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Abstract:

Dose-response curves of the positive inotropic effect of PGF2α on isolated rat atria, were examined. It was found a distinct efficacy stimulating the contractile tension of isolated rat atria. The compound elicited a positive inotropism which was augmented in the presence of (-)-propranolol, subthreshold doses of methoxamine, as well as after a treatment with 6-OHDA. On the contrary subthreshold concentrations of norepinephrine or the presence of phentolamine decreased the augmenting inotropic effect of PGF2α. The results suggest that the action of PGF2α is apparently direct and not mediated by the release of the tissue catecholamines. However, adrenergic mechanism appear to be somehow involved in the inotropic influence of PGF2α on the rat atria. © 1981 The Italian Pharmacological Society.

Registro:

Documento: Artículo
Título:Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms
Autor:Canga, L.; Sterin-Borda, L.; Pissani, A.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos, Principios Naturales (CEFAPRIN). Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, 1428 Buenos Aires, Argentina
Palabras clave:methoxamine; noradrenalin; phentolamine; propranolol; prostaglandin F; prostaglandin F2 alpha; adrenergic receptor; methoxamine; noradrenalin; oxidopamine; phentolamine; propranolol; prostaglandin f2 alpha; tyramine; adrenergic system; animal; article; chemical sympathectomy; drug effect; heart atrium; heart contraction; in vitro study; innervation; male; rat; rat strain; stimulation; adrenergic system; animal experiment; autonomic nervous system; drug response; heart; heart atrium; heart muscle contractility; inotropism; Animal; Dinoprost; Heart Atrium; In Vitro; Male; Methoxamine; Myocardial Contraction; Norepinephrine; Phentolamine; Propranolol; Prostaglandins F; Rats; Rats, Inbred Strains; Stimulation, Chemical; Support, Non-U.S. Gov't; Sympathectomy, Chemical; Sympathetic Nervous System
Año:1981
Volumen:13
Número:6
Página de inicio:559
Página de fin:570
DOI: http://dx.doi.org/10.1016/S0031-6989(81)80025-2
Título revista:Pharmacological Research Communications
Título revista abreviado:Pharmacol. Res. Commun.
ISSN:00316989
CODEN:PLRCA
CAS:methoxamine, 390-28-3, 61-16-5; noradrenalin, 1407-84-7, 51-41-2; phentolamine, 50-60-2, 73-05-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; prostaglandin F2 alpha, 551-11-1; oxidopamine, 1199-18-4, 28094-15-7, 636-00-0; tyramine, 51-67-2, 60-19-5; Dinoprost, 551-11-1; Methoxamine, 390-28-3; Norepinephrine, 51-41-2; Phentolamine, 50-60-2; Propranolol, 525-66-6; Prostaglandins F
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n6_p559_Canga

Referencias:

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Citas:

---------- APA ----------
Canga, L., Sterin-Borda, L., Pissani, A. & Gimeno, A.L. (1981) . Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms. Pharmacological Research Communications, 13(6), 559-570.
http://dx.doi.org/10.1016/S0031-6989(81)80025-2
---------- CHICAGO ----------
Canga, L., Sterin-Borda, L., Pissani, A., Gimeno, A.L. "Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms" . Pharmacological Research Communications 13, no. 6 (1981) : 559-570.
http://dx.doi.org/10.1016/S0031-6989(81)80025-2
---------- MLA ----------
Canga, L., Sterin-Borda, L., Pissani, A., Gimeno, A.L. "Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms" . Pharmacological Research Communications, vol. 13, no. 6, 1981, pp. 559-570.
http://dx.doi.org/10.1016/S0031-6989(81)80025-2
---------- VANCOUVER ----------
Canga, L., Sterin-Borda, L., Pissani, A., Gimeno, A.L. Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms. Pharmacol. Res. Commun. 1981;13(6):559-570.
http://dx.doi.org/10.1016/S0031-6989(81)80025-2