/10.1016/j.physbeh.2012.12.013
---------- VANCOUVER ----------
Yang, M., Carbó Tano, M., Hermitte, G. Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata. Physiol. Behav. 2013;110-111:198-205.
http://dx.doi.org/10.1016/j.physbeh.2012.12.013