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Abstract:

The photophysical properties of lipophilic phthalocyanines encapsulated into a polymer and two different gels were studied in order to predict their photosensitizing efficacy in vivo. Photophysical techniques for solid phase were adapted for light dispersing samples. Gel formulation of two tetrasubstituted phthalocyanines, tetra-t-butylphthalocyaninato zinc(II) (1), tetrakis(1,1-dimethyl-2-phthalimido)ethylphtalocyaninatozinc(II) (2) and two octasubstituted phthalocyanines, 2,3,9,10,16,17,23,24-octakis(decyloxy) phthalocyaninatozinc(II) (3) and 2,3,9,10,16,17,23,24-octakis[(N,N- dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) (4) were investigated for their possible use in photodynamic therapy for topical purposes. Supporting the fact that gel formulation improves the photophysical properties of phthalocyanines, singlet molecular oxygen quantum yield (Pδ) values for 1-4 zinc(II) phthalocyaninates in Lutrol® F 127-Cremophor® RH 40 were 0.60, 0.60, 0.20 and 0.26, respectively. Permeation studies showed that no release of phthalocyanines occurs, thus indicating there should be no risk of generalized skin photosensitivity in areas other than the dye-deposition site.

Registro:

Documento: Artículo
Título:Photophysics of zinc (II) phthalocyanine polymer and gel formulation
Autor:Rodriguez, M.E.; Diz, V.E.; Awruch, J.; Dicelio, L.E.
Filiación:INQUIMAE, Departamento de Química Inorgánica, Analítica y Química Fisica, Universidad de Buenos Aires, Buenos Aires, Argentina
Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, United States
Palabras clave:indole derivative; photosensitizing agent; phthalocyanine; polymer; singlet oxygen; zinc; gel; indole derivative; microcapsule; polymer; article; chemistry; gel; methodology; microcapsule; permeability; photochemistry; photochemotherapy; radiation exposure; chemistry; gel; procedures; radiation response; Capsules; Gels; Indoles; Permeability; Photochemical Processes; Photochemotherapy; Photosensitizing Agents; Polymers; Singlet Oxygen; Zinc; Tetra; Capsules; Gels; Indoles; Permeability; Photochemical Processes; Photochemotherapy; Photosensitizing Agents; Polymers; Singlet Oxygen; Zinc
Año:2010
Volumen:86
Número:3
Página de inicio:513
Página de fin:519
DOI: http://dx.doi.org/10.1111/j.1751-1097.2009.00702.x
Título revista:Photochemistry and Photobiology
Título revista abreviado:Photochem. Photobiol.
ISSN:00318655
CODEN:PHCBA
CAS:phthalocyanine, 574-93-6; zinc, 14378-32-6, 7440-66-6; zinc, 7440-66-6, 14378-32-6; Capsules; Gels; Indoles; Photosensitizing Agents; Polymers; Singlet Oxygen, 17778-80-2; Zinc, 7440-66-6; phthalocyanine, 574-93-6; Capsules; Gels; Indoles; Photosensitizing Agents; phthalocyanine; Polymers; Singlet Oxygen; Zinc
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00318655_v86_n3_p513_Rodriguez

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Citas:

---------- APA ----------
Rodriguez, M.E., Diz, V.E., Awruch, J. & Dicelio, L.E. (2010) . Photophysics of zinc (II) phthalocyanine polymer and gel formulation. Photochemistry and Photobiology, 86(3), 513-519.
http://dx.doi.org/10.1111/j.1751-1097.2009.00702.x
---------- CHICAGO ----------
Rodriguez, M.E., Diz, V.E., Awruch, J., Dicelio, L.E. "Photophysics of zinc (II) phthalocyanine polymer and gel formulation" . Photochemistry and Photobiology 86, no. 3 (2010) : 513-519.
http://dx.doi.org/10.1111/j.1751-1097.2009.00702.x
---------- MLA ----------
Rodriguez, M.E., Diz, V.E., Awruch, J., Dicelio, L.E. "Photophysics of zinc (II) phthalocyanine polymer and gel formulation" . Photochemistry and Photobiology, vol. 86, no. 3, 2010, pp. 513-519.
http://dx.doi.org/10.1111/j.1751-1097.2009.00702.x
---------- VANCOUVER ----------
Rodriguez, M.E., Diz, V.E., Awruch, J., Dicelio, L.E. Photophysics of zinc (II) phthalocyanine polymer and gel formulation. Photochem. Photobiol. 2010;86(3):513-519.
http://dx.doi.org/10.1111/j.1751-1097.2009.00702.x