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Abstract:

In the present work, we have synthesized and fully characterized the photophysical and photochemical properties of a selected group of N-methyl-β-carboline derivatives (9-methyl-β-carbolines and iodine salts of 2-methyl- and 2,9-dimethyl-β-carbolinium) in aqueous solutions, in the pH range 4.0–14.5. Moreover, despite the quite extensive studies reported in the literature regarding the overall photophysical behavior of N-unsubstituted βCs, this work constitutes the first full and unambiguous characterization of anionic species of N-unsubstituted βCs (norharmane, harmane and harmine), present in aqueous solution under highly alkaline conditions (pH > 13.0). Acid dissociation constants (Ka), thermal stabilities, room temperature UV–visible absorption and fluorescence emission and excitation spectra, fluorescence quantum yields (ФF) and fluorescence lifetimes (τF), as well as quantum yields of singlet oxygen production (ФΔ) have been measured for all the studied compounds. Furthermore, for the first time to our knowledge, chemometric techniques (MCR-ALS and PARAFAC) were applied on these systems, providing relevant information about the equilibria and species involved. The impact of all the foregoing observations on the biological role, as well as the potential biotechnological applications of these compounds, is discussed. © 2017 The American Society of Photobiolog/1.

Registro:

Documento: Artículo
Título:Photophysical and Photochemical Properties of Naturally Occurring normelinonine F and Melinonine F Alkaloids and Structurally Related N(2)- and/or N(9)-methyl-β-carboline Derivatives
Autor:Rasse-Suriani, F.A.O.; García-Einschlag, F.S.; Rafti, M.; Schmidt De León, T.; David Gara, P.M.; Erra-Balsells, R.; Cabrerizo, F.M.
Filiación:Instituto de Investigaciones Biotecnológicas – Instituto Tecnológico de Chascomús (IIB-INTECH), Universidad Nacional de San Martín (UNSAM) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Chascomús, Argentina
INIFTA – CONICET, Universidad Nacional de La Plata, La Plata, Argentina
Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
Centro de Investigación en Hidratos de Carbono (CIHIDECAR - CONICET), Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
Centro de Investigaciones Ópticas (CIOP – CONICET – CIC), Universidad Nacional de La Plata, La Plata, Argentina
Año:2018
Volumen:94
Número:1
Página de inicio:36
Página de fin:51
DOI: http://dx.doi.org/10.1111/php.12811
Título revista:Photochemistry and Photobiology
Título revista abreviado:Photochem. Photobiol.
ISSN:00318655
CODEN:PHCBA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00318655_v94_n1_p36_RasseSuriani

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Citas:

---------- APA ----------
Rasse-Suriani, F.A.O., García-Einschlag, F.S., Rafti, M., Schmidt De León, T., David Gara, P.M., Erra-Balsells, R. & Cabrerizo, F.M. (2018) . Photophysical and Photochemical Properties of Naturally Occurring normelinonine F and Melinonine F Alkaloids and Structurally Related N(2)- and/or N(9)-methyl-β-carboline Derivatives. Photochemistry and Photobiology, 94(1), 36-51.
http://dx.doi.org/10.1111/php.12811
---------- CHICAGO ----------
Rasse-Suriani, F.A.O., García-Einschlag, F.S., Rafti, M., Schmidt De León, T., David Gara, P.M., Erra-Balsells, R., et al. "Photophysical and Photochemical Properties of Naturally Occurring normelinonine F and Melinonine F Alkaloids and Structurally Related N(2)- and/or N(9)-methyl-β-carboline Derivatives" . Photochemistry and Photobiology 94, no. 1 (2018) : 36-51.
http://dx.doi.org/10.1111/php.12811
---------- MLA ----------
Rasse-Suriani, F.A.O., García-Einschlag, F.S., Rafti, M., Schmidt De León, T., David Gara, P.M., Erra-Balsells, R., et al. "Photophysical and Photochemical Properties of Naturally Occurring normelinonine F and Melinonine F Alkaloids and Structurally Related N(2)- and/or N(9)-methyl-β-carboline Derivatives" . Photochemistry and Photobiology, vol. 94, no. 1, 2018, pp. 36-51.
http://dx.doi.org/10.1111/php.12811
---------- VANCOUVER ----------
Rasse-Suriani, F.A.O., García-Einschlag, F.S., Rafti, M., Schmidt De León, T., David Gara, P.M., Erra-Balsells, R., et al. Photophysical and Photochemical Properties of Naturally Occurring normelinonine F and Melinonine F Alkaloids and Structurally Related N(2)- and/or N(9)-methyl-β-carboline Derivatives. Photochem. Photobiol. 2018;94(1):36-51.
http://dx.doi.org/10.1111/php.12811