Artículo
Abstract:
Contractile response to exogenous prostaglandin E2 (PGE2) was studied in auricles from normal and acutely-diabetic (streptozotocin-treated) rats. In normal atria, PGE2 induced a biphasic inotropic effect negative at low concentrations and positive at higher ones. In diabetic, PGE2 only elicited a positive inotropic action which was greater in efficacy and potency than in normal controls. Incubation of diabetic atrial preparations with α-adrenoceptor antagonists (phentolamine, phenoxybenzamine or Prazosin) diminished the prostaglandin effect. However, blockade of β-adrenoceptors with propranolol did not modify the response. Blockers of arachidonic acid metabolism via cyclo-oxygenase (indomethacin and acetylsalicylic acid) or via lipoxygenase(s) (nordihydroguaiaretic acid and dithizone) were able to reduce the positive inotropism of PGE2. A significant blockade of the stimulant action of PGE2 was seen in the presence of inhibitors of thromboxane synthesis (L-8027 and imidazole). These results suggest that in diabetic atria PGE2 effect could be associated to an involvement of cardiac α-adrenergic stimulation which promotes endogenous arachidonic acid release with diversification of its metabolism towards cyclo- and lipoxygenase(s)- pathway and direct to an increased thromboxane formation which could account for the positive inotropic effect induced by PGE2. © 1986.
Registro:
| Documento: | Artículo |
| Título: | Increase in atrial contractility induced by PGE2 in diabetic rats |
| Autor: | Canga, L.; Sterin-Borda, L. |
| Filiación: | Centro de Estudios Farmacologicos y de Principios Naturales (CEFAPRIN)-CONICET. Serrano 665/669, 1414 Buenos Aires, Argentina |
| Palabras clave: | acetylsalicylic acid; alpha adrenergic receptor; dithizone; indometacin; nordihydroguaiaretic acid; phenoxybenzamine; phentolamine; prazosin; propranolol; prostaglandin e2; streptozocin; animal cell; animal experiment; arachidonic acid metabolism; drug efficacy; endocrine system; heart; heart atrium; heart muscle; heart muscle contractility; intravenous drug administration; nonhuman; priority journal; rat; streptozocin diabetes; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animal; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Dinoprostone; In Vitro; Lipoxygenase Inhibitors; Male; Myocardial Contraction; Prostaglandins E; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Thromboxane-A Synthase |
| Año: | 1986 |
| Volumen: | 18 |
| Número: | 4 |
| Página de inicio: | 371 |
| Página de fin: | 384 |
| DOI: | http://dx.doi.org/10.1016/0031-6989(86)90090-1 |
| Título revista: | Pharmacological Research Communications |
| Título revista abreviado: | Pharmacol. Res. Commun. |
| ISSN: | 00316989 |
| CODEN: | PLRCA |
| CAS: | acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; dithizone, 60-10-6; indometacin, 53-86-1, 74252-25-8, 7681-54-1; nordihydroguaiaretic acid, 500-38-9; phenoxybenzamine, 59-96-1, 63-92-3; phentolamine, 50-60-2, 73-05-2; prazosin, 19216-56-9, 19237-84-4; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; prostaglandin E2, 363-24-6; streptozocin, 18883-66-4; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Arachidonic Acid, 506-32-1; Arachidonic Acids; Cyclooxygenase Inhibitors; Dinoprostone, 363-24-6; Lipoxygenase Inhibitors; Prostaglandins E; Thromboxane-A Synthase, EC 5.3.99.5 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v18_n4_p371_Canga |
Referencias:
- Borda, Peredo, Gimeno, (1983) Prostaglandins, 26, p. 701
- Borda, Sterin-Borda, Gimeno, Lazzari, Gimeno, (1983) Experientia, 39, p. 894
- Canga, Sterin-Borda, Borda, Peredo, Gimeno, (1984) Eur. J. Pharmacol., 110, p. 47
- Downing, Lee, Fripp, (1983) Am. J. Physiol., 245, p. H808
- Farah, Alousi, (1981) Life Sci., 29, p. 975
- Fischer, Yates, (1957) Statistical tables for biological, agricultural and medical research, , 5th ed., Hafner Publishing Co., New York
- Gerrard, Stuart, Rao, Steffes, Mauer, Brown, White, (1980) J. Lab. Clin. Med., 95, p. 950
- Hamberg, (1976) Biochim. Biophys. Acta, 431, p. 651
- Hamby, Zoneraich, Sherman, (1974) J. Am. Med. Ass., 229, p. 1749
- Harrison, Reece, Johnson, (1978) Life Sci., 23, p. 351
- Johnson, Reece, Harrison, (1985) Adv. Prostaglandin Thromboxane Res., 8, p. 1283
- Kannel, Hjortland, Castelli, (1974) Am. J. Cardiol., 34, p. 29
- Kannel, Mc Gee, (1979) J. Am. Med. Ass., 241, p. 2035
- Lapetina, (1982) Trends Pharmacol. Sci., 3, p. 115
- Ledet, Neubauer, Christensen, Lundback, (1979) Diabetología, 16, p. 207
- Moncada, Bunting, Mullane, Thorogood, Vane, Raz, Needleman, (1977) Prostaglandins, 13, p. 611
- Moncada, Vane, (1978) Br. Med. Bull., 34, p. 129
- Moncada, Vane, (1979) Pharmacol. Rev., 30, p. 293
- Nakashima, Tsuru, Shiggei, (1973) J. Pharmacol., 23, p. 307
- Penpargkul, Schaible, Vipintsoi, Scheuer, (1980) Circ. Res., 47, p. 911
- Piper, Samhoun, (1981) Prostaglandins, 24, p. 793
- Pistorius, Axelrod, (1974) J. Biol. Chem., 249, p. 3183
- Sterin-Borda, Borda, del Catillo, Gimeno, Gimeno, (1982) Experientia, 38, p. 835
- Sterin-Borda, Canga, Gimeno, (1981) Experientia, 37, p. 592
- Sterin-Borda, Canga, Pissani, Gimeno, (1980) Prostaglandins, 20, p. 825
- Sterin-Borda, Franchi, Borda, del Castillo, Gimeno, Gimeno, (1984) Eur. J. Pharmacol., 103, p. 211
- Vadlamudi, Vadlamudi, Rodgers, McNeill, (1982) Physiol. Pharmacol., 60, p. 902
- Vane, (1971) Nature New Biol., 231, p. 232
- Van Rossum, (1963) Arch. int. Pharmacodyn, Ther., 143, p. 299
Citas:
---------- APA ----------
Canga, L. & Sterin-Borda, L. (1986) . Increase in atrial contractility induced by PGE2 in diabetic rats. Pharmacological Research Communications, 18(4), 371-384.http://dx.doi.org/10.1016/0031-6989(86)90090-1
---------- CHICAGO ----------
Canga, L., Sterin-Borda, L. "Increase in atrial contractility induced by PGE2 in diabetic rats" . Pharmacological Research Communications 18, no. 4 (1986) : 371-384.http://dx.doi.org/10.1016/0031-6989(86)90090-1
---------- MLA ----------
Canga, L., Sterin-Borda, L. "Increase in atrial contractility induced by PGE2 in diabetic rats" . Pharmacological Research Communications, vol. 18, no. 4, 1986, pp. 371-384.http://dx.doi.org/10.1016/0031-6989(86)90090-1
---------- VANCOUVER ----------
Canga, L., Sterin-Borda, L. Increase in atrial contractility induced by PGE2 in diabetic rats. Pharmacol. Res. Commun. 1986;18(4):371-384.http://dx.doi.org/10.1016/0031-6989(86)90090-1
