Abstract:
Dose-response curves for norepinephrine (NE), dopamine (DA) and 2-bromo-α-ergocryptine (BEC) in the isthmic and ampullary regions isolated from proastrous sow oviducts, were drawn. NE, DA and BEC depressed the contractile activity of ampullary segments in dose-dependent fashion. In the isthmic region, NE induced a dose-related stimulation whereas DA and BEC evoked relaxation. Propranolol (10-6M) did not modify significantly the effect of DA on the ampulla, shereas spiperone, chlorpromazine and haloperidol, shifted to the right DA dose-response curves. Haloperidol and spiperone were able to partially antagonize responses to DA of the isthmus. The catecholamine contents of the ampullary (a) and isthmic (i) regions of sow oviducts during proestrus (P), estrus (E) and metestrus (M) proved to be quite different and differently affected by the variations of the sex cycle: NE, DA and spinephrine (EPI) in (i) higher than in (a); NE in (i) and (a) during M higher than during E; NE in (i) lower during E than during P. The probable presence of specific dopamine receptors in sow oviducts as well as their eventual role in modulating tubal motility are discussed in this paper. © 1983 The Italian Pharmacological Society.
Registro:
Documento: |
Artículo
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Título: | Is there a role for dopamine in the regulation of motility of sow oviducts? |
Autor: | Chaud, M.; Pardal, J.F.; Viggiano, M.; Gimeno, M.F.; Gimeno, A.L. |
Filiación: | Centro de Estudios Farmacológicos, Principios Naturales (CEFAPRIN) Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Rep, 1414 Buenos Aires, Argentina
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Palabras clave: | bromocriptine; chlorpromazine; dopamine; haloperidol; noradrenalin; propranolol; spiperone; animal cell; drug efficacy; drug mechanism; estrus; female genital system; muscle; nonhuman; smooth muscle contractility; swine; uterine tube; Animals; Dopamine; Fallopian Tubes; Female; Swine |
Año: | 1983
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Volumen: | 15
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Número: | 10
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Página de inicio: | 923
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Página de fin: | 936
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DOI: |
http://dx.doi.org/10.1016/S0031-6989(83)80022-8 |
Título revista: | Pharmacological Research Communications
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Título revista abreviado: | Pharmacol. Res. Commun.
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ISSN: | 00316989
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CODEN: | PLRCA
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CAS: | bromocriptine, 25614-03-3; chlorpromazine, 50-53-3, 69-09-0; dopamine, 51-61-6, 62-31-7; haloperidol, 52-86-8; noradrenalin, 1407-84-7, 51-41-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; spiperone, 749-02-0; Dopamine, 51-61-6
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v15_n10_p923_Chaud |
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Citas:
---------- APA ----------
Chaud, M., Pardal, J.F., Viggiano, M., Gimeno, M.F. & Gimeno, A.L.
(1983)
. Is there a role for dopamine in the regulation of motility of sow oviducts?. Pharmacological Research Communications, 15(10), 923-936.
http://dx.doi.org/10.1016/S0031-6989(83)80022-8---------- CHICAGO ----------
Chaud, M., Pardal, J.F., Viggiano, M., Gimeno, M.F., Gimeno, A.L.
"Is there a role for dopamine in the regulation of motility of sow oviducts?"
. Pharmacological Research Communications 15, no. 10
(1983) : 923-936.
http://dx.doi.org/10.1016/S0031-6989(83)80022-8---------- MLA ----------
Chaud, M., Pardal, J.F., Viggiano, M., Gimeno, M.F., Gimeno, A.L.
"Is there a role for dopamine in the regulation of motility of sow oviducts?"
. Pharmacological Research Communications, vol. 15, no. 10, 1983, pp. 923-936.
http://dx.doi.org/10.1016/S0031-6989(83)80022-8---------- VANCOUVER ----------
Chaud, M., Pardal, J.F., Viggiano, M., Gimeno, M.F., Gimeno, A.L. Is there a role for dopamine in the regulation of motility of sow oviducts?. Pharmacol. Res. Commun. 1983;15(10):923-936.
http://dx.doi.org/10.1016/S0031-6989(83)80022-8