Artículo

González, S.J.; Pozzi, E.C.C.; Monti Hughes, A.; Provenzano, L.; Koivunoro, H.; Carando, D.G.; Thorp, S.I.; Casal, M.R.; Bortolussi, S.; Trivillin, V.A.; Garabalino, M.A.; Curotto, P.; Heber, E.M.; Santa Cruz, G.A.; Kankaanranta, L.; Joensuu, H.; Schwint, A.E. "Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer" (2017) Physics in Medicine and Biology. 62(20):7938-7958
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Abstract:

Boron neutron capture therapy (BNCT) is a treatment modality that combines different radiation qualities. Since the severity of biological damage following irradiation depends on the radiation type, a quantity different from absorbed dose is required to explain the effects observed in the clinical BNCT in terms of outcome compared with conventional photon radiation therapy. A new approach for calculating photon iso-effective doses in BNCT was introduced previously. The present work extends this model to include information from dose-response assessments in animal models and humans. Parameters of the model were determined for tumour and precancerous tissue using dose-response curves obtained from BNCT and photon studies performed in the hamster cheek pouch in vivo models of oral cancer and/or pre-cancer, and from head and neck cancer radiotherapy data with photons. To this end, suitable expressions of the dose-limiting Normal Tissue Complication and Tumour Control Probabilities for the reference radiation and for the mixed field BNCT radiation were developed. Pearson's correlation coefficients and p-values showed that TCP and NTCP models agreed with experimental data (with r > 0.87 and p-values >0.57). The photon iso-effective dose model was applied retrospectively to evaluate the dosimetry in tumours and mucosa for head and neck cancer patients treated with BNCT in Finland. Photon iso-effective doses in tumour were lower than those obtained with the standard RBE-weighted model (between 10% to 45%). The results also suggested that the probabilities of tumour control derived from photon iso-effective doses are more adequate to explain the clinical responses than those obtained with the RBE-weighted values. The dosimetry in the mucosa revealed that the photon iso-effective doses were about 30% to 50% higher than the corresponding RBE-weighted values. While the RBE-weighted doses are unable to predict mucosa toxicity, predictions based on the proposed model are compatible with the observed clinical outcome. The extension of the photon iso-effective dose model has allowed, for the first time, the determination of the photon iso-effective dose for unacceptable complications in the dose-limiting normal tissue. Finally, the formalism developed in this work to compute photon-equivalent doses can be applied to other therapies that combine mixed radiation fields, such as hadron therapy. © 2017 Institute of Physics and Engineering in Medicine.

Registro:

Documento: Artículo
Título:Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer
Autor:González, S.J.; Pozzi, E.C.C.; Monti Hughes, A.; Provenzano, L.; Koivunoro, H.; Carando, D.G.; Thorp, S.I.; Casal, M.R.; Bortolussi, S.; Trivillin, V.A.; Garabalino, M.A.; Curotto, P.; Heber, E.M.; Santa Cruz, G.A.; Kankaanranta, L.; Joensuu, H.; Schwint, A.E.
Filiación:Subgerencia de Instrumentacion y Control and Gerencia de Investigacion y Aplicaciones No Nucleares, Centro Atómico Constituyentes, Comisión Nacional de Energía Atómica (CNEA), Av. General Paz 1499, San Martín, Buenos Aires, 1650, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Neutron Therapeutics, Helsinki, Finland
Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Departamento de Matemática, Universidad de Buenos Aires, FCEN, Buenos Aires, Argentina
Facultad de Medicina, Universidad de Buenos Aires, Instituto de Oncología Ángel Roffo, Buenos Aires, Argentina
Department of Physics, University of Pavia, National Institute of Nuclear Physics (INFN), Unit of Pavia, Pavia, Italy
Palabras clave:BNCT; hamster cheek pouch in vivo model of oral cancer; head and neck cancer; NTCP; photon iso-effective dose; TCP; Animals; Boron; Correlation methods; Diseases; Dosimetry; Patient monitoring; Patient treatment; Photons; Physiological models; Radiation; Radiation effects; Radiotherapy; Tissue; Transmission control protocol; Tumors; BNCT; Effective dose; Head-and-neck cancer; NTCP; Oral cancer; Neutron irradiation; animal; boron neutron capture therapy; disease model; hamster; head and neck tumor; human; melanoma; mouth tumor; mucosa inflammation; photon; precancer; radiometry; squamous cell carcinoma; Animals; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Head and Neck Neoplasms; Humans; Melanoma; Mouth Neoplasms; Mucositis; Photons; Precancerous Conditions; Radiometry
Año:2017
Volumen:62
Número:20
Página de inicio:7938
Página de fin:7958
DOI: http://dx.doi.org/10.1088/1361-6560/aa8986
Título revista:Physics in Medicine and Biology
Título revista abreviado:Phys. Med. Biol.
ISSN:00319155
CODEN:PHMBA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319155_v62_n20_p7938_Gonzalez

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Citas:

---------- APA ----------
González, S.J., Pozzi, E.C.C., Monti Hughes, A., Provenzano, L., Koivunoro, H., Carando, D.G., Thorp, S.I.,..., Schwint, A.E. (2017) . Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer. Physics in Medicine and Biology, 62(20), 7938-7958.
http://dx.doi.org/10.1088/1361-6560/aa8986
---------- CHICAGO ----------
González, S.J., Pozzi, E.C.C., Monti Hughes, A., Provenzano, L., Koivunoro, H., Carando, D.G., et al. "Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer" . Physics in Medicine and Biology 62, no. 20 (2017) : 7938-7958.
http://dx.doi.org/10.1088/1361-6560/aa8986
---------- MLA ----------
González, S.J., Pozzi, E.C.C., Monti Hughes, A., Provenzano, L., Koivunoro, H., Carando, D.G., et al. "Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer" . Physics in Medicine and Biology, vol. 62, no. 20, 2017, pp. 7938-7958.
http://dx.doi.org/10.1088/1361-6560/aa8986
---------- VANCOUVER ----------
González, S.J., Pozzi, E.C.C., Monti Hughes, A., Provenzano, L., Koivunoro, H., Carando, D.G., et al. Photon iso-effective dose for cancer treatment with mixed field radiation based on dose-response assessment from human and an animal model: Clinical application to boron neutron capture therapy for head and neck cancer. Phys. Med. Biol. 2017;62(20):7938-7958.
http://dx.doi.org/10.1088/1361-6560/aa8986