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Abstract:

The contractile reactivity to sympathetic agonists of two different regions of the rat uterus: mesometrial (M) and antimesometrial or lines uteri (LU), was studied. The inhibitory effects of the adrenergic agonists on the spontaneous as well as on the oxytocin-triggered activity were greater in the M region than in the LU. Beta-adrenoceptor blocking agents abolished the different sensitivity towards the adrenergic agonists between both zones. The results suggest that in the M region there is a higher population of beta adrenoceptors or an augmented affinity of the agonist for them than in the LU. © 1981 The Italian Pharmacological Society.

Registro:

Documento: Artículo
Título:A different contractile response to catecholamines of two regions (mesometrial and antimesometrial) of isolated rat uterine horns
Autor:Sterin-Speziale, N.; Gimeno, M.F.; Borda, E.; Chaud, M.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), the Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET)., 1428 Buenos Aires, Argentina
Palabras clave:isoprenaline; noradrenalin; oxytocin; phentolamine; phentolamine mesylate; phenylephrine; sotalol; animal experiment; female genital system; in vitro study; muscle; rat; smooth muscle contraction; uterus contractility; uterus contraction; uterus horn; Animals; Catecholamines; Dose-Response Relationship, Drug; Female; Isoproterenol; Norepinephrine; Oxytocin; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Sympatholytics; Uterine Contraction
Año:1981
Volumen:13
Número:4
Página de inicio:401
Página de fin:411
DOI: http://dx.doi.org/10.1016/S0031-6989(81)80008-2
Título revista:Pharmacological Research Communications
Título revista abreviado:Pharmacol. Res. Commun.
ISSN:00316989
CODEN:PLRCA
CAS:isoprenaline, 299-95-6, 51-30-9, 6700-39-6, 7683-59-2; noradrenalin, 1407-84-7, 51-41-2; oxytocin, 50-56-6, 54577-94-5; phentolamine, 50-60-2, 73-05-2; phentolamine mesylate, 65-28-1; phenylephrine, 532-38-7, 59-42-7, 61-76-7; sotalol, 3930-20-9, 80456-07-1, 959-24-0; Catecholamines; Isoproterenol, 7683-59-2; Norepinephrine, 51-41-2; Oxytocin, 50-56-6; Phenylephrine, 59-42-7; Receptors, Adrenergic; Sympatholytics
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n4_p401_SterinSpeziale

Referencias:

  • Borda, Sauvage, Sterin-Borda, Gimeno, Gimeno, (1979) Europ.J.Pharmac., 56, pp. 61-67
  • Borda, Sterin-Borda, Sterin-Speziale, Gimeno, Gimeno, (1978) Acta physiol.latinoam., 28, pp. 223-233
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  • Gimeno, Borda, Sterin-Borda, Vidal, Gimeno, (1976) Obstet.Gynecol., 47, pp. 218-222
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  • González, Torres, Gimeno, Gimeno, Substrate Requirements in vitro for the Spontaneous Motility of Uterine Strips from Ovariectomized or Natural Estrus Rats: Relationships with tissue levels of glycogen and triglycerides (1976) Archives Of Physiology And Biochemistry, 84, pp. 213-217
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Citas:

---------- APA ----------
Sterin-Speziale, N., Gimeno, M.F., Borda, E., Chaud, M. & Gimeno, A.L. (1981) . A different contractile response to catecholamines of two regions (mesometrial and antimesometrial) of isolated rat uterine horns. Pharmacological Research Communications, 13(4), 401-411.
http://dx.doi.org/10.1016/S0031-6989(81)80008-2
---------- CHICAGO ----------
Sterin-Speziale, N., Gimeno, M.F., Borda, E., Chaud, M., Gimeno, A.L. "A different contractile response to catecholamines of two regions (mesometrial and antimesometrial) of isolated rat uterine horns" . Pharmacological Research Communications 13, no. 4 (1981) : 401-411.
http://dx.doi.org/10.1016/S0031-6989(81)80008-2
---------- MLA ----------
Sterin-Speziale, N., Gimeno, M.F., Borda, E., Chaud, M., Gimeno, A.L. "A different contractile response to catecholamines of two regions (mesometrial and antimesometrial) of isolated rat uterine horns" . Pharmacological Research Communications, vol. 13, no. 4, 1981, pp. 401-411.
http://dx.doi.org/10.1016/S0031-6989(81)80008-2
---------- VANCOUVER ----------
Sterin-Speziale, N., Gimeno, M.F., Borda, E., Chaud, M., Gimeno, A.L. A different contractile response to catecholamines of two regions (mesometrial and antimesometrial) of isolated rat uterine horns. Pharmacol. Res. Commun. 1981;13(4):401-411.
http://dx.doi.org/10.1016/S0031-6989(81)80008-2