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Abstract:

Potency and efficacy of isoproterenol were different in the epididymal and in the prostatic portion of the rat vas deferens as well as between preparations obtained from normal or castrated animals. The epididymal portion exhibited alpha excitatory as well as beta inhibitory effects following isoproterenol; whereas the prostatic part reacted with an excitatory response to isoproterenol only in the castrated group. Phentolamine blocked the excitatory action and propranolol the inhibitory one. The variable differences to the alpha excitatory and beta inhibitory effects of isoproterenol between preparations from normal and castrated rats, could be due to a apecial postjunctional supersensitivity related to the lack of testosterone. © 1981 The Italian Pharmacological Society.

Registro:

Documento: Artículo
Título:Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens
Autor:Borde, E.S.; Agostini, M.d.C.; Gimeno, M.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientifices y Tecnicas de la Republica Argentina (CONICET). V. d, 1428 Buenos Aires, Argentina
Palabras clave:adrenergic receptor; alpha adrenergic receptor; barium chloride; beta adrenergic receptor; isoprenaline; phentolamine; phentolamine mesylate; propranolol; animal experiment; autonomic nervous system; castration; in vitro study; male genital system; rat; smooth muscle contractility; vas deferens; Animal; Castration; Dose-Response Relationship, Drug; Epididymis; In Vitro; Isoproterenol; Male; Muscle Contraction; Prostate; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Support, Non-U.S. Gov't; Vas Deferens
Año:1981
Volumen:13
Número:5
Página de inicio:487
Página de fin:499
DOI: http://dx.doi.org/10.1016/S0031-6989(81)80075-6
Título revista:Pharmacological Research Communications
Título revista abreviado:Pharmacol. Res. Commun.
ISSN:00316989
CODEN:PLRCA
CAS:barium chloride, 10361-37-2; isoprenaline, 299-95-6, 51-30-9, 6700-39-6, 7683-59-2; phentolamine mesylate, 65-28-1; phentolamine, 50-60-2, 73-05-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; Isoproterenol, 7683-59-2; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n5_p487_Borde

Referencias:

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Citas:

---------- APA ----------
Borde, E.S., Agostini, M.d.C., Gimeno, M.F. & Gimeno, A.L. (1981) . Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens. Pharmacological Research Communications, 13(5), 487-499.
http://dx.doi.org/10.1016/S0031-6989(81)80075-6
---------- CHICAGO ----------
Borde, E.S., Agostini, M.d.C., Gimeno, M.F., Gimeno, A.L. "Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens" . Pharmacological Research Communications 13, no. 5 (1981) : 487-499.
http://dx.doi.org/10.1016/S0031-6989(81)80075-6
---------- MLA ----------
Borde, E.S., Agostini, M.d.C., Gimeno, M.F., Gimeno, A.L. "Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens" . Pharmacological Research Communications, vol. 13, no. 5, 1981, pp. 487-499.
http://dx.doi.org/10.1016/S0031-6989(81)80075-6
---------- VANCOUVER ----------
Borde, E.S., Agostini, M.d.C., Gimeno, M.F., Gimeno, A.L. Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens. Pharmacol. Res. Commun. 1981;13(5):487-499.
http://dx.doi.org/10.1016/S0031-6989(81)80075-6