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Abstract:

The existence of angiotensin I converting enzyme (CE) activity in isolated sow Fallopian tubes and the "in vitro" influences of exogenous bradykinin (BK) on the spontaneous motility of sow oviducts, were explored, Independently of the stage of the sex cycle, the ampullary region of sow Fallopian tubes presented a higher basal CE activity than the isthmic one. On the other hand a greater CE activity was found in the isthmus at estrus and metestrus than at proestrus. Acetylsalicylic acid and mefenamic acid, two inhibitors of prostaglandin synthesis, reduced the CE activity only in ampullary segments obtained at metestrus. BK (0.06 μg.ml-1) stimulates the spontaneous contractions of isthmic and ampullary tubal segments, triggering tonic responses. The positive inotropism had a longer duration in the isthmus than in the ampulla; presented at estrus a higher magnitude than at proestrus and was enhanced by captopril (50 μg.ml-1). The data suggest that the low CE activity found in the isthmic tubal region could be subserving the positive inotropic action of BK in the isthmus, long lasting in comparison to that evoked in the ampulla. Moreover, at metestrus some tissue eicosanoid might be modulating the foregoing results could be explained assuming the presence of a car{ballot box}y-peptidase different than CE in one region of the oviducts and not in the other, i.e., either one with different sensitivity towards sex hormones and prostaglandin synthesis blockers. © 1986 The Italian Pharmacological Society.

Registro:

Documento: Artículo
Título:Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin
Autor:Ferna ́ndez-Pardal, J.; Chaud, M.; Viggiano, M.; Gimeno, M.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacolo ́gicos, Principios Naturales (CEFAPRIN). Consejo Nacional de Investigaciones Cienti ficas y Te cnicas de la, 1414 Buenos Aires, Argentina
Palabras clave:acetylsalicylic acid; bradykinin; captopril; dipeptidyl carboxypeptidase; mefenamic acid; prostaglandin; prostaglandin e1; prostaglandin e2; prostaglandin f2 alpha; animal cell; cattle; drug efficacy; drug interaction; estrus; female genital system; in vitro study; nonhuman; priority journal; swine; uterine tube; Animals; Bradykinin; Cyclooxygenase Inhibitors; Estrus; Fallopian Tubes; Female; Isometric Contraction; Myocardial Contraction; Peptidyl-Dipeptidase A; Prostaglandin Antagonists; Prostaglandins; Swine
Año:1986
Volumen:18
Número:1
Página de inicio:49
Página de fin:60
DOI: http://dx.doi.org/10.1016/0031-6989(86)90158-X
Título revista:Pharmacological Research Communications
Título revista abreviado:Pharmacol. Res. Commun.
ISSN:00316989
CODEN:PLRCA
CAS:acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; bradykinin, 58-82-2, 5979-11-3; captopril, 62571-86-2; dipeptidyl carboxypeptidase, 9015-82-1; mefenamic acid, 61-68-7; prostaglandin E1, 745-65-3; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; Bradykinin, 58-82-2; Cyclooxygenase Inhibitors; Peptidyl-Dipeptidase A, 3.4.15.1; Prostaglandin Antagonists; Prostaglandins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v18_n1_p49_FernandezPardal

Referencias:

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Citas:

---------- APA ----------
Ferna ́ndez-Pardal, J., Chaud, M., Viggiano, M., Gimeno, M.F. & Gimeno, A.L. (1986) . Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin. Pharmacological Research Communications, 18(1), 49-60.
http://dx.doi.org/10.1016/0031-6989(86)90158-X
---------- CHICAGO ----------
Ferna ́ndez-Pardal, J., Chaud, M., Viggiano, M., Gimeno, M.F., Gimeno, A.L. "Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin" . Pharmacological Research Communications 18, no. 1 (1986) : 49-60.
http://dx.doi.org/10.1016/0031-6989(86)90158-X
---------- MLA ----------
Ferna ́ndez-Pardal, J., Chaud, M., Viggiano, M., Gimeno, M.F., Gimeno, A.L. "Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin" . Pharmacological Research Communications, vol. 18, no. 1, 1986, pp. 49-60.
http://dx.doi.org/10.1016/0031-6989(86)90158-X
---------- VANCOUVER ----------
Ferna ́ndez-Pardal, J., Chaud, M., Viggiano, M., Gimeno, M.F., Gimeno, A.L. Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin. Pharmacol. Res. Commun. 1986;18(1):49-60.
http://dx.doi.org/10.1016/0031-6989(86)90158-X