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Abstract:

The anterior pituitary gland has the ability to respond to complex signals derived from central and peripheral systems. Perception of these signals and their integration are mediated by cell interactions and cross-talk of multiple signaling transduction pathways and transcriptional regulatory networks that cooperate for hormone secretion, cell plasticity, and ultimately specific pituitary responses that are essential for an appropriate physiological response. We discuss the physiopathological and molecular mechanisms related to this integrative regulatory system of the anterior pituitary gland and how it contributes to modulate the gland functions and impacts on body homeostasis. © 2012 by the American Physiological Society.

Registro:

Documento: Artículo
Título:Cellular and molecular specificity of pituitary gland physiology
Autor:Perez-Castro, C.; Renner, U.; Haedo, M.R.; Stalla, G.K.; Arzt, E.
Filiación:Laboratorio de Regulación de la Expresión Génica en el Crecimiento, Departamento de Quimica Biologica, Departamento de Fisiologia y Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Max Planck Institute of Psychiatry, Department of Endocrinology, Munich, Germany
Instituto de Investigación Biomedicina de Buenos Aires (IBioBA), CONICET, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Palabras clave:activin; bone morphogenetic protein; dopamine receptor stimulating agent; epidermal growth factor receptor; estradiol; gonadotropin; Notch receptor; prolactin; retinoid; transcription factor Sox; transforming growth factor beta; ACTH secreting cell; adenohypophysis; adenoma; article; breast cancer; cell communication; cell growth; cell interaction; cell specificity; cell type; endocrine cell; endothelium cell; growth regulation; homeostasis; hormone release; human; hypophysis; hypophysis cell; hypophysis tumor; lung cancer; microglia; molecular biology; negative feedback; neovascularization (pathology); neurohypophysis; nonhuman; oncogene; paracrine signaling; perception; peripheral nervous system; plasmacytoid dendritic cell; positive feedback; priority journal; prolactin secreting cell; prolactinoma; protein expression; regulatory mechanism; senescence; TSH secreting cell
Año:2012
Volumen:92
Número:1
Página de inicio:1
Página de fin:38
DOI: http://dx.doi.org/10.1152/physrev.00003.2011
Título revista:Physiological Reviews
Título revista abreviado:Physiol. Rev.
ISSN:00319333
CODEN:PHREA
CAS:activin, 114949-22-3; epidermal growth factor receptor, 79079-06-4; estradiol, 50-28-2; gonadotropin, 63231-54-9; prolactin, 12585-34-1, 50647-00-2, 9002-62-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319333_v92_n1_p1_PerezCastro

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Citas:

---------- APA ----------
Perez-Castro, C., Renner, U., Haedo, M.R., Stalla, G.K. & Arzt, E. (2012) . Cellular and molecular specificity of pituitary gland physiology. Physiological Reviews, 92(1), 1-38.
http://dx.doi.org/10.1152/physrev.00003.2011
---------- CHICAGO ----------
Perez-Castro, C., Renner, U., Haedo, M.R., Stalla, G.K., Arzt, E. "Cellular and molecular specificity of pituitary gland physiology" . Physiological Reviews 92, no. 1 (2012) : 1-38.
http://dx.doi.org/10.1152/physrev.00003.2011
---------- MLA ----------
Perez-Castro, C., Renner, U., Haedo, M.R., Stalla, G.K., Arzt, E. "Cellular and molecular specificity of pituitary gland physiology" . Physiological Reviews, vol. 92, no. 1, 2012, pp. 1-38.
http://dx.doi.org/10.1152/physrev.00003.2011
---------- VANCOUVER ----------
Perez-Castro, C., Renner, U., Haedo, M.R., Stalla, G.K., Arzt, E. Cellular and molecular specificity of pituitary gland physiology. Physiol. Rev. 2012;92(1):1-38.
http://dx.doi.org/10.1152/physrev.00003.2011